Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Gloria M. Culver"'
Publikováno v:
Biochimie
The bacterial ribosomal protein S15 is located in the platform, a functional region of the 30S ribosomal subunit. While S15 is critical for in vitro formation of E. coli small subunits (SSUs), it is dispensable for in vivo biogenesis and growth. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2716ae304caf0cfbf21e7f5040dd63df
https://doi.org/10.1016/j.biochi.2021.09.003
https://doi.org/10.1016/j.biochi.2021.09.003
Autor:
Anusha Naganathan, Gloria M. Culver
Publikováno v:
Annual review of microbiology. 76
The pace and efficiency of ribosomal subunit production directly impact the fitness of bacteria. Biogenesis demands more than just the union of ribosomal components, including RNA and proteins, to form this functional ribonucleoprotein particle. Extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7c891e4e1a0d43a7fa5c56175a21bb
https://pubmed.ncbi.nlm.nih.gov/35609945
https://pubmed.ncbi.nlm.nih.gov/35609945
Autor:
Gloria M. Culver, Nathan Napper
Publikováno v:
RNA. 21:1323-1334
The ribosome is a large macromolecular complex that must be assembled efficiently and accurately for the viability of all organisms. In bacteria, this process must be robust and tunable to support life in diverse conditions from the ice of arctic gla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660da6ec27998a80483c239f077ae671
https://doi.org/10.1261/rna.048918.114
https://doi.org/10.1261/rna.048918.114
Publikováno v:
Journal of molecular biology. 430(12)
Ribosomal RNA (rRNA) is a major component of ribosomes and is fundamental to the process of translation. In bacteria, 16S rRNA is a component of the small ribosomal subunit and plays a critical role in mRNA decoding. rRNA maturation entails the remov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc32e66ef43a765fd1019083570a3d7
https://pubmed.ncbi.nlm.nih.gov/29660326
https://pubmed.ncbi.nlm.nih.gov/29660326
Autor:
Gloria M. Culver, Neha Gupta
Publikováno v:
Nature structural & molecular biology
Processing of transcribed precursor ribosomal RNA (pre-rRNA) to a mature state is a conserved aspect of ribosome biogenesis in vivo. We developed an affinity-purification system to isolate and analyze in vivo-formed pre-rRNA-containing ribonucleoprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c83b2770e6dbb94c953e522458db2d
http://europepmc.org/articles/PMC4355579
http://europepmc.org/articles/PMC4355579
Autor:
Gloria M. Culver, Keith Connolly
Publikováno v:
Molecular Microbiology. 87:968-981
KsgA, a universally conserved small ribosomal subunit (SSU) rRNA methyltransferase, has recently been shown to facilitate a checkpoint within the ribosome maturation pathway. Under standard growth conditions removal of the KsgA checkpoint has a subtl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0013d6cc3bdf02208fa5be4e88afdea
https://doi.org/10.1111/mmi.12145
https://doi.org/10.1111/mmi.12145
Publikováno v:
Biochemistry. 50:854-863
KsgA is an rRNA methyltransferase important to the process of small subunit biogenesis in bacteria. It is ubiquitously found in all life including archaea and eukarya, where the enzyme is referred to as Dim1. Despite the emergence of considerable dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c816b1760307c2d5bb66a134e0f3d4
https://doi.org/10.1021/bi101005r
https://doi.org/10.1021/bi101005r
Autor:
Zhili Xu, Gloria M. Culver
Publikováno v:
RNA. 16:1990-2001
Rapid and accurate assembly of the ribosomal subunits, which are responsible for protein synthesis, is required to sustain cell growth. Our best understanding of the interaction of 30S ribosomal subunit components (16S ribosomal RNA [rRNA] and 20 rib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0ec3535bffbf3eda640c27a6a12575
https://doi.org/10.1261/rna.2246710
https://doi.org/10.1261/rna.2246710
Publikováno v:
Proceedings of the National Academy of Sciences. 107:4567-4572
Ribosomal protein S5 is critical for small ribosomal subunit (SSU) assembly and is indispensable for SSU function. Previously, we identified a point mutation in S5, (G28D) that alters both SSU formation and translational fidelity in vivo, which is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fd43958c43e4b4c3202981065ed51b
https://doi.org/10.1073/pnas.0912305107
https://doi.org/10.1073/pnas.0912305107
Autor:
Zhili Xu, Leah A. Pogorzala, Faik N. Musayev, Nagesh Pulicherla, Gloria M. Culver, Jason P. Rife, Heather C. O′Farrell, J. Neel Scarsdale, Elaine A. Sia
Publikováno v:
Journal of Molecular Biology. 391:884-893
The enzymes of the KsgA/Dim1 family are universally distributed throughout all phylogeny; however, structural and functional differences are known to exist. The well-characterized function of these enzymes is to dimethylate two adjacent adenosines of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714a0e8cae2793f4962d626824d417c0
https://doi.org/10.1016/j.jmb.2009.06.015
https://doi.org/10.1016/j.jmb.2009.06.015