Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Gloria Menchi"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 200-211 (2020)
The Cu-catalyzed multicomponent ketone–amine–alkyne (KA2) reaction was combined with a Pauson–Khand cycloaddition to give access of unprecedented constrained spirocyclic pyrrolocyclopentenone derivatives following a DOS couple-pair approach. Th
Externí odkaz:
https://doaj.org/article/0aa7afa4c3e1487491a29a93936e3d22
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Diversity-Oriented Synthesis (DOS) consists of generating structurally diverse compounds from a complexity-generating reaction followed by cyclization steps and appendage diversity. DOS has gathered interest to systematically explore the chemical spa
Externí odkaz:
https://doaj.org/article/77f07262dea644a6ab54dba2e1eba7c3
Autor:
Elena Lenci, Irene Stefanini, Antonio Guarna, Gloria Menchi, Duccio Cavalieri, Andrea Trabocchi
Publikováno v:
Proceedings, Vol 1, Iss 6, p 678 (2017)
Modern advances in Chemical Biology include the improvement of screening methods, the introduction of bioinformatic methods to unravel biological pathways, and the generation of highquality chemical libraries. [...]
Externí odkaz:
https://doaj.org/article/609aa7d2eb3a44a99bb576d0c6ab3ed9
Autor:
Elena Lenci, Riccardo Innocenti, Alessio Biagioni, Gloria Menchi, Francesca Bianchini, Andrea Trabocchi
Publikováno v:
Molecules, Vol 21, Iss 10, p 1405 (2016)
The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis
Externí odkaz:
https://doaj.org/article/62f8607118f64b8dbe866dd352506979
Autor:
Elena Lenci, Cristina Faggi, Andrea Trabocchi, Gloria Menchi, Riccardo Innocenti, Lorenzo Baldini
Publikováno v:
European Journal of Organic Chemistry. 2019:6203-6210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a90e27d2c091804776dbcc28cbd04e
https://doi.org/10.1002/ejoc.201900703
https://doi.org/10.1002/ejoc.201900703
Autor:
Fernanda I. Saldívar-González, José L. Medina-Franco, Elena Lenci, Andrea Trabocchi, Gloria Menchi
Publikováno v:
Organic & Biomolecular Chemistry. 17:1037-1052
Natural products (NPs) have been shown to be an extraordinary source of bioactive compounds and three-dimensional complex frameworks that can be useful to produce high-value molecular collections that are able to address "undruggable" and difficult t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f6270b37ec701968174b28706e9ec
https://doi.org/10.1039/c8ob02808g
https://doi.org/10.1039/c8ob02808g
Publikováno v:
Synlett. 29:820-824
The application of iminium catalysis to the challenging Morita–Baylis–Hillman reaction on cyclopenten-2-one leads to the corresponding allylic alcohols in excellent yields. Experimental evidence shows that secondary amines act as co-catalysts act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab23a1355016de377eab865c44baa0ec
https://doi.org/10.1055/s-0036-1591521
https://doi.org/10.1055/s-0036-1591521
Publikováno v:
Organic & Biomolecular Chemistry. 15:9710-9717
A convenient synthesis of novel complex morpholines was achieved by a two-step process involving a Petasis three-component coupling reaction of glycolaldehyde, organoboronic acid and different amines, followed by an acid- or base-mediated intramolecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f486f40ee200c217832a49eea7a65ae
https://doi.org/10.1039/c7ob02454a
https://doi.org/10.1039/c7ob02454a
Publikováno v:
Beilstein Journal of Organic Chemistry
The Cu-catalyzed multicomponent ketone–amine–alkyne (KA2) reaction was combined with a Pauson–Khand cycloaddition to give access of unprecedented constrained spirocyclic pyrrolocyclopentenone derivatives following a DOS couple-pair approach. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5f8e60fb246e6f24fa5166909aed4a9
https://pubmed.ncbi.nlm.nih.gov/32117477
https://pubmed.ncbi.nlm.nih.gov/32117477
Autor:
Riccardo Innocenti, Francesca Bianchini, Tommaso Di Francescantonio, Alessandro Contini, Elena Lenci, Gloria Menchi, Andrea Trabocchi
Publikováno v:
Bioorganicmedicinal chemistry. 27(9)
MMP2 and MMP9, also called gelatinases, play a primary role in the angiogenic switch, as a fundamental step of tumor progression, and show high degree of structural similarity. Clinically successful gelatinase inhibitors need to be highly selective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2bb0730dda43a4fc17786ebc2fc7fc
https://pubmed.ncbi.nlm.nih.gov/30926311
https://pubmed.ncbi.nlm.nih.gov/30926311