Výsledky vyhledávání - "GlyNAC supplementation"

Akademický článek

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

Autor: Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles Minard, Farook Jahoor, Rajagopal V. Sekhar

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 3, Pp n/a-n/a (2021)

Abstract Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel‐oxidation (MFO), elevated inflammat

Externí odkaz: https://doaj.org/article/c0f273d8e34c47f1be8231c38abb59db

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Akademický článek

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GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging

Autor: Rajagopal V. Sekhar

Publikováno v: The Journal of nutrition. 151(12)

Cellular increases in oxidative stress (OxS) and decline in mitochondrial function are identified as key defects in aging, but underlying mechanisms are poorly understood and interventions are lacking. Defects linked to OxS and impaired mitochondrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a03502d48eb0def9a102a3e9d220ba6
https://pubmed.ncbi.nlm.nih.gov/34587244

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Autor: Rajagopal V. Sekhar, Farook Jahoor, Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles G. Minard

Publikováno v: Clinical and Translational Medicine
Clinical and Translational Medicine, Vol 11, Iss 3, Pp n/a-n/a (2021)

Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel‐oxidation (MFO), elevated inflammation, endo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd0390be59ec9dda604727f05029be9
https://doi.org/10.1002/ctm2.372

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Akademický článek

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging

Autor: Premranjan Kumar, Ob W. Osahon, Rajagopal V. Sekhar

Publikováno v: Antioxidants, Vol 12, Iss 5, p 1042 (2023)

Cognitive decline frequently occurs with increasing age, but mechanisms contributing to age-associated cognitive decline (ACD) are not well understood and solutions are lacking. Understanding and reversing mechanisms contributing to ACD are important

Externí odkaz: https://doaj.org/article/47a92a2a55f149c7ba6fe1743ed569df

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