Výsledky vyhledávání - "Gm, Anlezark"

Akademický článek

Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954.

Autor: Anlezark GM; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Vaughan T; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Fashola-Stone E; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Paul Michael N; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Murdoch H; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Sims MA; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Stubbs S; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Wigley S; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1., Minton NP; Centre for Applied Microbiology and Research (CAMR), Porton Down, Salisbury, Wiltshire SP4 0JG, UK1.

Publikováno v: Microbiology (Reading, England) [Microbiology (Reading)] 2002 Jan; Vol. 148 (Pt 1), pp. 297-306.

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Akademický článek

Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.

Autor: Green NK; Department of Surgery, University of Birmingham, UK., Youngs DJ, Neoptolemos JP, Friedlos F, Knox RJ, Springer CJ, Anlezark GM, Michael NP, Melton RG, Ford MJ, Young LS, Kerr DJ, Searle PF

Publikováno v: Cancer gene therapy [Cancer Gene Ther] 1997 Jul-Aug; Vol. 4 (4), pp. 229-38.

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Akademický článek

Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

Autor: Anlezark GM; Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wilts, U.K., Melton RG, Sherwood RF, Wilson WR, Denny WA, Palmer BD, Knox RJ, Friedlos F, Williams A

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 1995 Aug 25; Vol. 50 (5), pp. 609-18.

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Akademický článek

Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT).

Autor: Knox RJ; CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, U.K., Friedlos F, Jarman M, Davies LC, Goddard P, Anlezark GM, Melton RG, Sherwood RF

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 1995 May 26; Vol. 49 (11), pp. 1641-7.

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Akademický článek

Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12.

Autor: Michael NP; Department of Molecular Microbiology, Centre for Applied Microbiology and Research, Salisbury, Wiltshire, UK., Brehm JK, Anlezark GM, Minton NP

Publikováno v: FEMS microbiology letters [FEMS Microbiol Lett] 1994 Dec 01; Vol. 124 (2), pp. 195-202.

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Akademický článek

Crystallization and preliminary crystallographic data for an FMN-dependent nitroreductase from Escherichia coli B.

Autor: Skelly JV; CRC Biomolecular Structure Unit, Institute of Cancer Research Sutton, Surrey, U.K., Collins PJ, Knox RJ, Anlezark GM, Melton RG

Publikováno v: Journal of molecular biology [J Mol Biol] 1994 May 20; Vol. 238 (5), pp. 852-3.

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Akademický článek

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

Autor: Anlezark GM; Division of Biotechnology, PHLS Centre for Applied Microbiology and Research, Salisbury, Wiltshire, U.K., Melton RG, Sherwood RF, Coles B, Friedlos F, Knox RJ

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 1992 Dec 15; Vol. 44 (12), pp. 2289-95.

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Akademický článek

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.

Autor: Knox RJ; Molecular Pharmacology Unit, Institute of Cancer Research, Sutton, Surrey, U.K., Friedlos F, Sherwood RF, Melton RG, Anlezark GM

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 1992 Dec 15; Vol. 44 (12), pp. 2297-301.

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Akademický článek

Acute dystonia as an idiosyncratic response to neuroleptics in baboons.

Autor: Meldrum BS, Anlezark GM, Marsden CD

Publikováno v: Brain : a journal of neurology [Brain] 1977 Jun; Vol. 100 (2), pp. 313-26.

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