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Acridone Alkaloids from Glycosmis chlorosperma as DYRK1A Inhibitors

Autor: Olivier Lozach, Laurent Meijer, Mehdi A. Beniddir, Khalijah Awang, Bogdan I. Iorga, Marc Litaudon, Erell Le Borgne, Nadège Loaëc

Publikováno v: Journal of Natural Products
Journal of Natural Products, 2014, 77 (5), pp.1117-1122. ⟨10.1021/np400856h⟩
Journal of Natural Products, American Chemical Society, 2014, 77 (5), pp.1117-1122. ⟨10.1021/np400856h⟩

Two new acridone alkaloids, chlorospermines A and B (1 and 2), were isolated from the stem bark of Glycosmis chlorosperma, together with the known atalaphyllidine (3) and acrifoline (4), by means of bioguided isolation using an in vitro enzyme assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4540b5b4bc83309c10b5d0b5f797927f
https://hal.science/hal-01162685

Synthesis of the tetracyclic core of chlorospermines

Autor: Ming Wan, Ang Li, Peng Yang, Jun-Yu Gong, Hua Liu, Ming Yao

Publikováno v: Chinese Chemical Letters. 26:272-276

Chlorospermines A and B are biologically interesting acridone natural products and recently isolated from Glycosmis chlorosperma . We report here a convergent approach to construct the tetracyclic core of the natural products. The two fragments are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3aff07bb1856df4b76df2405526fb85
https://doi.org/10.1016/j.cclet.2015.01.037

Prenylated flavanones and flavanonols as chemical markers in Glycosmis species (Rutaceae)

Autor: Brigitte Lukaseder, Wolfgang Robien, Harald Greger, Otmar Hofer, Michael Nagl, Christoph Seger, Srunya Vajrodaya, Gerda Lutz-Kutschera, Tina Hehenberger

Publikováno v: Phytochemistry. 70:1030-1037

Fifteen prenylated or geranylated flavanones and flavanonols were isolated from the leaf extracts of different Glycosmis species collected in Thailand and Malaysia. All structures were elucidated by spectroscopic methods, especially 1D and 2D NMR. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30999069300dfcf26dd82aec29a9045
https://doi.org/10.1016/j.phytochem.2009.05.007

Structure Elucidation and Synthesis of a New Bioactive Quinazolone Derivative Obtained from Glycosmis Cf. Chlorosperma

Autor: Otmar Hofer, Srunya Vajrodaya, Harald Greger, Christoph Seger

Publikováno v: Scopus-Elsevier

A new quinazolone derivative, (Z)-3, 4-dihydro-3-(2-phenylethenyl)-quinazolin-4-one, was isolated from Glycosmis cf. chlorsperma SPRENG. (Rutaceae). The structure was elucidated on the basis of spectroscopic data and confirmed by comparison with synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cfe4493fd136ce0745c17ff63adaf1
https://doi.org/10.1248/cpb.46.1926