De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function.

Autor: Wu R; Center for Childhood Cancer and Blood Diseases, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA., Chen X; Center for Childhood Cancer and Blood Diseases, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA., Kang S; Center for Childhood Cancer and Blood Diseases, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA., Wang T; Center for Childhood Cancer and Blood Diseases, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA., Gnanaprakasam JR; Center for Childhood Cancer and Blood Diseases, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA., Yao Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Liu L; Center for Childhood Cancer and Blood Diseases, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA., Fan G; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Burns MR; Aminex Therapeutics Inc., Epsom, NH 03234, USA., Wang R; Center for Childhood Cancer and Blood Diseases, Hematology/Oncology and BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA. ruoning.wang@nationwidechildrens.org.

Publikováno v: Science advances [Sci Adv] 2020 Dec 16; Vol. 6 (51). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

Autor: Lian G; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States.; Medical Research Center, University of South China, Hengyang, Hunan Province, China., Gnanaprakasam JR; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States., Wang T; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States., Wu R; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States., Chen X; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States., Liu L; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States., Shen Y; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States., Yang M; Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States., Yang J; Department of Surgery, St. Jude Children's Research Hospital, Memphis, United States., Chen Y; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, United States., Vasiliou V; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, United States., Cassel TA; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, United States.; Markey Cancer Center, University of Kentucky, Lexington, United States.; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, United States., Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, United States., Liu Y; Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, United States., Fan TW; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, United States.; Markey Cancer Center, University of Kentucky, Lexington, United States.; Center for Environmental and Systems Biochemistry, University of Kentucky, Lexington, United States., Wang R; Center for Childhood Cancer and Blood Diseases, Hematology, Oncology and BM, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, United States.

Publikováno v: ELife [Elife] 2018 Sep 10; Vol. 7. Date of Electronic Publication: 2018 Sep 10.

Bone marrow plasma metabonomics of idiopathic acquired aplastic anemia patients using 1H nuclear magnetic resonance spectroscopy.

Autor: Srivastava, Jyotika¹ (AUTHOR), Trivedi, Rimjhim^2,3 (AUTHOR), Saxena, Pragati¹ (AUTHOR), Yadav, Sanjeev⁴ (AUTHOR), Gupta, Ruchi⁴ (AUTHOR), Nityanand, Soniya⁴ (AUTHOR), Kumar, Dinesh^2,3 (AUTHOR) dineshcbmr@gmail.com, Chaturvedi, Chandra P.¹ (AUTHOR) chaturvedicp75@rediffmail.com

Publikováno v: Metabolomics. Dec2023, Vol. 19 Issue 12, p1-15. 15p.

Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity.

Autor: Zheng, Yue^1,2 (AUTHOR), Yao, Yiran^1,2 (AUTHOR), Ge, Tongxin^1,2 (AUTHOR), Ge, Shengfang^1,2 (AUTHOR), Jia, Renbing^1,2 (AUTHOR) renbingjia@sjtu.edu.cn, Song, Xin^1,2 (AUTHOR) drsongxin_eye@163.com, Zhuang, Ai^1,2 (AUTHOR) aizh9h@163.com

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 11/3/2023, Vol. 42 Issue 1, p1-23. 23p.

A positive correlation between serum lactate dehydrogenase level and in-hospital mortality in ICU sepsis patients: evidence from two large databases.

Autor: Yu, Huijie, Yang, Qilin, Qian, Yuanwei, Luo, Siyan, Kong, Tianyu, Yang, Guangqian, Chen, Weiyan, Xie, Fuhua, Chen, Jieru, Xiong, Xuming, Wen, Deliang, Zhang, Zhenhui

Publikováno v: European Journal of Medical Research; 11/1/2024, Vol. 29 Issue 1, p1-12, 12p