Zobrazeno 1 - 10
of 2 518
pro vyhledávání: '"Glutamate uptake"'
Publikováno v:
eLife, Vol 13 (2024)
Ischemia leads to a severe dysregulation of glutamate homeostasis and excitotoxic cell damage in the brain. Shorter episodes of energy depletion, for instance during peri-infarct depolarizations, can also acutely perturb glutamate signaling. It is le
Externí odkaz:
https://doaj.org/article/5cfb633bde8249dca841a174ef157cc7
Autor:
Vanda Balint, Mina Peric, Sanja Dacic, Danijela Stanisavljevic Ninkovic, Jelena Marjanovic, Jelena Popovic, Milena Stevanovic, Andrijana Lazic
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 796 (2024)
Astrocytes are the main homeostatic cells in the central nervous system, with the unique ability to transform from quiescent into a reactive state in response to pathological conditions by reacquiring some precursor properties. This process is known
Externí odkaz:
https://doaj.org/article/c540c79e766544618835a642e97b5096
Autor:
Hemil Gonzalez, Srinivas D. Narasipura, Tanner Shull, Amogh Shetty, Tara L. Teppen, Ankur Naqib, Lena Al-Harthi
Publikováno v:
Cells, Vol 12, Iss 19, p 2357 (2023)
Human inducible pluripotent stem cell (hiPSC)-derived astrocytes (iAs) are critical to study astrocytes in health and disease. They provide several advantages over human fetal astrocytes in research, which include consistency, availability, disease m
Externí odkaz:
https://doaj.org/article/80b235d534ec4e70a016264a8dceb9f1
Autor:
Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta
Publikováno v:
Cells, Vol 12, Iss 12, p 1592 (2023)
Owing to the presence of multiple enzymatic domains, LRRK2 has been associated with a diverse set of cellular functions and signaling pathways. It also has several pathological mutant-variants, and their incidences show ethnicity biases and drug-resp
Externí odkaz:
https://doaj.org/article/91ba1c00c5394265940cddbc2cf6e994
Publikováno v:
Cells, Vol 12, Iss 12, p 1610 (2023)
Once outside the synaptic cleft, the excitatory neurotransmitter glutamate is rapidly bound by its high-affinity transporters, which are expressed in abundance on the surface of perisynaptic astroglia. While this binding and the subsequent uptake of
Externí odkaz:
https://doaj.org/article/f782db8686824534ab06180e7489f474
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 1083-1089 (2020)
Astrocytic aquaporin 4 (AQP4) facilitates glutamate clearance via regulation of the glutamate transporter function, involved in the modulation of brain plasticity and cognitive function to prevent neurodegenerative disorders such as Alzheimer’s dis
Externí odkaz:
https://doaj.org/article/7cb5c78ba7324e7c83c2eaabba3bbe5f
Autor:
Pauline Beckers, Olaya Lara, Ines Belo do Nascimento, Nathalie Desmet, Ann Massie, Emmanuel Hermans
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases and has been frequently correlated with the altered expression and/or function of astrocytic high-affinity glutamate transporters. There is, however, a growing
Externí odkaz:
https://doaj.org/article/3e26255d1138482bbd2b40219b0d57ef
Akademický článek
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Autor:
Qiong Zhou, Coralie Viollet, Anastasia Efthymiou, Guzal Khayrullina, Kasey E. Moritz, Matthew D. Wilkerson, Gauthaman Sukumar, Clifton L. Dalgard, Martin L. Doughty
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Astrocytes respond to central nervous system (CNS) injury and disease by transforming to a reactive astrogliosis cell state that can contribute to either CNS dysfunction or repair. Neuroinflammation is a powerful driver of a harmf
Externí odkaz:
https://doaj.org/article/27bc7001b96044c4a0c8c26733e3dc5a