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Membrane-bound IL-6R is upregulated on Th17 cells and inhibits Treg cell migration by regulating post-translational modification of VASP in autoimmune arthritis.

Autor: Yan S; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany., Golumba-Nagy V; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany., Kotschenreuther K; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany., Thiele J; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany., Refaian N; Department of Ophthalmology, University of Cologne, Cologne, Germany., Shuya D; Department of Ophthalmology, University of Cologne, Cologne, Germany., Gloyer L; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany., Dittrich-Salamon M; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany., Meyer A; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany., Heindl LM; Department of Ophthalmology, University of Cologne, Cologne, Germany., Kofler DM; Laboratory of Molecular Immunology, Division of Rheumatology and Clinical Immunology, Department I of Internal Medicine, University of Cologne, Kerpenerstr. 62, 50937, Cologne, Germany. david.kofler@uk-koeln.de.; Center for Integrated Oncology, Aachen Bonn Cologne Duesseldorf, Cologne, Germany. david.kofler@uk-koeln.de.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Dec 16; Vol. 79 (1), pp. 3. Date of Electronic Publication: 2021 Dec 16.