Zobrazeno 1 - 10
of 25 993
pro vyhledávání: '"Glycosaminoglycan"'
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-12 (2024)
Abstract Objective Accumulation of extracellular matrix (ECM) proteins in the glomerular mesangial region is a typical hallmark of diabetic nephropathy (DN). However, the molecular mechanism underlying ECM accumulation in the mesangium of DN patients
Externí odkaz:
https://doaj.org/article/b7de771b463746229504589422e7b003
Autor:
Melissa Greenwood, Patricia Murciano-Martinez, Janet Berrington, Sabine L Flitsch, Sean Austin, Christopher Stewart
Publikováno v:
Microbial Cell, Vol 11, Pp 221-234 (2024)
Human breastmilk is composed of many well researched bioactive components crucial for infant nutrition and priming of the neonatal microbiome and immune system. Understanding these components gives us crucial insight to the health and wellbeing of in
Externí odkaz:
https://doaj.org/article/19cbad3120dc4fbeb6927aed5efb0922
Autor:
Joshua G. Dubowsky, Binoy Appukuttan, Evangeline Cowell, Valeria Sanders, David L. Gordon, Jillian M. Carr
Publikováno v:
Exploration of Immunology, Vol 4, Iss 3, Pp 376-393 (2024)
Aim: Severe dengue is correlated with a decrease in the circulating complement regulator, factor H (FH) and prior work has shown that dengue virus (DENV) infection induces FH mRNA but not FH protein release. Here, the mechanisms of this phenomenon we
Externí odkaz:
https://doaj.org/article/d24b43a508b04a51afea0962ba1905e2
Autor:
Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Age is a prominent risk factor for cardiometabolic disease, often leading to heart structural and functional changes. However, precise molecular mechanisms underlying cardiac remodeling and dysfunction exclusively resulting from physiologica
Externí odkaz:
https://doaj.org/article/0c2e46bf1dcf4c11bd67e3ee587a213f
Autor:
Lindsay Torrice, Elizabeth Jalazo
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 40, Iss , Pp 101113- (2024)
Fluoxetine has been identified as a potential treatment for mucopolysaccharidosis IIIA (MPS IIIA), a debilitating and progressive lysosomal storage disorder for which no treatments are approved. In the MPS IIIA mouse model, fluoxetine decreases the a
Externí odkaz:
https://doaj.org/article/478f8d2ffe214f94912fa4c392dea218
Autor:
Jing-Wen Li, Shao-Jia Mao, Yun-Qi Chao, Chen-Xi Hu, Yan-Jie Qian, Yang-Li Dai, Ke Huang, Zheng Shen, Chao-Chun Zou
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Mucopolysaccharidoses (MPSs) are caused by a deficiency in the enzymes needed to degrade glycosaminoglycans (GAGs) in the lysosome. The storage of GAGs leads to the involvement of several systems and even to the death of the patient. In rece
Externí odkaz:
https://doaj.org/article/6cdc2eb428394ae4831ded230cfa1afb
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 1933-1946 (2023)
In the past few decades, glycosaminoglycan (GAG) research has been crucial for gaining insights into various physiological, pathological, and therapeutic aspects mediated by the direct interactions between the GAG molecules and diverse proteins. The
Externí odkaz:
https://doaj.org/article/8c743831d28c400ead18196a59a6672e
Autor:
Dawei Wang, Yuyi Shi, Ziwen Cheng, Like Luo, Kuo Cheng, Shengqi Gan, Che Liu, Zeliang Chen, Baoling Yang
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
BackgroundToxoplasma gondii (T. gondii) is a widespread, zoonotic protozoan intracellular parasite with a complex life cycle, which can cause toxoplasmosis, a potentially serious disease. During the invasion process, T. gondii proteins first bind to
Externí odkaz:
https://doaj.org/article/f1030fe2004d479580e62d2a3a09c0c6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Proteoglycans (PGs), which have glycosaminoglycan chains attached to their protein cores, are essential for maintaining the morphology and function of healthy body tissues. Extracellular PGs perform various functions, classified into the following fo
Externí odkaz:
https://doaj.org/article/592173672a2d454d9db242e2818fb782
Autor:
Thomas Williams-Fegredo, Lee Davies, Carol Knevelman, Kyriacos Mitrophanous, James Miskin, Qasim A. Rafiq
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Both cell surface and soluble extracellular glycosaminoglycans have been shown to interfere with the exogenous nucleic acid delivery efficiency of non-viral gene delivery, including lipoplex and polyplex-mediated transfection. Most gene therapy viral
Externí odkaz:
https://doaj.org/article/30f18ce1f17f438ab64d69f10643272c