Zobrazeno 1 - 10
of 852
pro vyhledávání: '"Glycogen synthase kinase 3β"'
Autor:
Yanhong Zheng, Yang Yang, Weiyan Zhu, Ruhao Liu, Aodong Liu, Runfeng Zhang, Weixing Lei, Shifeng Huang, Yongzhu Liu, Qinglan Hu
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 57 (2024)
Previous studies show that glycogen synthase kinase 3β (GSK3B) plays an important role in tumorigenesis. However, its role in cervical cancer is unclear. The present study silenced GSK3B with siRNAs and/or chemical inhibitors to determine its role i
Externí odkaz:
https://doaj.org/article/e043181308e84ace9871d7ebb6e545a8
Autor:
Xinyi Zhang, Weiwei Zhao, Feilong Wang, Wei Zhao, Liang Hu, Zhendong Xie, Xueyan Zhu, Peng Zhang, Yong Chu
Publikováno v:
Results in Chemistry, Vol 8, Iss , Pp 101553- (2024)
Glycogen synthase kinase-3β (GSK-3β) has been identified to promote inflammation and its inhibitors have also been proven to treat some inflammatory-mediated diseases in animal models. Allosteric inhibitors inherently have better therapeutical valu
Externí odkaz:
https://doaj.org/article/0bcfc659b17646bbba4ed17b6e7f5d39
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 6941-6957 (2023)
Tauopathy is a neurodegenerative condition associated with oligomeric tau formation through abnormal phosphorylation. We previously showed that tauopathy is involved in death of retinal ganglion cells (RGCs) after optic nerve crush (ONC). It has been
Externí odkaz:
https://doaj.org/article/9ef8ead249884861be1b9ef086a3abeb
Autor:
Nicholas O. Schneider, Kendra Gilreath, Daniel J. Burkett, Martin St. Maurice, William A. Donaldson
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 570 (2024)
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase which plays a center role in the phosphorylation of a wide variety of proteins, generally leading to their inactivation. As such, GSK-3 is viewed as a therapeutic target. An ever-increas
Externí odkaz:
https://doaj.org/article/cead14d4c2924495a6cb574a90aa61a1
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 6, Pp 1347-1353 (2023)
Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer’s disease mouse models and patients, and that it plays a vital role in the learning and memory. However, the underlying mechanisms of fibro
Externí odkaz:
https://doaj.org/article/724837acef0348e6a895f13ff9650e64
Publikováno v:
Journal of Ginseng Research, Vol 46, Iss 5, Pp 666-674 (2022)
Background: Ginsenosides and their metabolites have antidepressant-like effects, but the underlying mechanisms remain unclear. We previously identified 14-3-3 ζ as one of the target proteins of 20 (S)-protopanaxadiol (PPD), a fully deglycosylated gi
Externí odkaz:
https://doaj.org/article/88fe4e92d082479c95d6c55db4a02025
Autor:
Fabio Squarcio, Timna Hitrec, Emiliana Piscitiello, Matteo Cerri, Catia Giovannini, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/47609ced8bba432a94194ce83d8d0a9c
Autor:
Yiwen Liu, Fuyou Zhou, Haijun Yang, Zheyuan Zhang, Jiahao Zhang, Keyao He, Mengfan Qian, Ruonan Li, Wei Sun, Ningtao Dai, Junkuo Li, Yibo Guo, Jinyu Kong, Shegan Gao
Publikováno v:
Translational Oncology, Vol 32, Iss , Pp 101656- (2023)
Our prior studies have confirmed that long-term colonization of Porphyromonas gingivalis (Pg) and overexpression of the inflammatory factor glycogen synthase kinase 3β (GSK3β) promote the malignant evolution of esophageal squamous cell carcinoma (E
Externí odkaz:
https://doaj.org/article/c4c447ebe47648fc81ee4586e7422a69
Akademický článek
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Autor:
Fabio Squarcio, Timna Hitrec, Emiliana Piscitiello, Matteo Cerri, Catia Giovannini, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Luppi
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Hyperphosphorylated Tau protein (PPTau) is the hallmark of tauopathic neurodegeneration. During “synthetic torpor” (ST), a transient hypothermic state which can be induced in rats by the local pharmacological inhibition of the Raphe
Externí odkaz:
https://doaj.org/article/2add5cb63b90442fb366d59effa2e371