Glycoproteins, glycolipids, and proteoglycans [electronic resource] . Part B / edited by Martin I. Horowitz.

Externí odkaz: Kolekce e-knih KNAV Registrovani uzivatele: plny text online 5 minut, dalsi pristup na vyzadani. Registered users: full text online 5 minutes, further access on request.

An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts

Autor: Chukiat Tantiwong, Joanne L. Dunster, Rachel Cavill, Michael G. Tomlinson, Christoph Wierling, Johan W. M. Heemskerk, Jonathan M. Gibbins

Publikováno v: Scientific Reports, 13(1):3906. Nature Publishing Group

Receptor diffusion plays an essential role in cellular signalling via the plasma membrane microenvironment and receptor interactions, but the regulation is not well understood. To aid in understanding of the key determinants of receptor diffusion and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4cf2a4f65ff00b6e05de6de0861bfc
https://doi.org/10.1038/s41598-023-30884-6

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

Autor: Stefano Navarro, Andreas Starke, Johan W. M. Heemskerk, Marijke J. E. Kuijpers, David Stegner, Bernhard Nieswandt

Publikováno v: International journal of molecular sciences, 23(15):8610. Multidisciplinary Digital Publishing Institute (MDPI)

Glycoprotein (GP) VI is the major platelet collagen receptor and a promising anti-thrombotic target. This was first demonstrated in mice using the rat monoclonal antibody JAQ1, which completely blocks the Collagen-Related Peptide (CRP)-binding site o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f87dd8a3e620c5fbdfe64b54b50b03
https://doi.org/10.3390/ijms23158610

The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors

Autor: Jasmin Bartl, Marco Zanini, Flavia Bernardi, Antoine Forget, Lena Blümel, Julie Talbot, Daniel Picard, Nan Qin, Gabriele Cancila, Qingsong Gao, Soumav Nath, Idriss Mahoungou Koumba, Marietta Wolter, François Kuonen, Maike Langini, Thomas Beez, Christopher Munoz, David Pauck, Viktoria Marquardt, Hua Yu, Judith Souphron, Mascha Korsch, Christina Mölders, Daniel Berger, Sarah Göbbels, Frauke-Dorothee Meyer, Björn Scheffler, Barak Rotblat, Sven Diederichs, Vijay Ramaswamy, Hiromishi Suzuki, Anthony Oro, Kai Stühler, Anja Stefanski, Ute Fischer, Gabriel Leprivier, Dieter Willbold, Gerhard Steger, Alexander Buell, Marcel Kool, Peter Lichter, Stefan M. Pfister, Paul A. Northcott, Michael D. Taylor, Arndt Borkhardt, Guido Reifenberger, Olivier Ayrault, Marc Remke

Publikováno v: Nature Communications 13(1), 4061 (2022). doi:10.1038/s41467-022-31574-z
Nature communications, vol. 13, no. 1, pp. 4061
Bartl, J, Zanini, M, Bernardi, F, Forget, A, Blümel, L, Talbot, J, Picard, D, Qin, N, Cancila, G, Gao, Q, Nath, S, Koumba, I M, Wolter, M, Kuonen, F, Langini, M, Beez, T, Munoz, C, Pauck, D, Marquardt, V, Yu, H, Souphron, J, Korsch, M, Mölders, C, Berger, D, Göbbels, S, Meyer, F-D, Scheffler, B, Rotblat, B, Diederichs, S, Ramaswamy, V, Suzuki, H, Oro, A, Stühler, K, Stefanski, A, Fischer, U, Leprivier, G, Willbold, D, Steger, G, Buell, A, Kool, M, Lichter, P, Pfister, S M, Northcott, P A, Taylor, M D, Borkhardt, A, Reifenberger, G, Ayrault, O & Remke, M 2022, ' The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors ', Nature Communications, vol. 13, 4061 . https://doi.org/10.1038/s41467-022-31574-z
Nature Communications
Nature Communications, 2022, 13 (1), pp.4061. ⟨10.1038/s41467-022-31574-z⟩

Most lncRNAs display species-specific expression patterns suggesting that animal models of cancer may only incompletely recapitulate the regulatory crosstalk between lncRNAs and oncogenic pathways in humans. Among these pathways, Sonic Hedgehog (SHH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ec632d06d6284086a564a448ef81a7
https://hdl.handle.net/2128/31691

Neglecting plasma protein binding in COVID-19 patients leads to a wrong interpretation of lopinavir overexposure

Autor: Caroline Solas, E. Meriglier, Stéphane Bouchet, Françoise Stanke-Labesque, Elodie Gautier-Veyret, Carole Schwebel, Peggy Gandia, Zoubir Djerada, Olivier Epaulard, Guillaume Martin-Blondel, Stéphanie Ruiz, Didier Concordet, Fabrice Bonnet, Bruno Mourvillier

Publikováno v: Clinical Pharmacology & Therapeutics
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 2021, Therapeutic Innovations in Infectious Diseases, 109 (4), pp.1030-1033. ⟨10.1002/cpt.2196⟩
Clinical Pharmacology and Therapeutics, American Society for Clinical Pharmacology and Therapeutics, 2021, Therapeutic Innovations in Infectious Diseases, 109 (4), pp.1030-1033. ⟨10.1002/cpt.2196⟩

Boffito et al. recalled the critical importance to correctly interpret protein binding. Changes of lopinavir pharmacokinetics in coronavirus disease 2019 (COVID-19) are a perfect illustration. Indeed, several studies described that total lopinavir pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97f4bd4d018c78cd6f5d100aaabd7f9
http://hdl.handle.net/20.500.12278/26884