Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gloria S. Forkuo"'
Autor:
Gloria S. Forkuo, James M. Cook, Gene T. Yocum, Revathi Kodali, Leggy A. Arnold, Rajwana Jahan, Michael Rajesh Stephen, Margaret L. Guthrie, Douglas A. Steeber, Charles W. Emala, Douglas C. Stafford, Olivia B. Yu, Guanguan Li, Nicolas M Zahn, Ted William Harris, Janet L. Fisher, Amanda N. Nieman, M S Rashid Roni
Publikováno v:
Molecular Pharmaceutics. 15:1766-1777
We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α(5)β(3)γ(2) selective GABA(A) receptor (GABA(A)R) ligands. MIDD0301 relaxed airway smooth muscle at single micromolar concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b93345b08045b2b3af1122f8fda4a35
https://doi.org/10.1021/acs.molpharmaceut.7b01013
https://doi.org/10.1021/acs.molpharmaceut.7b01013
Autor:
Michael M. Poe, James M. Cook, Douglas C. Stafford, Leggy A. Arnold, Amanda N. Nieman, Nicolas M Zahn, Michael Rajesh Stephen, Ted William Harris, Guanguan Li, Revathi Kodali, Gene T. Yocum, Rajwana Jahan, Charles W. Emala, Benjamin D. Hartzler, Olivia B. Yu, Margaret L. Guthrie, Nina Y. Yuan, Douglas A. Steeber, Gloria S. Forkuo
Publikováno v:
Molecular Pharmaceutics. 14:2088-2098
We describe pharmacokinetic and pharmacodynamic properties of two novel oral drug candidates for asthma. Phenolic α4β3γ2 GABAAR selective compound 1 and acidic α5β3γ2 selective GABAAR positive allosteric modulator compound 2 relaxed airway smoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5755a9d9e97f0233975c5000c7783d33
https://doi.org/10.1021/acs.molpharmaceut.7b00183
https://doi.org/10.1021/acs.molpharmaceut.7b00183
Autor:
Margaret L. Guthrie, Nicolas M Zahn, Douglas C. Stafford, Rajwana Jahan, Leggy A. Arnold, James M. Cook, Charles W. Emala, Revathi Kodali, Olivia B. Yu, Nina Y. Yuan, Guanguan Li, Michael Rajesh Stephen, Gloria S. Forkuo, Gene T. Yocum, Michael M. Poe, Amanda N. Nieman
Publikováno v:
European Journal of Medicinal Chemistry. 126:550-560
We describe the synthesis of analogs of XHE-III-74, a selective α4β3γ2 GABAAR ligand, shown to relax airway smooth muscle ex vivo and reduce airway hyperresponsiveness in a murine asthma model. To improve properties of this compound as an asthma t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958734587f761ff39658058590c3aeda
https://doi.org/10.1016/j.ejmech.2016.11.045
https://doi.org/10.1016/j.ejmech.2016.11.045
Autor:
Michael M. Poe, Revathi Kodali, Gene T. Yocum, Margaret L. Guthrie, Marco Treven, Charles W. Emala, Benjamin D. Hartzler, Rajwana Jahan, Olivia B. Yu, Leggy A. Arnold, Guanguan Li, Michael Rajesh Stephen, James M. Cook, Nina Y. Yuan, Douglas C. Stafford, Gloria S. Forkuo, Nicolas M Zahn, Amanda N. Nieman, Margot Ernst
Publikováno v:
Molecular Pharmaceutics. 13:2026-2038
Recent studies have demonstrated that subtype-selective GABAA receptor modulators are able to relax precontracted human airway smooth muscle ex vivo and reduce airway hyper-responsiveness in mice upon aerosol administration. Our goal in this study wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cbadcb7c8bc5474f1d60762fc0c8f7
https://doi.org/10.1021/acs.molpharmaceut.6b00159
https://doi.org/10.1021/acs.molpharmaceut.6b00159
Autor:
Wayne Stallaert, Michel Bouvier, Vaidehi J. Thanawala, Richard A. Bond, Paul Leff, Gloria S. Forkuo
Publikováno v:
Current Opinion in Pharmacology. 16:50-57
β-blockers are used for a wide range of diseases from hypertension to glaucoma. In some diseases/conditions all β-blockers are effective, while in others only certain subgroups are therapeutically beneficial. The best-documented example for only a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125a6fa1678de0bd0764185d5471fbe5
https://doi.org/10.1016/j.coph.2014.03.002
https://doi.org/10.1016/j.coph.2014.03.002
Autor:
Gloria S. Forkuo, Amanda N. Nieman, Revathi Kodali, Nicolas M. Zahn, Guanguan Li, M. S. Rashid Roni, Michael Rajesh Stephen, Ted W. Harris, Rajwana Jahan, Margaret L. Guthrie, Olivia B. Yu, Janet L. Fisher, Gene T. Yocum, Charles W. Emala, Douglas A. Steeber, Douglas C. Stafford, James M. Cook, Leggy A. Arnold
Publikováno v:
Molecular Pharmaceutics. 16:4756-4756
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c76d467dd07547ff70186ecda308253
https://doi.org/10.1021/acs.molpharmaceut.9b01053
https://doi.org/10.1021/acs.molpharmaceut.9b01053
Autor:
Tonio Pera, Patricia Gonnella, Radhika Joshi, Gloria S. Forkuo, Brian J. Knoll, Sergio Parra, Hosu Kim, Vaidehi J. Thanawala, Raymond B. Penn, Daniel Valdez, Nour A. Al-Sawalha, Richard A. Bond, Julia K. L. Walker
Mice lacking the endogenous β2-adrenoceptor (β2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e9a4932f7d2cff6c9abd872692aac2
https://europepmc.org/articles/PMC4979368/
https://europepmc.org/articles/PMC4979368/
Autor:
Amanda N. Nieman, Gloria S. Forkuo, Nicolas Zahn, Revathi Kodali, Guanguan Li, M.S. Rashid Roni, Michael Rajesh Stephen, Ted Harris, Rajwana Jahan, Margaret Guthrie, Olivia Yu, Janet Fisher, Gene Yocum, Charles Emala, Douglas A. Steeber, Douglas C. Stafford, James Cook, Leggy A. Arnold
Publikováno v:
The Journal of Immunology. 200:44.11-44.11
MIDD0301 is a new lead compound designed for the oral treatment of asthma. It was developed from previously described α5β3γ2 selective GABAA receptor (GABAAR) modulators. MIDD0301 showed significant relaxation of Substance P contracted guinea pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6626ef6738cd797999b602e9a075a52
https://doi.org/10.4049/jimmunol.200.supp.44.11
https://doi.org/10.4049/jimmunol.200.supp.44.11
Autor:
Gloria S. Forkuo, Charles W. Emala, Gene T. Yocum, Oliva Yu, Mitchell H. Grayson, Margaret L. Guthrie, Douglas C. Stafford, Revathi Kodali, Amanda N. Nieman, Michael Rajesh Stephen, Leggy A. Arnold, James M. Cook
Publikováno v:
Journal of Allergy and Clinical Immunology. 141:AB81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d47651b2da19a58f496e40489afe89
https://doi.org/10.1016/j.jaci.2017.12.261
https://doi.org/10.1016/j.jaci.2017.12.261
Autor:
Rajwana Jahan, Revathi Kodali, Mitchell H. Grayson, Charles W. Emala, Olivia B. Yu, Gloria S. Forkuo, Gene T. Yocum, Margaret L. Guthrie, Michael S. Stephen, Amanda N. Nieman, Nina Yuan, Leggy A. Arnold, James M. Cook
Publikováno v:
Journal of Allergy and Clinical Immunology. 139:AB9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5fc7ef50e10cea776ec6fb1726f71d
https://doi.org/10.1016/j.jaci.2016.12.083
https://doi.org/10.1016/j.jaci.2016.12.083