Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Gloriam DE"'
Autor:
Nøhr, AC, Shehata, MA, Hauser, AS, Isberg, V, Mokrosinski, J, Farooqi, IS, Pedersen, DS, Gloriam, DE, Bräuner-Osborne, H
GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is activated by the amino acids L-tryptophan and L-phenylalanine (EC50 val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::a67a17e20381d23a34e0eb44f788af47
https://www.repository.cam.ac.uk/handle/1810/266494
https://www.repository.cam.ac.uk/handle/1810/266494
Autor:
Shehata, MA, Belcik Christensen, H, Isberg, V, Sejer Pedersen, D, Bender, A, Bräuner-Osborne, H, Gloriam, DE
We report the first pharmacological tool agonist for in vitro characterization of the orphan receptor GPR132, preliminary structure–activity relationships based on 32 analogs and a suggested binding mode from docking.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::d737d126c36d8646ec2caed94f5ba9d2
https://www.repository.cam.ac.uk/handle/1810/248860
https://www.repository.cam.ac.uk/handle/1810/248860
Akademický článek
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Autor:
Nøhr, AC, Shehata, MA, Hauser, AS, Isberg, V, Mokrosinski, J, Farooqi, IS, Pedersen, DS, Gloriam, DE, Bräuner-Osborne, H
GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is activated by the amino acids L-tryptophan and L-phenylalanine (EC50 val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d007ad35777e687360b68f65c53ccf74
Autor:
Nøhr, AC, Shehata, MA, Hauser, AS, Isberg, V, Mokrosinski, J, Andersen, KB, Farooqi, IS, Pedersen, DS, Gloriam, DE, Bräuner-Osborne, H
GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is activated by the amino acids l-tryptophan and l-phenylalanine (EC50 val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec444b60e3b14867d43c854cda51140b
Autor:
Reiner-Link D; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Madsen JS; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Bräuner-Osborne H; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Hauser AS; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Publikováno v:
British journal of pharmacology [Br J Pharmacol] 2024 May 09. Date of Electronic Publication: 2024 May 09.
Autor:
Pándy-Szekeres G; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.; Medicinal Chemistry Research Group, HUN-REN Research Center for Natural Sciences, Budapest H-1117, Hungary., Taracena Herrera LP; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Caroli J; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Kermani AA; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Kulkarni Y; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark., Keserű GM; Medicinal Chemistry Research Group, HUN-REN Research Center for Natural Sciences, Budapest H-1117, Hungary., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark.
Publikováno v:
Nucleic acids research [Nucleic Acids Res] 2024 Jan 05; Vol. 52 (D1), pp. D466-D475.
Autor:
Simon IA; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Bjørn-Yoshimoto WE; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Harpsøe K; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Iliadis S; Centre for Endocrinology, William Harvey Research Institute, Bart's and the London School of Medicine and Dentistry, University of London, London EC1M 6BQ, UK., Svensson B; SARomics Biostructures AB, Scheelevägen 2, 223 63 Lund, Sweden., Jensen AA; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: david.gloriam@sund.ku.dk.
Publikováno v:
Trends in pharmacological sciences [Trends Pharmacol Sci] 2023 Dec; Vol. 44 (12), pp. 978-990. Date of Electronic Publication: 2023 Oct 31.
Autor:
Pottie E; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., Poulie CBM; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Simon IA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Harpsøe K; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., D'Andrea L; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Komarov IV; Enamine Ltd., Kyiv 02094, Ukraine., Gloriam DE; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Kristensen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark., Stove CP; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Campus Heymans, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.
Publikováno v:
ACS chemical neuroscience [ACS Chem Neurosci] 2023 Aug 02; Vol. 14 (15), pp. 2727-2742. Date of Electronic Publication: 2023 Jul 20.
Autor:
Grätz L; Karolinska Institutet, Dept. Physiology & Pharmacology, Sec. Receptor Biology & Signaling, Biomedicum, S-17165, Stockholm, Sweden., Kowalski-Jahn M; Karolinska Institutet, Dept. Physiology & Pharmacology, Sec. Receptor Biology & Signaling, Biomedicum, S-17165, Stockholm, Sweden., Scharf MM; Karolinska Institutet, Dept. Physiology & Pharmacology, Sec. Receptor Biology & Signaling, Biomedicum, S-17165, Stockholm, Sweden., Kozielewicz P; Karolinska Institutet, Dept. Physiology & Pharmacology, Sec. Receptor Biology & Signaling, Biomedicum, S-17165, Stockholm, Sweden., Jahn M; School of Engineering Sciences in Chemistry, Biotechnology and Health, Science for Life Laboratory, KTH - Royal Institute of Technology, S-17121, Solna, Sweden.; Max Planck Unit for the Science of Pathogens, Bioinformatics platform, Charitéplatz 1, D-10117, Berlin, Germany., Bous J; Karolinska Institutet, Dept. Physiology & Pharmacology, Sec. Receptor Biology & Signaling, Biomedicum, S-17165, Stockholm, Sweden., Lambert NA; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Schulte G; Karolinska Institutet, Dept. Physiology & Pharmacology, Sec. Receptor Biology & Signaling, Biomedicum, S-17165, Stockholm, Sweden. gunnar.schulte@ki.se.
Publikováno v:
Nature communications [Nat Commun] 2023 Jul 29; Vol. 14 (1), pp. 4573. Date of Electronic Publication: 2023 Jul 29.