Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gloria X Reyes"'
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype. Based on their findings, they propose that Mlh2/hPMS1-Mlh1 mutant complexes can act
Externí odkaz:
https://doaj.org/article/ca8b2b28c21f4262a1051bb3ba633b91
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Inactivating mutations affecting key mismatch repair (MMR) components lead to microsatellite instability (MSI) and cancer. However, a number of patients with MSI-tumors do not present alterations in classical MMR genes. Here we discovered that specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1bed393c7d33d1176ef4aa89473d21
https://doi.org/10.1038/s42003-020-01481-4
https://doi.org/10.1038/s42003-020-01481-4
Autor:
Sushma Sharma, Tobias T. Schmidt, Brian Luke, Anna Kolodziejczak, Tina Wagner, Andrei Chabes, Anders Hofer, Gloria X Reyes, Hans Hombauer
Publikováno v:
Nucleic Acids Research
The accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3957913e0d1f68da2d4f2bb7a1fa6f51
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170313
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170313
Autor:
Hans Hombauer, Maike Gross, Andrei Chabes, Sushma Sharma, Gloria X Reyes, Kerstin Gries, Jui-Hung Yuan, Rebecca C. Wade, Boyu Zhao, Tobias T. Schmidt
Publikováno v:
Nucleic Acids Research
The balance and the overall concentration of intracellular deoxyribonucleoside triphosphates (dNTPs) are important determinants of faithful DNA replication. Despite the established fact that changes in dNTP pools negatively influence DNA replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d592d25edb43717c08ca66aca1b16fa5
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154182
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154182
Autor:
Takashi Kubota, Lovely Jael Paul Solomon Devakumar, Hans Hombauer, Richard D. Kolodner, Gloria X Reyes, Anna Kolodziejczak, Christopher D. Putnam
Publikováno v:
Current biology : CB
Curr Biol
Curr Biol
SUMMARY Mismatch repair (MMR) safeguards genome stability through recognition and excision of DNA replication errors.1–4 How eukaryotic MMR targets the newly replicated strand in vivo has not been established. MMR reactions reconstituted in vitro a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14bbf0d194f1b6302d8f86a7144c965
http://europepmc.org/articles/PMC8281387
http://europepmc.org/articles/PMC8281387
Autor:
Cemile Ümran Ceylan, Hans Hombauer, Andrei Chabes, Kerstin Gries, Sushma Sharma, Gloria X Reyes, Michael Knop, Tobias T. Schmidt, Matthias Meurer
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Significance The duplication of the genetic information (DNA) requires high accuracy to prevent potentially deleterious genetic alterations (mutations). The fidelity of this reaction depends on DNA polymerase selectivity and proofreading functions, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0ea5870069ed05a38566567a0b1167
https://doi.org/10.1073/pnas.1618714114
https://doi.org/10.1073/pnas.1618714114