Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Gniewomir, Latacz"'
Autor:
Magdalena Kurnik-Łucka, Gniewomir Latacz, Adam Bucki, Mario Rivera-Meza, Nadia Khan, Jahnobi Konwar, Kamil Skowron, Marcin Kołaczkowski, Krzysztof Gil
Publikováno v:
ACS Omega, Vol 8, Iss 41, Pp 38566-38576 (2023)
Externí odkaz:
https://doaj.org/article/6c0c5837447a426eb079d2d04b52c201
Autor:
Karolina Witek, Aneta Kaczor, Ewa Żesławska, Sabina Podlewska, Małgorzata Anna Marć, Kinga Czarnota-Łydka, Wojciech Nitek, Gniewomir Latacz, Waldemar Tejchman, Markus Bischoff, Claus Jacob, Jadwiga Handzlik
Publikováno v:
Antibiotics, Vol 12, Iss 11, p 1618 (2023)
In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted. The purpose
Externí odkaz:
https://doaj.org/article/b86e873063524db1aa3c92b6214f256f
Autor:
Monika Kubacka, Barbara Nowak, Monika Zadrożna, Małgorzata Szafarz, Gniewomir Latacz, Henryk Marona, Jacek Sapa, Szczepan Mogilski, Marek Bednarski, Magdalena Kotańska
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1130 (2023)
Excessive fructose consumption may lead to metabolic syndrome, metabolic dysfunction-associated fatty liver disease (MAFLD) and hypertension. α1-adrenoceptors antagonists are antihypertensive agents that exert mild beneficial effects on the metaboli
Externí odkaz:
https://doaj.org/article/d003b1d9fb2148d98d4eab2769f57ff8
Autor:
Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Edyta Pindelska, Gniewomir Latacz, Jolanta Jaśkowska
Publikováno v:
Ultrasonics Sonochemistry, Vol 90, Iss , Pp 106165- (2022)
The chemotype of arylsulfonamide derivatives of cyclic arylguanidines is a source of molecules with valuable biological activities, including antimicrobial and antitumor properties. The methods of the synthesis presented in the literature are charact
Externí odkaz:
https://doaj.org/article/786644e790e6428fbe68881762e7f2a6
Autor:
Agnieszka Olejarz-Maciej, Szczepan Mogilski, Tadeusz Karcz, Tobias Werner, Katarzyna Kamińska, Jarosław Kupczyk, Ewelina Honkisz-Orzechowska, Gniewomir Latacz, Holger Stark, Katarzyna Kieć-Kononowicz, Dorota Łażewska
Publikováno v:
Molecules, Vol 28, Iss 10, p 4199 (2023)
Pain is a very unpleasant experience that makes life extremely uncomfortable. The histamine H4 receptor (H4R) is a promising target for the treatment of inflammatory and immune diseases, as well as pain. H4R ligands have demonstrated analgesic effect
Externí odkaz:
https://doaj.org/article/a1345330633546a088998c7589f4d043
Autor:
Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 675 (2023)
This study examines the properties of novel guanidines, designed and synthesized as histamine H3R antagonists/inverse agonists with additional pharmacological targets. We evaluated their potential against two targets viz., inhibition of MDA-MB-231, a
Externí odkaz:
https://doaj.org/article/b9fb5d11a66f4497888c7bc071bb662d
Autor:
Dorota Łażewska, Małgorzata Więcek, Grzegorz Satała, Paulina Chałupnik, Ewa Żesławska, Ewelina Honkisz-Orzechowska, Monika Tarasek, Gniewomir Latacz, Wojciech Nitek, Ewa Szymańska, Jadwiga Handzlik
Publikováno v:
Molecules, Vol 28, Iss 3, p 1108 (2023)
Since the number of people with Alzheimer’s disease (AD) continues to rise, new and effective drugs are urgently needed to not only slow down the progression of the disease, but to stop or even prevent its development. Serotonin 5-HT6 receptor (5-H
Externí odkaz:
https://doaj.org/article/2818bbb54cea49789517aaf59945ee75
Autor:
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Publikováno v:
Molecules, Vol 28, Iss 1, p 238 (2022)
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease. In this study, a nove
Externí odkaz:
https://doaj.org/article/2481fe283dea45f89bc7efb49683033f
Autor:
Przemysław Zaręba, Anna Partyka, Gniewomir Latacz, Grzegorz Satała, Paweł Zajdel, Jolanta Jaśkowska
Publikováno v:
Molecules, Vol 27, Iss 21, p 7270 (2022)
Serotonin 5-HT1A and 5-HT7 receptors play an important role in the pathogenesis and pharmacotherapy of depression. Previously identified N-hexyl trazodone derivatives, 2-(6-(4-(3-chlorophenyl)piperazin-1-yl)hexyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-
Externí odkaz:
https://doaj.org/article/abb2ec901f6745188f2c96f2b8bb5db7
Autor:
Marcin Jakubiec, Michał Abram, Mirosław Zagaja, Marta Andres-Mach, Aleksandra Szewczyk, Gniewomir Latacz, Bartłomiej Szulczyk, Katarzyna Socała, Dorota Nieoczym, Piotr Wlaź, Cameron S. Metcalf, Karen Wilcox, Rafał M. Kamiński, Krzysztof Kamiński
Publikováno v:
Cells, Vol 11, Iss 12, p 1862 (2022)
In the present study, a focused combinatorial chemistry approach was applied to merge structural fragments of well-known TRPV1 antagonists with a potent anticonvulsant lead compound, KA-104, that was previously discovered by our group. Consequently,
Externí odkaz:
https://doaj.org/article/9d34a801f4aa4feab4747cefcea04a31