Asparagine restriction enhances CD8 ⁺ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response.

Autor: Gnanaprakasam JNR; Center for Childhood Cancer, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University, Columbus, OH, USA., Kushwaha B; Center for Childhood Cancer, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University, Columbus, OH, USA., Liu L; Center for Childhood Cancer, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University, Columbus, OH, USA., Chen X; Center for Childhood Cancer, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University, Columbus, OH, USA., Kang S; Center for Childhood Cancer, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University, Columbus, OH, USA., Wang T; Center for Childhood Cancer, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University, Columbus, OH, USA., Cassel TA; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Adams CM; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Higashi RM; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Scott DA; Cancer Metabolism Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Xin G; Department of Microbial Infection and Immunity, Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA., Li Z; Department of Microbial Infection and Immunity, Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA., Yang J; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pathology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA., Lane AN; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Fan TW; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Zhang J; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Wang R; Center for Childhood Cancer, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics at The Ohio State University, Columbus, OH, USA. ruoning.wang@nationwidechildrens.org.

Publikováno v: Nature metabolism [Nat Metab] 2023 Aug; Vol. 5 (8), pp. 1423-1439. Date of Electronic Publication: 2023 Aug 07.

Optimizing CD8⁺ T cell-based immunotherapy via metabolic interventions: a comprehensive review of intrinsic and extrinsic modulators.

Autor: Zhou, Zihao¹ (AUTHOR), Zheng, Jiarong² (AUTHOR), Lu, Ye¹ (AUTHOR), Mai, Zizhao¹ (AUTHOR), Lin, Yunfan¹ (AUTHOR), Lin, Pei¹ (AUTHOR), Zheng, Yucheng¹ (AUTHOR), Chen, Xu¹ (AUTHOR), Xu, Rongwei¹ (AUTHOR), Zhao, Xinyuan¹ (AUTHOR) zhaoxinyuan1989@smu.edu.cn, Cui, Li^1,3 (AUTHOR) licui@smu.edu.cn

Publikováno v: Experimental Hematology & Oncology. 10/22/2024, Vol. 13 Issue 1, p1-21. 21p.

Inosine is an alternative carbon source for CD8 ⁺ -T-cell function under glucose restriction.

Autor: Wang T; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Gnanaprakasam JNR; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Chen X; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Kang S; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Xu X; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Sun H; The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Liu L; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Rodgers H; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Miller E; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Cassel TA; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Sun Q; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Vicente-Muñoz S; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Warmoes MO; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Lin P; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Piedra-Quintero ZL; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, Ohio State University, Columbus, OH, USA., Guerau-de-Arellano M; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, Ohio State University, Columbus, OH, USA., Cassady KA; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA., Zheng SG; Division of Rheumatology and Immunology, Department of Internal Medicine at Ohio State University of Medicine and Wexner Medical Center, Columbus, OH, USA., Yang J; Department of Surgery, St Jude Children's Research Hospital, Memphis, TN, USA., Lane AN; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Song X; The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA. shautong.song@icellkealex.com.; Icell Kealex Therapeutics, Houston, TX, USA. shautong.song@icellkealex.com., Fan TW; Center for Environmental and Systems Biochemistry, Department of Toxicology and Cancer Biology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA. twmfan@gmail.com., Wang R; Center for Childhood Cancer & Blood Diseases, Hematology/Oncology & BMT, Abigail Wexner Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA. ruoning.wang@nationwidechildrens.org.

Publikováno v: Nature metabolism [Nat Metab] 2020 Jul; Vol. 2 (7), pp. 635-647. Date of Electronic Publication: 2020 Jun 15.

The significant role of amino acid metabolic reprogramming in cancer.

Autor: Liu, Xiaohong^1,2,3 (AUTHOR), Ren, Bo^1,2,3 (AUTHOR), Ren, Jie^1,2,3 (AUTHOR), Gu, Minzhi^1,2,3 (AUTHOR), You, Lei^1,2,3 (AUTHOR) florayo@163.com, Zhao, Yupei^1,2,3 (AUTHOR) zhao8028@263.net

Publikováno v: Cell Communication & Signaling. 7/29/2024, Vol. 22 Issue 1, p1-26. 26p.

Potential mechanisms and targeting strategies of the gut microbiota in antitumor immunity and immunotherapy.

Autor: Yin, Qian¹ (AUTHOR), Ni, Jiao‐jiao² (AUTHOR), Ying, Jie‐er² (AUTHOR) jieerying@aliyun.com

Publikováno v: Immunity, Inflammation & Disease. Jul2024, Vol. 12 Issue 7, p1-13. 13p.