Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Gloria Lau"'
Autor:
Pamela J. Laird, Roz Walker, Gabrielle McCallum, Maree Toombs, Melanie Barwick, Peter Morris, Robyn Aitken, Matthew Cooper, Richard Norman, Bhavini Patel, Gloria Lau, Anne B. Chang, André Schultz
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background In children, chronic wet cough may be a sign of underlying lung disease, including protracted bacterial bronchitis (PBB) and bronchiectasis. Chronic (> 4 weeks in duration) wet cough (without indicators pointing to alternative cau
Externí odkaz:
https://doaj.org/article/1ef507bf43434efaac16c692dcebaffe
Autor:
Pamela Laird, Nicola Ball, Shekira Brahim, Henry Brown, Anne B. Chang, Matthew Cooper, Deanne Cox, Denetta Cox, Samantha Crute, Rachel E. Foong, Janella Isaacs, John Jacky, Gloria Lau, Elizabeth McKinnon, Annie Scanlon, Elizabeth F. Smith, Sarah Thomason, Roz Walker, André Schultz
Publikováno v:
Pediatric pulmonologyREFERENCES. 57(12)
The burden of bronchiectasis is disproportionately high in Aboriginal adults, with early mortality. Bronchiectasis precursors, that is, protracted bacterial bronchitis (PBB) and chronic suppurative lung disease (CSLD), often commence in early childho
Autor:
Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C. Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor Tybulewicz, Elizabeth M.C. Fisher, Frances K. Wiseman
Individuals who have Down syndrome frequently develop early onset Alzheimer’s disease, a neurodegenerative condition caused by the build-up of aggregated amyloid-β and tau proteins in the brain. Amyloid-β is produced by APP, a gene located on chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6896141e197f81cafe6634791d35da
https://doi.org/10.1101/2022.03.10.483782
https://doi.org/10.1101/2022.03.10.483782
Autor:
Gloria Lau Chang
Publikováno v:
Aula y Ciencia. 8:203-238
El propósito de esta investigación es establecer una correlación entre los valores motivacionales y la cultura de paz en los estudiantes del Programa de Estudios Básicos de la Universidad Ricardo Palma 2013, en el marco conceptual del desarrollo
Publikováno v:
Psychiatria Danubina. 31(Suppl 3)
Anxiety and depression contribute to a substantial burden of Chronic Obstructive Pulmonary Disease-related morbidity by impairing quality of life and by reducing adherence to treatment. The identification of COPD patients with comorbid depression or
Publikováno v:
Psychiatria Danubina. 31(Suppl 3)
Schizophrenic patients have traditionally suffered from high rates of cardiovascular disease and early mortality. NICE guidelines suggest that several physical health measures be monitored regularly in these patients, and particularly those on antips
Publikováno v:
Journal of Biological Chemistry. 290:11041-11051
The chemokine receptors CCR5 and CCR2b share 89% amino acid homology. CCR5 is a co-receptor for HIV and CCR5 antagonists have been investigated as inhibitors of HIV infection. We describe the use of two CCR5 antagonists, Schering-C (SCH-C), which is
Autor:
Dana Huskens, Marilyn C. Darkes, Gary Bridger, Jennifer H. Cox, Simon P. Fricker, Zefferino Santucci, Renee Mosi, Jean Labrecque, Kim L. Nelson, Renato Skerlj, Stefan R. Idzan, Virginia Anastassova, Dominique Schols, Ketan Patel, Rebecca S.Y. Wong, Gloria Lau
Publikováno v:
Biochemical Pharmacology. 83:472-479
In order to enter and infect human cells HIV must bind to CD4 in addition to either the CXCR4 or the CCR5 chemokine receptor. AMD11070 was the first orally available small molecule antagonist of CXCR4 to enter the clinic. Herein we report the molecul
Autor:
Zefferino Santucci, Gary Bridger, Gloria Lau, Dominique Schols, Elyse Bourque, Wen Yang, Simon P. Fricker, Markus Metz, Curtis Harwig, Marilyn C. Darkes, Renato T. Skerlj, Jonathan Langille, Jean Labrecque, Sanjay Danthi
Publikováno v:
Journal of the American Chemical Society. 133:16477-16485
The viral resistance of marketed antiviral drugs including the emergence of new viral resistance of the only marketed CCR5 entry inhibitor, maraviroc, makes it necessary to develop new CCR5 allosteric inhibitors. A mutagenesis/modeling approach was u
Autor:
Tong-Shuang Li, Simon P. Fricker, Gang Chen, Renato Skerlj, David Bogucki, Markus Metz, Gary Bridger, Susan Nan, Rebecca S.Y. Wong, Dominique Schols, Jean Labrecque, Gloria Lau, Marilyn C. Darkes, Bryon Carpenter
Publikováno v:
Virology. 413(2):231-243
Based on the attrition rate of CCR5 small molecule antagonists in the clinic the discovery and development of next generation antagonists with an improved pharmacology and safety profile is necessary. Herein, we describe a combined molecular modeling