Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Gloyn, Al"'
Autor:
Thurner, M, Shenhav, L, Wesolowska-Andersen, A, Bennett, AJ, Barrett, A, Gloyn, AL, McCarthy, MI, Beer, NL, Efrat, S
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1395-1405 (2017)
Stem Cell Reports
Stem Cell Reports
Summary Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cell
Autor:
Carrat, GR, Hu, M, Nguyen-Tu, M-S, Chabosseau, P, Gaulton, KJ, van de Bunt, M, Siddiq, A, Falchi, M, Thurner, M, Canouil, M, Pattou, F, Leclerc, I, Pullen, TJ, Cane, MC, Prabhala, P, Greenwald, W, Schulte, A, Marchetti, P, Ibberson, M, MacDonald, PE, Manning Fox, JE, Gloyn, AL, Froguel, P, Solimena, M, McCarthy, M, Rutter, GA
Publikováno v:
American journal of human genetics, vol 100, iss 2
American journal of human genetics
Am. J. Hum. Genet. 100, 238-256 (2017)
Carrat, G R, Hu, M, Nguyen-Tu, M-S, Chabosseau, P, Gaulton, K J, van de Bunt, M, Siddiq, A, Falchi, M, Thurner, M, Canouil, M, Pattou, F, Leclerc, I, Pullen, T J, Cane, M C, Prabhala, P, Greenwald, W, Schulte, A, Marchetti, P, Ibberson, M, MacDonald, P E, Manning Fox, J E, Gloyn, A L, Froguel, P, Solimena, M, McCarthy, M I & Rutter, G A 2017, ' Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice ', American Journal of Human Genetics, vol. 100, no. 2, pp. 238-256 . https://doi.org/10.1016/j.ajhg.2017.01.011
American journal of human genetics
Am. J. Hum. Genet. 100, 238-256 (2017)
Carrat, G R, Hu, M, Nguyen-Tu, M-S, Chabosseau, P, Gaulton, K J, van de Bunt, M, Siddiq, A, Falchi, M, Thurner, M, Canouil, M, Pattou, F, Leclerc, I, Pullen, T J, Cane, M C, Prabhala, P, Greenwald, W, Schulte, A, Marchetti, P, Ibberson, M, MacDonald, P E, Manning Fox, J E, Gloyn, A L, Froguel, P, Solimena, M, McCarthy, M I & Rutter, G A 2017, ' Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice ', American Journal of Human Genetics, vol. 100, no. 2, pp. 238-256 . https://doi.org/10.1016/j.ajhg.2017.01.011
Genetic variants near ARAP1 (CENTD2) and STARD10 influence type 2 diabetes (T2D) risk. The risk alleles impair glucose-induced insulin secretion and, paradoxically but characteristically, are associated with decreased proinsulin:insulin ratios, indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2411d210afb9ad789dced93b5259a382
http://publikationen.ub.uni-frankfurt.de/files/33574/container.zip
http://publikationen.ub.uni-frankfurt.de/files/33574/container.zip
Autor:
Travers, ME, Mackay, DJ, Dekker Nitert, M, Morris, AP, Lindgren, CM, Berry, A, Johnson, PR, Hanley, N, Groop, LC, McCarthy, MI, Gloyn, AL
Publikováno v:
Diabetes
The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intro
Autor:
Suliman, SGI, Stanik, J, Misovicova, N, Gasperikova, D, Wilson, N, Edghill, E, Sandrikova, V, Elliot, K, Barak, L, Ellard, S, Volpi, E, Klimes, I, Gloyn, AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::96698c2808ed490ac8b1108a3d595fc4
https://ora.ox.ac.uk/objects/uuid:5877c244-b64a-4f93-b91b-77db66091003
https://ora.ox.ac.uk/objects/uuid:5877c244-b64a-4f93-b91b-77db66091003
Autor:
Rees, MG, Turner, C, Facio, FM, Beer, NL, McCarthy, MI, Biesecker, LG, Gloyn, AL, Collins, FS, Progra, NISCCS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f71ed1bc1e8a5483b6dfb0a6d642a74b
https://ora.ox.ac.uk/objects/uuid:c07c33ab-52f4-4c96-8a37-2b7b2057882e
https://ora.ox.ac.uk/objects/uuid:c07c33ab-52f4-4c96-8a37-2b7b2057882e
UNLABELLED: Glucokinase activators (GKAs) represent one of the leading hopes for the next generation of type 2 diabetes (T2D) therapeutics, showing efficacy in reducing blood glucose and HbA1c levels in animal models of T2D and short-term human trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bacac93d87f2d7bdf619407e7ca2ecfb
https://ora.ox.ac.uk/objects/uuid:ffb05e09-ac91-45a4-bf96-195523f4d84c
https://ora.ox.ac.uk/objects/uuid:ffb05e09-ac91-45a4-bf96-195523f4d84c