Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gloria J. Klapstein"'
Publikováno v:
Inflammopharmacology. 20:109-126
It has become increasingly clear that inflammatory processes play a significant role in the pathophysiology of Alzheimer's disease (AD). Neuroinflammation is characterized by the activation of astrocytes and microglia and the release of proinflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b41d61195d0ce86c5fefe91a352a6bd
https://doi.org/10.1007/s10787-012-0130-z
https://doi.org/10.1007/s10787-012-0130-z
Autor:
Oanh Kieu Nguyen, Gloria J. Klapstein, Nan Ping Wu, Véronique M. André, Harry V. Vinters, Susan Koh, Jorge Flores-Hernandez, Michael Levine, Carlos Cepeda, Snow T. Nguyen, Gary W. Mathern
Publikováno v:
Developmental Neuroscience. 27:59-76
Seizures in cortical dysplasia (CD) could be from cytomegalic neurons and balloon cells acting as epileptic ‘pacemakers’, or abnormal neurotransmission. This study examined these hypotheses using in vitro electrophysiological techniques to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bfdd43327cf0eaa675ab661e2769c3
https://doi.org/10.1159/000084533
https://doi.org/10.1159/000084533
Autor:
Oanh Kieu Nguyen, Jorge Flores-Hernandez, Carlos Cepeda, Gary W. Mathern, Emily L. Jocoy, Raymond S. Hurst, Michael Levine, Harry V. Vinters, Elizabeth Hernández-Echeagaray, Gloria J. Klapstein, M.K. Boylan, Christopher R. Calvert, Véronique M. André, Marjorie A. Ariano
Publikováno v:
Journal of Neuroscience Research. 72:472-486
The mechanisms responsible for seizure generation in cortical dysplasia (CD) are unknown, but morphologically abnormal cells could contribute. We examined the passive and active membrane properties of cells from pediatric CD in vitro. Normal- and abn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fdc5baceacc12df96a09323a43dee73
https://doi.org/10.1002/jnr.10604
https://doi.org/10.1002/jnr.10604
Autor:
E S Jokel, Kathryn Chase, Carlos Cepeda, Frederick M. Boyce, B A Cadigan, L Warzecki, Michael Levine, C McIntyre, Neil Aronin, Gloria J. Klapstein, M Campbell, Genevieve A. Laforet, P. H. Reddy, C R Calvert, Marian DiFiglia, D A Tagle, M. A. Ariano, E Sapp
Publikováno v:
The Journal of Neuroscience. 21:9112-9123
Neurons in Huntington's disease exhibit selective morphological and subcellular alterations in the striatum and cortex. The link between these neuronal changes and behavioral abnormalities is unclear. We investigated relationships between essential n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a82cad50b526e8beae5eb42f51b68b6
https://doi.org/10.1523/jneurosci.21-23-09112.2001
https://doi.org/10.1523/jneurosci.21-23-09112.2001
Autor:
Raymond S. Hurst, Scott Zeitlin, Hadi Shojaeian Zanjani, Carlos Cepeda, Michael Levine, Eve S. Jokel, Ellen M. Carpenter, Mauricio E. Vargas, Ahrin Koppel, Marie-Françoise Chesselet, Ehud Gruen, Argiris Efstratiadis, Gloria J. Klapstein
Publikováno v:
Journal of Neuroscience Research. 58:515-532
We used two mouse models of Huntington's disease (HD) to examine changes in glutamate receptor sensitivity and striatal electrophysiology. One model, a transgenic, consisted of mice expressing exon 1 of the human HD gene and carrying 141–157 CAG re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46bc752108b5ecd9c92acc1c15c72eaa
https://doi.org/10.1002/(sici)1097-4547(19991115)58:4<515::aid-jnr5>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19991115)58:4<515::aid-jnr5>3.0.co
Publikováno v:
Neuropharmacology. 38:927-933
The ability of the selective Group III mGluR agonist L-serine-O-phosphate (L-SOP) to inhibit lateral perforant path (LPP) evoked responses in the dentate gyrus was tested in hippocampal slices from commissurally-kindled rats 1-2 days after the last s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ace752f8bfcd3e69451fcfc8355c3e0
https://doi.org/10.1016/s0028-3908(99)00016-7
https://doi.org/10.1016/s0028-3908(99)00016-7
Publikováno v:
Journal of Neurophysiology. 78:1651-1661
Klapstein, Gloria J. and William F. Colmers. Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro. J. Neurophysiol. 78: 1651–1661, 1997. Neuropeptide Y (NPY) potently inhibits glutamate-mediated synaptic transmission in areas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c69f1e20c94b2b5ed6a0e7a987422f
https://doi.org/10.1152/jn.1997.78.3.1651
https://doi.org/10.1152/jn.1997.78.3.1651
Autor:
Jorge Flores-Hernandez, Marian DiFiglia, Christopher R. Calvert, Carlos Cepeda, Scott H. Chandler, Elizabeth Hernández-Echeagaray, Neil Aronin, Michael Levine, Gloria J. Klapstein, Marjorie A. Ariano
Publikováno v:
Journal of neurophysiology. 93(5)
Huntington's disease (HD) is a neurodegenerative disorder that mainly affects the projection neurons of the striatum and cerebral cortex. Genetic mouse models of HD have shown that neurons susceptible to the mutation exhibit morphological and electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aca05c1cb89e1307fa3c390f4a5f94c
https://pubmed.ncbi.nlm.nih.gov/15625098
https://pubmed.ncbi.nlm.nih.gov/15625098
Autor:
Gloria J. Klapstein, Michael Levine
Publikováno v:
Journal of neurophysiology. 93(2)
We used the oxygen/glucose deprivation (OGD) model of ischemia in corticostriatal brain slices to test the hypothesis that metabolic deficiencies in R6/2 transgenic Huntington's disease (HD) mice will impair their recovery from an ischemic challenge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91182c62f803665b2dd3880338e0c638
https://pubmed.ncbi.nlm.nih.gov/15371492
https://pubmed.ncbi.nlm.nih.gov/15371492
Autor:
Nigel T. Maidment, Mahadevan Gajendiran, Marie-Françoise Chesselet, Jie Shen, Matthew S. Goldberg, Sheila M. Fleming, Anushree Bhatnagar, Larry C. Ackerson, Gloria J. Klapstein, Edward G. Meloni, Michael Levine, Carlos Cepeda, Bryan L. Roth, James Palacino, Nanping Wu, Hoa A. Lam
Publikováno v:
The Journal of biological chemistry. 278(44)
Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease. To investigate the pathogenic mechanism by which loss of parkin function causes Parkinson's disease, we generated a mouse model bearing a germline d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca82f149704b8f2cc73bdac3799c27e1
https://pubmed.ncbi.nlm.nih.gov/12930822
https://pubmed.ncbi.nlm.nih.gov/12930822