Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Glutamate secretion"'
Autor:
Iffat Tariq, Shahana S. Mahajan, Thongthai Thavornwatanayong, Cassey Tam, Sonam Lhamo, Angelina Blyufer
Publikováno v:
International Journal of Oncology
Riluzole, a glutamate release inhibitor, has been in use for the treatment of amyotrophic lateral sclerosis for over two decades since its approval by the Food and Drug Administration. Recently, riluzole has been evaluated in cancer cells and indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e864a8b0ab70a97ae1916bc71ba51443
https://doi.org/10.3892/ijo.2021.5275
https://doi.org/10.3892/ijo.2021.5275
Autor:
Kody Paul Mansfield, Shruti Naik
Publikováno v:
Cell
Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical and functional associations with sensory afferent neurons. We reveal that epidermal nerve endings from a subset of sensory nonpeptidergic neurons expressing MrgprD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c798301c65e1d6531ede927b3bfac8
https://doi.org/10.1016/j.cell.2021.03.040
https://doi.org/10.1016/j.cell.2021.03.040
Autor:
Gurmit Singh, Jennifer Fazzari
Publikováno v:
Breast Cancer: Targets and Therapy. 11:273-282
Purpose The complex nature of cancer-induced bone pain (CIBP) has led to investigation into cancer-targeted therapies. This has involved targeting glutamate release from the tumor, secreted as a byproduct of antioxidant responses and metabolic disrup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a1091d99bc59841edd47d511ae237a
https://doi.org/10.2147/bctt.s215655
https://doi.org/10.2147/bctt.s215655
Autor:
Bruce G. Haffty, Stephanie LaCava, Shabbar F. Danish, Devora Schiff, Atif J. Khan, Sachin R. Jhawar, Suzie Chen, Monal Mehta, Aditya Thandoni
Publikováno v:
Oncotarget. 10:2824-2834
// Atif J. Khan 1 , 2 , Stephanie LaCava 2 , 3 , Monal Mehta 2 , Devora Schiff 2 , Aditya Thandoni 2 , Sachin Jhawar 2 , Shabbar Danish 4 , Bruce G. Haffty 2 and Suzie Chen 3 1 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b697ab8812c6335840cb287e9265bce1
https://doi.org/10.18632/oncotarget.26854
https://doi.org/10.18632/oncotarget.26854
Autor:
Xiangxiang Wang, Tianqing Ding, Wencai Li, Xuanke Hong, Yinsheng Chen, Li Wang, Wenchao Duan, Dongling Pei, Chen Sun, Jing Yan, Shenghai Zhang, Weiwei Wang, Zhen-Yu Zhang, Yunbo Zhan, Zhicheng Li, Zhen Liu, Jingliang Cheng, Yu Guo, Xianzhi Liu, Lei Liu, Yuanshen Zhao, Wenqing Wang, Haibiao Zhao, Xiaofei Lv, Qiuchang Sun, Tao Sun
Publikováno v:
EBioMedicine
EBioMedicine, Vol 72, Iss, Pp 103583-(2021)
EBioMedicine, Vol 72, Iss, Pp 103583-(2021)
Background: To develop and validate a deep learning signature (DLS) from diffusion tensor imaging (DTI) for predicting overall survival in patients with infiltrative gliomas, and to investigate the biological pathways underlying the developed DLS. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9b054c5ef9229827f3e793a4fae647
https://pubmed.ncbi.nlm.nih.gov/34563923
https://pubmed.ncbi.nlm.nih.gov/34563923
Autor:
Daniel P. Radin, Stella E. Tsirka
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8476, p 8476 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 8476, p 8476 (2020)
Despite significant strides made in understanding the pathophysiology of high-grade gliomas over the past two decades, most patients succumb to these neoplasias within two years of diagnosis. Furthermore, there are various co-morbidities associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fc94b3eeb6b48fe1d4b6820ec62d23
http://europepmc.org/articles/PMC7698134
http://europepmc.org/articles/PMC7698134
Autor:
Ana Magalhães, Teresa Canedo, Renata L. Alves, Ana M. F. P. Silva, Sandra H. Vaz, Tiago Almeida, Renato Socodato, Cátia M. Silva, Ana M. Sebastião, João B. Relvas, António F. Ambrósio, Cord Brakebusch, Joana F. Henriques, Roberto Paes-de-Carvalho, Teresa Summavielle, Filipa I. Baptista, João P. Magalhães, Artur Rodrigues, Camila C. Portugal, Vanessa Coelho-Santos
Publikováno v:
Socodato, R, Portugal, C C, Canedo, T, Rodrigues, A, Almeida, T O, Henriques, J F, Vaz, S H, Magalhães, J, Silva, C M, Baptista, F I, Alves, R L, Coelho-Santos, V, Silva, A P, Paes-de-Carvalho, R, Magalhães, A, Brakebusch, C, Sebastião, A M, Summavielle, T, Ambrósio, A F & Relvas, J B 2020, ' Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration ', Cell Reports, vol. 31, no. 12, 107796, pp. 1-29 . https://doi.org/10.1016/j.celrep.2020.107796
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
© 2020 The Author(s). Creative Commons Attribution (CC BY 4.0)
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb571fceba1952acaecbe0bcbe6bc791
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
Autor:
Rolf Graf, Simone M. R. Camargo, Selene Araya, Evelyne Kuster, Theresia Reding, Christian Lutz, Dino Gluch, François Verrey, Luca Mariotta
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 314:G517-G536
Glutamine (Gln) is the most concentrated amino acid in blood and considered conditionally essential. Its requirement is increased during physiological stress, such as malnutrition or illness, despite its production by muscle and other organs. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4541ea9387a67541a21686f389bde896
https://doi.org/10.1152/ajpgi.00135.2017
https://doi.org/10.1152/ajpgi.00135.2017
Autor:
C Salesse
Publikováno v:
Journal Français d'Ophtalmologie. 40:239-250
The retinal photoreceptors (rods and cones) are responsible for light absorption and transduction of the signal, which is transmitted to the other retinal nerve cells and then to the brain. The chromophore of visual pigments of rods and cones is a pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c701b3cc033df5cf22fa4615ec19c67
https://doi.org/10.1016/j.jfo.2016.12.006
https://doi.org/10.1016/j.jfo.2016.12.006
Autor:
Enrique Sentandreu, José V. Castell, Maria Isabel Alcoriza-Balaguer, Antonio Pineda-Lucena, Agustín Lahoz, Miguel Bolonio, Roque Bort, Giovanna Luongo, Ramon Santamaria, Martina Palomino-Schätzlein, Maria Ballester
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
SCIENTIFIC REPORTS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Scientific Reports
SCIENTIFIC REPORTS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Scientific Reports
Human dermal fibroblasts can be reprogrammed into hepatocyte-like (HEP-L) cells by the expression of a set of transcription factors. Yet, the metabolic rewiring suffered by reprogrammed fibroblasts remains largely unknown. Here we report, using stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edebe1e1e77ed287a390886b8713eb3
https://doi.org/10.1038/s41598-019-54357-x
https://doi.org/10.1038/s41598-019-54357-x