Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gloria D Jahnke"'
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Autor:
Douglas A. Keller, Arianna Bassan, Alexander Amberg, Leigh Ann Burns Naas, Jon Chambers, Kevin Cross, Frances Hall, Gloria D. Jahnke, Amarjit Luniwal, Serena Manganelli, Jordi Mestres, Amy L. Mihalchik-Burhans, David Woolley, Raymond R. Tice
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
In silico toxicology protocols are meant to support computationally-based assessments using principles that ensure that results can be generated, recorded, communicated, archived, and then evaluated in a uniform, consistent, and reproducible manner.
Externí odkaz:
https://doaj.org/article/662e50fa83754807891531c6e030ecd7
Publikováno v:
J Natl Cancer Inst
The National Toxicology Program strives to raise awareness of cancer hazards in our environment. Identifying cancer hazards is key to primary prevention, informing public health decision making, and decreasing the global cancer burden. In December 20
Autor:
Frank Bringezu, Phillip Bellion, Alexander Amberg, Jeffrey M. Birmingham, Alejandra Trejo-Martin, Glenn J. Myatt, Amy L. Mihalchik-Burhans, Amarjit Luniwal, Naomi L. Kruhlak, Rosalie K. Elespuru, Karen H. Watanabe-Sailor, Louise Neilson, Lidia Ceriani, Markus Frericks, Alessandro Brigo, John P. Rooney, Arun R. Pandiri, Helga Gerets, Alice Luu, Arianna Bassan, Angela White, Marc A. Beal, Federica Madia, Manuela Pavan, David Faulkner, Lennart T. Anger, Elena Lo Piparo, Marie C. Fortin, Jordi Mestres, Ian Crooks, David Woolley, Raymond R. Tice, Paul Fowler, Balasubramanian Manickam, David R. Jones, Cynthia V. Rider, Serena Manganelli, Juan Lopez-Belmonte, Gloria D. Jahnke, Kevin P. Cross, Romualdo Benigni
Publikováno v:
Comput Toxicol
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which require enormous resources in both money and time. In silico models have been developed for predicting rodent carcinogens but have not yet found general reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de085dd3094d276c69682e6dfe5bb402
https://europepmc.org/articles/PMC8967183/
https://europepmc.org/articles/PMC8967183/
Publikováno v:
Environmental Health Perspectives
Background: Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic d
Autor:
Ruth M. Lunn, Dana Loomis, Andrew J. Shapiro, Neela Guha, Pamela J. Schwingl, Suril S. Mehta, Sebastien Antoni, Kathryn Z. Guyton, Josh Addington, Ivan Rusyn, Gloria D. Jahnke
Publikováno v:
Environmental Health Perspectives
Summary: Objective and systematic methods to search, review, and synthesize published studies are a fundamental aspect of carcinogen hazard classification. Systematic review is a historical strength of the International Agency for Research on Cancer
A viral etiology of cancer was first demonstrated in 1911 by Peyton Rous who injected cell-free filtrate from a chicken sarcoma into healthy chickens and found it induced a tumour. Since the discovery over 50 years ago of the Epstein-Barr virus as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4872c94e10d272bb6095e1b50ba19095
https://europepmc.org/articles/PMC5597733/
https://europepmc.org/articles/PMC5597733/
Autor:
Rebecca L. Morgan, Juleen Lam, Glinda S. Cooper, Andrew D. Kraft, Jennifer M. Ratcliffe, Kristina A. Thayer, Andrew A. Rooney, Holger J. Schünemann, Gloria D. Jahnke, Abee L. Boyles, Teneille Walker, Pamela J. Schwingl, Ruth M. Lunn
Publikováno v:
Environment International, Vol 92, Iss, Pp 617-629 (2016)
Environmental health hazard assessments are routinely relied upon for public health decision-making. The evidence base used in these assessments is typically developed from a collection of diverse sources of information of varying quality. It is crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5adf0ddc5e39c0911f372263cb8fbb3
https://europepmc.org/articles/PMC4902751/
https://europepmc.org/articles/PMC4902751/
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 94:677-682
Iodine deficiency is an important nutritional deficiency, with more than 2 billion people worldwide estimated to be at risk. The developing fetus and young children are particularly at risk. During pregnancy and lactation, iodine requirements increas
Autor:
Christina B. Myers, Rick Williams, Melissa C. Marr, Gayle Bieler, Catherine J. Price, Julia D. George, Gloria D. Jahnke
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 77:207-215
BACKGROUND: In pregnant women, antiretroviral drugs improve maternal health and reduce vertical transmission of human immunodeficiency virus to the infant. However, few nonclinical studies have examined the potential for adverse drug interactions. ME