Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gloria Pedot"'
Autor:
Vadim Saratov, Quy A. Ngo, Gloria Pedot, Semjon Sidorov, Marco Wachtel, Felix K. Niggli, Beat W. Schäfer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract As the second most common pediatric bone and soft tissue tumor, Ewing sarcoma (ES) is an aggressive disease with a pathognomonic chromosomal translocation t(11;22) resulting in expression of EWS-FLI1, an “undruggable” fusion protein acti
Externí odkaz:
https://doaj.org/article/a89a844999154563b8c8a1db91001c39
Autor:
Gloria Pedot, Joana Graça Marques, Philip P. Ambühl, Marco Wachtel, Stephanie Kasper, Quy A. Ngo, Felix K. Niggli, Beat W. Schäfer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 31, Iss , Pp 100805- (2022)
Externí odkaz:
https://doaj.org/article/2eafa1ce24fd4896a86e7d22a2679327
Autor:
Lisa Bierbaumer, Anna M. Katschnig, Branka Radic-Sarikas, Maximilian O. Kauer, Jeffrey A. Petro, Sandra Högler, Elisabeth Gurnhofer, Gloria Pedot, Beat W. Schäfer, Raphaela Schwentner, Karin Mühlbacher, Florian Kromp, Dave N. T. Aryee, Lukas Kenner, Aykut Uren, Heinrich Kovar
Publikováno v:
Oncogenesis, Vol 10, Iss 1, Pp 1-13 (2021)
Abstract Ewing sarcoma (EwS) is a highly metastatic bone cancer characterized by the ETS fusion oncoprotein EWS-FLI1. EwS cells are phenotypically highly plastic and switch between functionally distinct cell states dependent on EWS-FLI1 fluctuations.
Externí odkaz:
https://doaj.org/article/89a3d3215d074d5aa6480f4b4cd974c1
Autor:
Gloria Pedot, Joana Graça Marques, Philip P. Ambühl, Marco Wachtel, Stephanie Kasper, Quy A. Ngo, Felix K. Niggli, Beat W. Schäfer
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 27, Iss , Pp 100784- (2022)
Oncogenic transcription factors lacking enzymatic activity or targetable binding pockets are typically considered “undruggable”. An example is provided by the EWS-FLI1 oncoprotein, whose continuous expression and activity as transcription factor
Externí odkaz:
https://doaj.org/article/f24c79f3904c4ff989ef5f1f94d4e53d
Autor:
Maria E. Gierisch, Gloria Pedot, Franziska Walser, Laura A. Lopez-Garcia, Patricia Jaaks, Felix K. Niggli, Beat W. Schäfer
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Ewing sarcoma is the second most common pediatric bone and soft tissue tumor presenting with an aggressive behavior and prevalence to metastasize. The diagnostic translocation t(22;11)(q24;12) leads to expression of the chimeric oncoprotein
Externí odkaz:
https://doaj.org/article/a3adb4d3106e433a8db0de295f5c3477
Autor:
Vadim Saratov, Quy A. Ngo, Gloria Pedot, Semjon Sidorov, Marco Wachtel, Felix K. Niggli, Beat W. Schäfer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/e15d247bc5b94603a306e083c69fd581
Autor:
Martin Pruschy, Beat Schäfer, Gloria Pedot, Marco Wachtel, Irma Telarovic, Ashish Sharma, Fabienne Tschanz, Tamara Kazimova
Supplementary Data supporting results of main manuscript; with other cell lines; with control experiments; includes data table Figure S1. PlGF secretion is increased in multiple cell lines after irradiation. Figure S2. PlGF mRNA expression is increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da7756629666d48a24f9b2500c17050
https://doi.org/10.1158/1541-7786.22526540.v1
https://doi.org/10.1158/1541-7786.22526540.v1
Autor:
Martin Pruschy, Beat Schäfer, Gloria Pedot, Marco Wachtel, Irma Telarovic, Ashish Sharma, Fabienne Tschanz, Tamara Kazimova
Placental growth factor (PlGF) is a pro-angiogenic, N-glycosylated growth factor, which is secreted under pathologic situations. Here, we investigated the regulation of PlGF in response to ionizing radiation (IR) and its role for tumor angiogenesis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3fa445adf983cd8cc7750ef16c14df
https://doi.org/10.1158/1541-7786.c.6545129.v1
https://doi.org/10.1158/1541-7786.c.6545129.v1
Autor:
Joana Graca Marques, Blaz Pavlovic, Quy Ai Ngo, Gloria Pedot, Michaela Roemmele, Larissa Volken, Marco Wachtel, Beat W. Schäfer
Publikováno v:
Clinical Cancer Research. 28:B010-B010
Ewing sarcoma tumorigenesis is tightly linked to epigenetic deregulation. Indeed, the aberrant fusion transcription factor and tumor driver EWS-FLI1 produces extensive rewiring of the cancer cell epigenome. At enhancers containing canonical ETS motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166055b5ac6d606613198e9309c74dff
https://doi.org/10.1158/1557-3265.sarcomas22-b010
https://doi.org/10.1158/1557-3265.sarcomas22-b010
Autor:
Gloria Pedot, Joana Graça Marques, Philip P. Ambühl, Marco Wachtel, Stephanie Kasper, Quy A. Ngo, Felix K. Niggli, Beat W. Schäfer
Publikováno v:
Neoplasia. 31:100805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::474a39565d19b7960cec6be40c16df80
https://doi.org/10.1016/j.neo.2022.100805
https://doi.org/10.1016/j.neo.2022.100805