Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Design, synthesis, and pharmacological evaluation of 2-(4-sulfonylphenyl)-2-[(E)-pyrrolidin-1-ylimino]-N-thiazoleacetamides as glucokinase activators

Autor: Tetsuji Matsudaira, Kosuke Yasuda, Rikiya Ohashi, Hiromitsu Takayama, Hideyuki Yanagisawa, Hiroshi Sugama, Masao Nawano

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 30:127249

This paper presents the synthesis and glucokinase activity of novel hydrazone derivatives. The 2-(4-cyclopropylsulfonylphenyl)-2-[(E)-pyrrolidin-1-ylimino]-acetamide derivatives 5a-5h presented the in vitro glucokinase activities and in vivo blood gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f253f68ceb6709ca5d0bcf4babd080
https://doi.org/10.1016/j.bmcl.2020.127249

Liver glucokinase: An overview on the regulatorymechanisms of its activity

Autor: Flavio Francini, María Laura Massa, Juan José Gagliardino

Publikováno v: IUBMB Life. 63:1-6

Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839afc04444cdc6f51d2c64ab052d909
https://doi.org/10.1002/iub.411

Oat beta-glucan ameliorates insulin resistance in mice fed on high-fat and high-fructose diet

Autor: Jie Zheng, Shuanghui Wang, Nanhui Shen, Guohua Zhao

Publikováno v: Food & Nutrition Research, Vol 57, Iss 0, Pp 1-7 (2013)
Food & Nutrition Research; Vol 57 (2013) incl Supplements
Food & Nutrition Research

Methods : This study sought to evaluate the impact of oat beta-glucan on insulin resistance in mice fed on high-fat and high-fructose diet with fructose (10%, w/v) added in drinking water for 10 weeks. Results : The results showed that supplementatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a19756517fee6dc49eea72d13c2f0f5
http://www.foodandnutritionresearch.net/index.php/fnr/article/download/22754/31599

Design, synthesis and biological evaluation of novel glucokinase activators

Autor: Quan Liu, Yu Liang Zhang, Yu Ling Wang, Sheng Quan Hu, Yong Qiang Li, Zhiqiang Feng, Zhu Fang Shen, Lei Lei, Hong Rui Song

Publikováno v: Chinese Chemical Letters. 22:73-76

A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure–activity relationship (SAR) is di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c35bdd5a1e722d92a16e9e40ecab751
https://doi.org/10.1016/j.cclet.2010.07.023