Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Glynn P. Wheeler"'
Autor:
Linda Simpson-Herren, Glynn P. Wheeler
Publikováno v:
Cancer Research. 66:12035-12036
Howard Earle Skipper died at his residence in Mountain Brook, Alabama on January 2, 2006 at age 90. He was born on November 21, 1915 at Avon Park, Florida to Chesley Allen Skipper and Estelle Wiggins Skipper. He grew up in Sebring, Florida, and in hi
Synthesis of potential anticancer agents. Pyrido[4,3-b][1,4]oxazines and pyrido[4,3-b][1,4]thiazines
Publikováno v:
Journal of Medicinal Chemistry. 26:1614-1619
Hydrolysis of the chloro group of ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (3) with formic acid gave the corresponding 4-hydroxypyridine 4. Catalytic hydrogenation of the nitro group of 4 gave the 5-amino-4-hydroxypyridine 5, which was r
Autor:
Glynn P. Wheeler, Robert D. Elliott, Conrad L. Kussner, Jerry D. Rose, Robert N. Comber, John A. Montgomery, Carroll Temple
Publikováno v:
Journal of Medicinal Chemistry. 25:1045-1050
Reaction of alpha-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-[(2-oxo-2-phenylethyl)amino]pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give
Autor:
Glynn P. Wheeler, Carroll Temple, Robert N. Comber, John A. Montgomery, Jerry D. Rose, Robert D. Elliott
Publikováno v:
Journal of Medicinal Chemistry. 26:91-95
Certain derivatives containing the 1,2-dihydropyrido[3,4-b]pyrazine (1-deaza-7,8-dihydropteridine) ring system are active against experimental neoplasms in mice. The mechanism of action of these agents has been attributed to the accumulation of cells
Autor:
Glynn P. Wheeler, Margaret G. Grammer
Publikováno v:
Biochemical Pharmacology. 3:316-327
Purines, pyrimidines, ribonucleosides, ribonucleotides, carboxylic acids, and amino acids were tested for activity in preventing the growth-inhibition of Escherichia coli by urethan, formamide and N-methylformamide. 2: 6-Diaminopurine and phenylalani
Autor:
Bonnie J. Bowdon, Glynn P. Wheeler
Publikováno v:
Journal of Biological Chemistry. 241:1114-1121
Experimental evidence indicates that an analogue of nicotinamide adenine dinucleotide in which the adenine moiety is replaced by 2,6-diaminopurine is formed when cultured mammalian cells are grown in the presence of 2,6-diaminopurine. It is also like
Autor:
Glynn P. Wheeler, Howard E. Skipper
Publikováno v:
Archives of Biochemistry and Biophysics. 72:465-475
Experimental evidence is presented which strongly suggests that C 14 from injected nitrogen mustard-C 14 H 3 is fixed in the nucleic acid fractions of animal tissues chiefly as a result of the combination of the nitrogen mustard with nucleic acid moi
Publikováno v:
Biochemical Pharmacology. 15:881-889
4-Hydroxypyrazolo(3,4-d)pyrimidine (HPP) injected i.p. caused an inhibition of xanthine oxidase activity in the livers and kidneys (but not the spleens) of rats, as measured by catabolism of hypoxanthine-8- 14 C ( in vivo and in vitro ), inosine (8-
Publikováno v:
JNCI: Journal of the National Cancer Institute. 36:709-715
Publikováno v:
Experimental Biology and Medicine. 126:903-906
SummaryThe cell cycles of Leukemia L1210 cells proliferating in mice after serial transplantation, proliferating in mice following inoculation of cultured cells, and proliferating in vitro in spinner cultures have been examined by the method of waves