Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Glyn Nelson"'
Autor:
David W P Dolan, Anze Zupanic, Glyn Nelson, Philip Hall, Satomi Miwa, Thomas B L Kirkwood, Daryl P Shanley
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 5, p e1004246 (2015)
Unrepaired or inaccurately repaired DNA damage can lead to a range of cell fates, such as apoptosis, cellular senescence or cancer, depending on the efficiency and accuracy of DNA damage repair and on the downstream DNA damage signalling. DNA damage
Externí odkaz:
https://doaj.org/article/f953f00fb1ac43ffb205b9a4ac4cb73d
Autor:
Piero Dalle Pezze, Glyn Nelson, Elsje G Otten, Viktor I Korolchuk, Thomas B L Kirkwood, Thomas von Zglinicki, Daryl P Shanley
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 8, p e1003728 (2014)
Cellular senescence, a state of irreversible cell cycle arrest, is thought to help protect an organism from cancer, yet also contributes to ageing. The changes which occur in senescence are controlled by networks of multiple signalling and feedback p
Externí odkaz:
https://doaj.org/article/92f0383807fb4d17a39a443dd0e5d2ad
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55190 (2013)
The presence of DNA double-stranded breaks in a mammalian cell typically activates the Non-Homologous End Joining (NHEJ) pathway to repair the damage and signal to downstream systems that govern cellular decisions such as apoptosis or senescence. The
Externí odkaz:
https://doaj.org/article/d5b4ba74bf394007a98fe443a502d4d6
Autor:
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e52989 (2013)
Most cancer cells express high levels of telomerase and proliferate indefinitely. In addition to its telomere maintenance function, telomerase also has a pro-survival function resulting in an increased resistance against DNA damage and decreased apop
Externí odkaz:
https://doaj.org/article/dd3634b84a304de89f73e0896e5700a1
Autor:
João F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L Kirkwood, Thomas von Zglinicki
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism. The pathways leading to esta
Externí odkaz:
https://doaj.org/article/c7825abd71494da28dc87edfd7c598df
Autor:
João F Passos, Gabriele Saretzki, Shaheda Ahmed, Glyn Nelson, Torsten Richter, Heiko Peters, Ilka Wappler, Matthew J Birket, Graham Harold, Karin Schaeuble, Mark A Birch-Machin, Thomas B L Kirkwood, Thomas von Zglinicki
Publikováno v:
PLoS Biology, Vol 5, Iss 5, p e110 (2007)
Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments. The replicative lifespan of primary human cells is telomere dependent; however, its he
Externí odkaz:
https://doaj.org/article/0dd6ed23b3284a848c8726777790a6a1
Autor:
Maximiliaan Huisman, James J. Chambers, Alex Laude, Peter Bajcsy, Ulrike Boehm, Caterina Strambio-De-Castillia, Damir Sudar, Orestis Faklaris, Glyn Nelson, Mathias Hammer, Nathalie Gaudreault, Farzin Farzam, Carlas Smith, Claire M. Brown, Roland Nitschke, Alexander D. Corbett, Judith Lacoste, Jaime A. Pimentel, Alison J. North, Alessandro Rigano, David Grunwald
Publikováno v:
Nat Methods
1 -ABSTRACTDigital light microscopy provides powerful tools for quantitatively probing the real-time dynamics of subcellular structures. While the power of modern microscopy techniques is undeniable, rigorous record-keeping and quality control are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbd113a5e98e72700c29cfdfd4a75ba
https://doi.org/10.1038/s41592-021-01327-9
https://doi.org/10.1038/s41592-021-01327-9
Autor:
Ian Dobbie, Erika Tse-Luen Wee, Laure Plantard, Xiang Hao, Claire Mitchell, Glyn Nelson, Judith Lacoste, Nadia Halidi, Alexander Corbett, Hella Hartmann, Yury Belyaev, Stanley Schwartz, Penghuan LIU, Rainer Heintzmann, Ioannis Alexopoulos, SANTOSH PODDER, Roland Nitschke, Laurent Gelman, Aurelien Dauphin, Alexander L. Payne-Dwyer
This protocol focuses on measuring the microscope's lateral and axial resolution, essential for reporting size measurements of near-resolution limit objects or distances between them. Here resolution is expressed as the Full Width at Half Maximum (FW
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e414d1da4a04eb5967843266d6e1bb
https://doi.org/10.17504/protocols.io.bp2l61ww1vqe/v1
https://doi.org/10.17504/protocols.io.bp2l61ww1vqe/v1
Autor:
John E Eriksson, Arne Seitz, Ian M. Dobbie, Caterina Strambio-De-Castillia, Jason R. Swedlow, Ali Gheisari, Miso Mitkovski, Alexia Ferrand, Roland Nitschke, Steve Bagley, Tobias M. Rasse, Glyn Nelson, Alex Laude, Peter Bajcsy, Alison J. North, Laurent Gelman, Julia Fernandez-Rodriguez, Ute Resch-Genger, Christian Kukat, Sebastian Munck, Claire M. Brown, Johanna Bischof, Ulrike Boehm, Hella Hartmann, Aurelien Dauphin, Lucas C Schuetz, Orestis Faklaris
Publikováno v:
Nat Methods
The community-driven initiative Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy (QUAREP-LiMi) wants to improve reproducibility for light microscopy image data through quality control (QC) management of instruments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305c5d6e4cd79792080dc29f1a401ace
https://doi.org/10.1038/s41592-021-01162-y
https://doi.org/10.1038/s41592-021-01162-y