Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Glynis Nicholls"'
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Modeling Gadoxetate Liver Uptake and Efflux Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging Enables Preclinical Quantification of Transporter Drug-Drug Interactions
Autor: Penny L. Hubbard Cristinacce, Neil Woodhouse, Josephine H. Naish, Glynis Nicholls, Jeffrey Penny, Leonidas Georgiou, François-Xavier Blé
Publikováno v: Investigative Radiology. 53:563-570
The aim of this study was to model the in vivo transporter-mediated uptake and efflux of the hepatobiliary contrast agent gadoxetate in the liver. The efficacy of the proposed technique was assessed for its ability to provide quantitative insights in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3568eea58b89100b0a83ac1544837e2
https://doi.org/10.1097/rli.0000000000000480
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2
Quantitative Assessment of Liver Function Using Gadoxetate-Enhanced Magnetic Resonance Imaging:Monitoring Transporter-Mediated Processes in Healthy Volunteers
Autor: Penny L. Hubbard Cristinacce, Leonidas Georgiou, Josephine H. Naish, Neil Woodhouse, Jeffrey Penny, Glynis Nicholls, François-Xavier Blé
Publikováno v: Georgiou, L, Penny, J, Nicholls, G, Woodhouse, N, Blé, F-X, Hubbard Cristinacce, P L & Naish, J H 2017, ' Quantitative Assessment of Liver Function Using Gadoxetate-Enhanced Magnetic Resonance Imaging : Monitoring Transporter-Mediated Processes in Healthy Volunteers ' Invest Radiol, vol 52, no. 2, pp. 111-119 . DOI: 10.1097/RLI.0000000000000316
Georgiou, L, Penny, J, Nicholls, G, Woodhouse, N, Blé, F-X, Hubbard Cristinacce, P L & Naish, J H 2017, ' Quantitative assessment of liver function using Gadoxetate-Enhanced Magnetic Resonance Imaging : Monitoring Transporter-Mediated processes in healthy volunteers ', Investigative Radiology, vol. 52, no. 2, pp. 111-119 . https://doi.org/10.1097/RLI.0000000000000316
Investigative Radiology
OBJECTIVE: The objective of this study was to use noninvasive dynamic contrast-enhanced magnetic resonance imaging (MRI) techniques to study, in vivo, the distribution and elimination of the hepatobiliary contrast agent gadoxetate in the human body a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80768a12cb384a361a6fc9d228256b8a
https://www.research.manchester.ac.uk/portal/en/publications/quantitative-assessment-of-liver-function-using-gadoxetateenhanced-magnetic-resonance-imaging(13037927-da7d-4d6e-a2a8-a656aba817f7).html
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3
Elektronická kniha
Drug Transporters : Volume 2: Recent Advances and Emerging Technologies
Autor: Glynis Nicholls, Kuresh Youdim
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences
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4
Elektronická kniha
Drug Transporters : Volume 1: Role and Importance in ADME and Drug Development
Autor: Glynis Nicholls, Kuresh Youdim
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sci
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5
Chapter 6. The Role of In vivo Imaging in the Study of Transporter Interactions in Animals and Humans
Autor: Heather Flynn, Neil Woodhouse, Glynis Nicholls
Non-invasive imaging tools are used extensively in the clinic for disease diagnosis, but have also found application in determining drug distribution and drug action in both humans and preclinical animal species. Their use in studying transporter med
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::166811df64be78f4c7001eee1f0f3ee3
https://doi.org/10.1039/9781782628705-00143
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6
Chapter 1. Emerging Transporter Science and Challenges for the Future
Autor: Glynis Nicholls, Kuresh Youdim
Given the importance of membrane transporters in drug pharmacokinetics, evaluating their potential interactions has become common practice for new chemical entities in the pharmaceutical industry. However, our knowledge base in this area is still inc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fe541349131fb20e408c1b28ea1f561
https://doi.org/10.1039/9781782628705-00001
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7
Chapter 1. Membrane Transporters: Fundamentals, Function and Their Role in ADME
Autor: John Keogh, Bruno Hagenbuch, Bruno Stieger, Caroline Rynn, Glynis Nicholls
The concept that membrane transport proteins could facilitate the flux of molecules across eukaryotic cell membranes was still in its infancy in the middle of the 20th century. Today, as our knowledge of this area of science has expanded, it is now r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3dee7772995ee483f0471137af00ef3
https://doi.org/10.1039/9781782623793-00001
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8
Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics
Autor: Dorien Groenendaal, Meindert Danhof, Jan Freijer, Elizabeth C. M. de Lange, Glynis Nicholls, Dennis de Mik, Andrea Rosier, Andrew Ayrton, Anne Hersey
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 34(2-3)
The objective of this investigation is to characterize the role of complex biophase distribution kinetics in the pharmacokinetic-pharmacodynamic correlation of a wide range of opioids. Following intravenous infusion of morphine, alfentanil, fentanyl,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52401460407f1dd7826460480f75f5d
https://pubmed.ncbi.nlm.nih.gov/18467078
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