Integration of rare expression outlier-associated variants improves polygenic risk prediction

Autor: Smail, Craig, Ferraro, Nicole M., Hui, Qin, Durrant, Matthew G., Aguirre, Matthew, Tanigawa, Yosuke, Keever-Keigher, Marissa R., Rao, Abhiram S., Justesen, Johanne M., Li, Xin, Gloudemans, Michael J., Assimes, Themistocles L., Kooperberg, Charles, Reiner, Alexander P., Huang, Jie, O'Donnell, Christopher J., Sun, Yan V., Rivas, Manuel A., Montgomery, Stephen B.

Publikováno v: In The American Journal of Human Genetics 2 June 2022 109(6):1055-1064

Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease

Autor: Anand, Shankara, Gabriel, Stacey, Getz, Gad A., Graubert, Aaron, Hadley, Kane, Handsaker, Robert E., Huang, Katherine H., Li, Xiao, MacArthur, Daniel G., Meier, Samuel R., Nedzel, Jared L., Nguyen, Duyen T., Segrè, Ayellet V., Todres, Ellen, Balliu, Brunilda, Bonazzola, Rodrigo, Brown, Andrew, Conrad, Donald F., Cotter, Daniel J., Cox, Nancy, Das, Sayantan, Dermitzakis, Emmanouil T., Einson, Jonah, Engelhardt, Barbara E., Eskin, Eleazar, Flynn, Elise D., Fresard, Laure, Gamazon, Eric R., Garrido-Martín, Diego, Gay, Nicole R., Guigó, Roderic, Hamel, Andrew R., He, Yuan, Hoffman, Paul J., Hormozdiari, Farhad, Hou, Lei, Jo, Brian, Kasela, Silva, Kashin, Seva, Kellis, Manolis, Kwong, Alan, Li, Xin, Liang, Yanyu, Mangul, Serghei, Mohammadi, Pejman, Muñoz-Aguirre, Manuel, Nobel, Andrew B., Oliva, Meritxell, Park, Yongjin, Parsana, Princy, Reverter, Ferran, Rouhana, John M., Sabatti, Chiara, Saha, Ashis, Stephens, Matthew, Stranger, Barbara E., Teran, Nicole A., Viñuela, Ana, Wang, Gao, Wright, Fred, Wucher, Valentin, Zou, Yuxin, Ferreira, Pedro G., Li, Gen, Melé, Marta, Yeger-Lotem, Esti, Bradbury, Debra, Krubit, Tanya, McLean, Jeffrey A., Qi, Liqun, Robinson, Karna, Roche, Nancy V., Smith, Anna M., Tabor, David E., Undale, Anita, Bridge, Jason, Brigham, Lori E., Foster, Barbara A., Gillard, Bryan M., Hasz, Richard, Hunter, Marcus, Johns, Christopher, Johnson, Mark, Karasik, Ellen, Kopen, Gene, Leinweber, William F., McDonald, Alisa, Moser, Michael T., Myer, Kevin, Ramsey, Kimberley D., Roe, Brian, Shad, Saboor, Thomas, Jeffrey A., Walters, Gary, Washington, Michael, Wheeler, Joseph, Jewell, Scott D., Rohrer, Daniel C., Valley, Dana R., Davis, David A., Mash, Deborah C., Barcus, Mary E., Branton, Philip A., Sobin, Leslie, Barker, Laura K., Gardiner, Heather M., Mosavel, Maghboeba, Siminoff, Laura A., Flicek, Paul, Haeussler, Maximilian, Juettemann, Thomas, Kent, W. James, Lee, Christopher M., Powell, Conner C., Rosenbloom, Kate R., Ruffier, Magali, Sheppard, Dan, Taylor, Kieron, Trevanion, Stephen J., Zerbino, Daniel R., Abell, Nathan S., Akey, Joshua, Chen, Lin, Demanelis, Kathryn, Doherty, Jennifer A., Feinberg, Andrew P., Hansen, Kasper D., Hickey, Peter F., Jasmine, Farzana, Jiang, Lihua, Kaul, Rajinder, Kibriya, Muhammad G., Li, Jin Billy, Li, Qin, Lin, Shin, Linder, Sandra E., Pierce, Brandon L., Rizzardi, Lindsay F., Skol, Andrew D., Smith, Kevin S., Snyder, Michael, Stamatoyannopoulos, John, Tang, Hua, Wang, Meng, Carithers, Latarsha J., Guan, Ping, Koester, Susan E., Little, A. Roger, Moore, Helen M., Nierras, Concepcion R., Rao, Abhi K., Vaught, Jimmie B., Volpi, Simona, de Goede, Olivia M., Nachun, Daniel C., Ferraro, Nicole M., Gloudemans, Michael J., Rao, Abhiram S., Smail, Craig, Eulalio, Tiffany Y., Aguet, François, Ng, Bernard, Xu, Jishu, Barbeira, Alvaro N., Castel, Stephane E., Kim-Hellmuth, Sarah, Park, YoSon, Scott, Alexandra J., Strober, Benjamin J., Brown, Christopher D., Wen, Xiaoquan, Hall, Ira M., Battle, Alexis, Lappalainen, Tuuli, Im, Hae Kyung, Ardlie, Kristin G., Mostafavi, Sara, Quertermous, Thomas, Kirkegaard, Karla, Montgomery, Stephen B.

Publikováno v: In Cell 13 May 2021 184(10):2633-2648

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

Autor: Liu, Boxiang, Pjanic, Milos, Wang, Ting, Nguyen, Trieu, Gloudemans, Michael, Rao, Abhiram, Castano, Victor G., Nurnberg, Sylvia, Rader, Daniel J., Elwyn, Susannah, Ingelsson, Erik, Montgomery, Stephen B., Miller, Clint L., Quertermous, Thomas

Publikováno v: In The American Journal of Human Genetics 6 September 2018 103(3):377-388

Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes.

Autor: Gloudemans, Michael J.^1,2 (AUTHOR) mgloud@stanford.edu, Balliu, Brunilda³ (AUTHOR), Nachun, Daniel^4,5 (AUTHOR), Schnurr, Theresia M.⁶ (AUTHOR), Durrant, Matthew G.⁴ (AUTHOR), Ingelsson, Erik⁶ (AUTHOR), Wabitsch, Martin⁷ (AUTHOR), Quertermous, Thomas^6,8 (AUTHOR), Montgomery, Stephen B.^2,4 (AUTHOR) smontgom@stanford.edu, Knowles, Joshua W.^6,8,9 (AUTHOR) knowlej@stanford.edu, Carcamo-Orive, Ivan^6,8 (AUTHOR) ivantxo@stanford.edu

Publikováno v: Genome Medicine. 3/15/2022, Vol. 14 Issue 1, p1-16. 16p.

Additional file 1 of Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes

Autor: Gloudemans, Michael J., Balliu, Brunilda, Nachun, Daniel, Schnurr, Theresia M., Durrant, Matthew G., Ingelsson, Erik, Wabitsch, Martin, Quertermous, Thomas, Montgomery, Stephen B., Knowles, Joshua W., Carcamo-Orive, Ivan

Additional file 1: Document containing supplementary Figures S1-S7 and supplementary Tables S1-S9. Fig. S1. Selection of genome-wide significant loci and overlapping eQTL/sQTL features for colocalization testing. Fig. S2. Example LocusCompare plots f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a5889b25b67bc3a8cf5734e3b44c7e