Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Glucagon/metabolism"'
Autor:
Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider
Publikováno v:
The Biochemical journal, Vol. 479, no.12, p. 1317-1336 (2022)
Pharmacological AMPK activation represents an attractive approach for the treatment of type 2 diabetes (T2D). AMPK activation increases skeletal muscle glucose uptake, but there is controversy as to whether AMPK activation also inhibits hepatic gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aac092c3c348fbc7d9f09e908c72f48
https://doi.org/10.1042/bcj20220170
https://doi.org/10.1042/bcj20220170
Autor:
Michael M. Richter, Maria S. Svane, Viggo B. Kristiansen, Jens J. Holst, Sten Madsbad, Kirstine N. Bojsen-Møller
Publikováno v:
Richter, M M, Svane, M S, Kristiansen, V B, Holst, J J, Madsbad, S & Bojsen-Møller, K N 2023, ' Postprandial secretion of follistatin after gastric bypass surgery and sleeve gastrectomy ', Peptides, vol. 163, 170978 . https://doi.org/10.1016/j.peptides.2023.170978
Follistatin is secreted from the liver and may regulate muscle growth and insulin sensitivity. Protein intake stimulates follistatin secretion, which may be mediated by increased glucagon in the context of low insulin concentrations. We investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b481ee8c5a3122bc48149b35dcdcc45d
https://curis.ku.dk/ws/files/340116539/1_s2.0_S0196978123000402_main.pdf
https://curis.ku.dk/ws/files/340116539/1_s2.0_S0196978123000402_main.pdf
Autor:
Abarkan, Myriam, GAITAN, Julien, Lebreton, Fanny, Perrier, Romain, Jaffredo, Manon, Mulle, Christophe, Magnan, Christophe, Raoux, Matthieu, Lang, Jochen
Publikováno v:
Molecular Metabolism, Vol 30, Iss, Pp 152-160 (2019)
Molecular Metabolism
Molecular Metabolism, Vol. 30 (2019) pp. 152-160
Molecular metabolism
Molecular metabolism, Elsevier, 2019, 30, pp.152-160. ⟨10.1016/j.molmet.2019.09.011⟩
Molecular metabolism, 2019, 30, pp.152-160. ⟨10.1016/j.molmet.2019.09.011⟩
Molecular Metabolism
Molecular Metabolism, Vol. 30 (2019) pp. 152-160
Molecular metabolism
Molecular metabolism, Elsevier, 2019, 30, pp.152-160. ⟨10.1016/j.molmet.2019.09.011⟩
Molecular metabolism, 2019, 30, pp.152-160. ⟨10.1016/j.molmet.2019.09.011⟩
Objective Islets secrete neurotransmitters including glutamate which participate in fine regulation of islet function. The excitatory ionotropic glutamate receptor GluK2 of the kainate receptor family is widely expressed in brain and also found in is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::313ed053ef19c0bd822975f3979cb1a1
http://www.sciencedirect.com/science/article/pii/S2212877819309147
http://www.sciencedirect.com/science/article/pii/S2212877819309147
Autor:
Amalie R. Lanng, Ulrik Becker, Jens J. Holst, Tina Vilsbøll, Joachim Knop, Sigrid Bergmann, Jonatan I. Bagger, Lærke S. Gasbjerg, Lise Gether, Niels B. Dalsgaard, Magnus F. Grøndahl, Signe Foghsgaard, Matthew P. Gillum, Mia Demant, Malte P. Suppli, Nicolai J. Wewer Albrechtsen, Merete J Kønig, Charlotte Strandberg, Henning Grønbæk, Martin L. Thomasen, Filip K. Knop
Publikováno v:
Demant, M, Suppli, M P, Foghsgaard, S, Gether, L, Grøndahl, M F G, Dalsgaard, N B, Bergmann, S S, Lanng, A R, Gasbjerg, L S, Thomasen, M, Bagger, J I, Strandberg, C, Kønig, M J, Grønbæk, H, Becker, U, Wewer Albrechtsen, N J, Holst, J J, Knop, J, Gillum, M P, Vilsbøll, T & Knop, F K 2021, ' Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults ', European Journal of Endocrinology, vol. 185, no. 1, pp. 23-32 . https://doi.org/10.1530/EJE-21-0122
Demant, M, Suppli, M P, Foghsgaard, S, Gether, L, Grøndahl, M F G, Dalsgaard, N B, Bergmann, S S, Lanng, A R, Gasbjerg, L S, Thomasen, M, Bagger, J I, Strandberg, C, Kønig, M J, Grønbæk, H, Becker, U, Holst, J J, Knop, J, Gillum, M P, Vilsbøll, T & Knop, F K 2021, ' Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults ', European Journal of Endocrinology, vol. 185, no. 1, pp. 23-32 . https://doi.org/10.1530/EJE-21-0122
Demant, M, Suppli, M P, Foghsgaard, S, Gether, L, Grøndahl, M F G, Dalsgaard, N B, Bergmann, S S, Lanng, A R, Gasbjerg, L S, Thomasen, M, Bagger, J I, Strandberg, C, Kønig, M J, Grønbæk, H, Becker, U, Holst, J J, Knop, J, Gillum, M P, Vilsbøll, T & Knop, F K 2021, ' Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults ', European Journal of Endocrinology, vol. 185, no. 1, pp. 23-32 . https://doi.org/10.1530/EJE-21-0122
Aims/hypothesis Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6360ee13ff03cdf01cb4fca67796d4
https://doi.org/10.1530/eje-21-0122
https://doi.org/10.1530/eje-21-0122
Autor:
Sara Heebøll, Jeyanthini Risikesan, Steffen Ringgaard, Indumathi Kumarathas, Thomas D. Sandahl, Henning Grønbæk, Esben Søndergaard, Søren Nielsen
Publikováno v:
Heebøll, S, Risikesan, J, Ringgaard, S, Kumarathas, I, Sandahl, T D, Grønbæk, H, Søndergaard, E & Nielsen, S 2022, ' Impaired Glucagon-Mediated Suppression of VLDL-triglyceride Secretion in Individuals with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) ', Diabetes, vol. 71, no. 11 . https://doi.org/10.2337/db22-0313
Individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) have elevated plasma lipids as well as glucagon, although glucagon suppresses hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion. We hypothesize that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe248b1095bb9fc89bf70b317911f86
https://pubmed.ncbi.nlm.nih.gov/36001750
https://pubmed.ncbi.nlm.nih.gov/36001750
Autor:
Thorens, B.
Publikováno v:
Journal of diabetes investigation, vol. 13, no. 4, pp. 599-607
Hypoglycemia almost never develops in healthy individuals, because multiple hypoglycemia sensing systems, located in the periphery and in the central nervous system, trigger a coordinated counterregulatory hormonal response to restore normoglycemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1900::303643cb78948659f565be3dc5270f10
https://serval.unil.ch/resource/serval:BIB_F099AC71737F.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_F099AC71737F.P001/REF.pdf
Autor:
Kaare V. Grunddal, Samuel A. J. Trammell, Cecilie Bæch-Laursen, Daniel B. Andersen, Stella F. S. Xu, Helle Andersen, Matthew P. Gillum, Seyed M. Ghiasi, Ivana Novak, Björn Tyrberg, Chien Li, Mette M. Rosenkilde, Bolette Hartmann, Jens J. Holst, Rune E. Kuhre
Publikováno v:
Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, no. 6, pp. 1018-1031 . https://doi.org/10.1007/s00125-022-05675-9
Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, pp. 1018–1031 . https://doi.org/10.1007/s00125-022-05675-9
Grunddal, K V, Trammell, S A J, Bæch-Laursen, C, Andersen, D B, Xu, S F S, Andersen, H, Gillum, M P, Ghiasi, S M, Novak, I, Tyrberg, B, Li, C, Rosenkilde, M M, Hartmann, B, Holst, J J & Kuhre, R E 2022, ' Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats ', Diabetologia, vol. 65, pp. 1018–1031 . https://doi.org/10.1007/s00125-022-05675-9
Aim/hypothesis Urocortin-3 (UCN3) is a glucoregulatory peptide produced in the gut and pancreatic islets. The aim of this study was to clarify the acute effects of UCN3 on glucose regulation following an oral glucose challenge and to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658a8f06433bf32dc32bc8cf4b917233
https://pubmed.ncbi.nlm.nih.gov/35325259
https://pubmed.ncbi.nlm.nih.gov/35325259
Publikováno v:
BASE-Bielefeld Academic Search Engine
Hædersdal, S, Lund, A, Knop, F K & Vilsbøll, T 2018, ' The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes ', Mayo Clinic Proceedings, vol. 93, no. 2, pp. 217-239 . https://doi.org/10.1016/j.mayocp.2017.12.003
Hædersdal, S, Lund, A, Knop, F K & Vilsbøll, T 2018, ' The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes ', Mayo Clinic Proceedings, vol. 93, no. 2, pp. 217-239 . https://doi.org/10.1016/j.mayocp.2017.12.003
Type 2 diabetes is a disease involving both inadequate insulin levels and increased glucagon levels. While glucagon and insulin work together to achieve optimal plasma glucose concentrations in healthy individuals, the usual regulatory balance betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653dac3c7ce511366000f9f40d1ae410
https://doi.org/10.1016/j.mayocp.2017.12.003
https://doi.org/10.1016/j.mayocp.2017.12.003
Autor:
Nicolai J. Wewer Albrechtsen, Fiona M. Gribble, Nils Wierup, Seyed Mojtaba Ghiasi, Lihua Chen, Jens J. Holst, Alexander Aivazidis, Alice E. Adriaenssens, Frank Reimann, Cathrine Ørskov, Thomas Mandrup-Poulsen, Daniel B. Andersen, Björn Tyrberg, Rune E. Kuhre
Publikováno v:
Kuhre, R E, Ghiasi, S M, Adriaenssens, A E, Wewer Albrechtsen, N J, Andersen, D B, Aivazidis, A, Chen, L, Mandrup-Poulsen, T, Ørskov, C, Gribble, F M, Reimann, F, Wierup, N, Tyrberg, B & Holst, J J 2019, ' No direct effect of SGLT2 activity on glucagon secretion ', Diabetologia, vol. 62, no. 6, pp. 1011-1023 . https://doi.org/10.1007/s00125-019-4849-6
Kuhre, R E, Ghiasi, S M, Adriaenssens, A E, Albrechtsen, N J W, Andersen, D B, Aivazidis, A, Chen, L, Mandrup-Poulsen, T, Ørskov, C, Gribble, F M, Reimann, F, Wierup, N, Tyrberg, B & Holst, J J 2019, ' No direct effect of SGLT2 activity on glucagon secretion ', Diabetologia, vol. 62, no. 6, pp. 1011-1023 . https://doi.org/10.1007/s00125-019-4849-6
Kuhre, R E, Ghiasi, S M, Adriaenssens, A E, Albrechtsen, N J W, Andersen, D B, Aivazidis, A, Chen, L, Mandrup-Poulsen, T, Ørskov, C, Gribble, F M, Reimann, F, Wierup, N, Tyrberg, B & Holst, J J 2019, ' No direct effect of SGLT2 activity on glucagon secretion ', Diabetologia, vol. 62, no. 6, pp. 1011-1023 . https://doi.org/10.1007/s00125-019-4849-6
AIMS/HYPOTHESIS: Sodium-glucose cotransporter (SGLT) 2 inhibitors constitute a new class of glucose-lowering drugs, but they increase glucagon secretion, which may counteract their glucose-lowering effect. Previous studies using static incubation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934517c937b7619946a77c323475cedd
https://pure.au.dk/portal/da/publications/no-direct-effect-of-sglt2-activity-on-glucagon-secretion(b93ef495-273f-4f6c-b177-09dbda8a64f0).html
https://pure.au.dk/portal/da/publications/no-direct-effect-of-sglt2-activity-on-glucagon-secretion(b93ef495-273f-4f6c-b177-09dbda8a64f0).html
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 110, Iss, Pp 609-617 (2019)
Background Diabetes mellitus become an epidemic problem throughout the world. Relation of the diabetes with diet is known. Some evidence is reported about mother died and risk of diabetes in babies during the life related with gestational diabetes. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2ff2ecc5e69c85bc5a66a14eab7460
https://pubmed.ncbi.nlm.nih.gov/30537678
https://pubmed.ncbi.nlm.nih.gov/30537678