Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gnana, Ravi"'
Publikováno v:
Drug development research. 54(2)
Novel analogs of 1-(N,O-bis[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine (KN-62,1) were synthesized and found to be potent antagonists in a functional assay, inhibition of ATP-induced K+ efflux in HEK293 cells expressing recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64bdabd768da3857274c0c0bf65bee55
https://pubmed.ncbi.nlm.nih.gov/27019545
https://pubmed.ncbi.nlm.nih.gov/27019545
Autor:
Wangzhong Chen, Kenneth A. Jacobson, Hak Sung Kim, Kyeong Lee, Aishe Chen, Soo-Kyung Kim, Zhan-Guo Gao, Bruce T. Liang, Gnana Ravi, Dov Barak, Seong Gon Kim
Publikováno v:
Drug Dev Res
Modification of the ribose moiety of nucleotides and nucleosides has provided new insights into structural and conformational requirements for ligands at P2Y nucleotide receptors and at adenosine receptors (ARs). Methanocarba derivatives (containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9372b350d350708a7f60a45b0ef9de73
https://doi.org/10.1002/ddr.10168
https://doi.org/10.1002/ddr.10168
Autor:
James Lacy, G L Waldo, José L. Boyer, Gnana Ravi, Xiao-duo Ji, T. Kendall Harden, James Corbitt, Hak-Sung Kim, Kenneth A. Jacobson
Publikováno v:
Molecular Pharmacology. 62:1249-1257
2-Chloro- N 6 -methyl-( N )-methanocarba-2′-deoxyadenosine-3′,5′- bisphosphate (MRS2279) was developed previously as a selective high-affinity, non-nucleotide P2Y 1 receptor (P2Y1-R) antagonist ( J Med Chem 43: 829–842, 2002; Br J Pharmacol 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30480cc69a12c8ce4422802584bed28f
https://doi.org/10.1124/mol.62.5.1249
https://doi.org/10.1124/mol.62.5.1249
Publikováno v:
British Journal of Pharmacology. 135:2004-2010
1. We reported previously that bisphosphate derivatives of adenosine are antagonists of the P2Y(1) receptor and that modification of the ribose in these analogues is tolerated in the P2Y(1) receptor binding pharmacophore. 2. Here we delineate the pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e940b3c39f1496c7bd2454179f8c6800
https://doi.org/10.1038/sj.bjp.0704673
https://doi.org/10.1038/sj.bjp.0704673
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1333-1337
Novel methanocarba adenosine analogues, having the pseudo-ribose northern (N) conformation preferred at adenosine receptors (ARs), were synthesized and tested in binding assays. The 5'-uronamide modification preserved [N6-(3-iodobenzyl)] or enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4b0fc05b084b6672a71ced287c05f6
https://doi.org/10.1016/s0960-894x(01)00213-x
https://doi.org/10.1016/s0960-894x(01)00213-x
Autor:
Hak Sung Kim, T. Kendall Harden, Stefano Moro, Yong-Chul Kim, José L. Boyer, Kenneth A. Jacobson, R. Gnana Ravi, Carsten Hoffmann
Publikováno v:
Il Farmaco. 56:71-75
The P2Y1 receptor responds to adenine nucleotides and is present in platelets, heart, smooth muscles prostate, ovary, and brain. A selective antagonist may be useful as an antithrombotic agent. We have analyzed the binding site of this G protein-coup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bc27a3f472065e2ec8f7eb3041ec8c
https://doi.org/10.1016/s0014-827x(01)01023-0
https://doi.org/10.1016/s0014-827x(01)01023-0
Publikováno v:
Drug Development Research. 54:75-87
Novel analogs of 1-(N,O-bis[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine (KN-62,1) were synthesized and found to be potent antagonists in a functional assay, inhibition of ATP-induced K+ efflux in HEK293 cells expressing recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfa8ef0a406aadbd3c6cf1219b11e532
https://doi.org/10.1002/ddr.1207
https://doi.org/10.1002/ddr.1207
Publikováno v:
Tetrahedron: Asymmetry. 10:3103-3106
A new enantioselective approach to α-alkyl-α-hydroxy-γ-butyrolactones employing (1R,2S)-ephedrine-derived chiral allyl morpholinones as starting materials is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84e667dffa547fda64385d3fca037c82
https://doi.org/10.1016/s0957-4166(99)00343-2
https://doi.org/10.1016/s0957-4166(99)00343-2
Asymmetric reactions of α-ketoacid-derived hemiacetals: Stereoselective synthesis of α-hydroxy acids
Autor:
Sunil V. Pansare, R. Gnana Ravi
Publikováno v:
Tetrahedron. 54:14549-14564
N-Acylation of prolinol with α-ketoacid chlorides results in concomitant hemiacetalization of the α-keto amide by the prolinol hydroxyl group. (R) or (S) α-hydroxy acids are obtained with good enantiomeric excess by stereodivergent reduction of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438dba884f4ec4fd001f4a3985c8d9ff
https://doi.org/10.1016/s0040-4020(98)00914-4
https://doi.org/10.1016/s0040-4020(98)00914-4
Publikováno v:
The Journal of Organic Chemistry. 63:4120-4124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe019f85f9630bb824007f8712e851fa
https://doi.org/10.1021/jo9722820
https://doi.org/10.1021/jo9722820