Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Glucose/genetics/metabolism"'
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Autor:
Peter Orchard, Jocelyn E. Manning Fox, Anthony Payne, Karen L. Mohlke, Laura J. Scott, Nikolay Oskolkov, Anubha Mahajan, Andrew A. Brown, Apoorva K Iyengar, Paul Johnson, Ola Hansson, Patrick E. MacDonald, Michael L. Stitzel, Ulrika Krus, Ana Viñuela, Cédric Howald, Narisu Narisu, Gad Hatem, Anna L. Gloyn, Nikolaos I Panousis, Michael R. Erdos, Leif Groop, Vibe Nylander, Olof Asplund, João Fadista, Francis S. Collins, Emmanouil T. Dermitzakis, Amanda J. Bennett, Swarooparani Vadlamudi, Arushi Varshney, Rashmi B. Prasad, Stephen C. J. Parker, Mark I. McCarthy, Michael Boehnke, Martijn van de Bunt, Ryan P. Welch
Publikováno v:
Nature Communications, Vol. 11, No 1 (2020) P. 4912
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from large-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a13e4756f7dc1e58a1b08e7a9f4874
https://archive-ouverte.unige.ch/unige:144670
https://archive-ouverte.unige.ch/unige:144670
Autor:
Iglesias José, Barg Sebastian, Vallois David, Lahiri Shawon, Roger Catherine, Yessoufou Akadiri, Pradevand Sylvain, McDonald Angela, Bonal Claire, Reimann Frank, Gribble Fiona, Debril Marie Bernard, Metzger Daniel, Chambon Pierre, Herrera Pedro, Rutter Guy A., Prentki Marc, Thorens Bernard, Wahli Walter
Publikováno v:
The Journal of clinical investigation
Journal of Clinical Investigation, Vol. 122, No 11 (2012) pp. 4105-17
Journal of Clinical Investigation
Journal of Clinical Investigation, Vol. 122, No 11 (2012) pp. 4105-17
Journal of Clinical Investigation
PPARβ/δ protects against obesity by reducing dyslipidemia and insulin resistance via effects in muscle, adipose tissue, and liver. However, its function in pancreas remains ill defined. To gain insight into its hypothesized role in β cell function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d320ba819c1297d8242136e012303cc
Autor:
Yves Benoît Mattenberger, Kyu Sang Park, Piero Marchetti, Andreas Wiederkehr, Jean-Claude Martinou, Clare L. Kirkpatrick, Nicolas Demaurex, Claes B. Wollheim
Publikováno v:
Journal of Biological Chemistry, Vol. 283, No 48 (2008) pp. 33347-56
Mitochondria form filamentous networks that undergo continuous fission/fusion. In the pancreatic β-cells, mitochondria are essential for the transduction of signals linking nutrient metabolism to insulin granule exocytosis. Here we have studied mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a957684c2f41402177f10d43d1a4370
https://pubmed.ncbi.nlm.nih.gov/18832378
https://pubmed.ncbi.nlm.nih.gov/18832378