Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gloria Ceballos-Pérez"'
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background Trypanosomes are single-celled eukaryotes that rely heavily on post-transcriptional mechanisms to regulate gene expression. RNA-binding proteins play essential roles in regulating the fate, abundance and translation of messenger R
Externí odkaz:
https://doaj.org/article/c5c124e01738450b95f6fbd948d60125
Autor:
Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Veronica Gomez-Pérez, Luis Miguel Ruiz-Pérez, Domingo I Rojas-Barros, Francisco Gamarro, Dolores González-Pacanowska, María S Martínez-Martínez, Pilar Manzano, Lori Ferrins, Conor R Caffrey, Miguel Navarro, Michael P Pollastri
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007129 (2019)
New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase
Externí odkaz:
https://doaj.org/article/8cc5ddaa83b043e2aaad8dbc1ec31ea7
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 660-670 (2016)
During infection in mammals, the protozoan parasite Trypanosoma brucei transforms from a proliferative bloodstream form to a quiescent form that is pre-adapted to host transition. AMP analogs are known to induce quiescence and also inhibit TbTOR4. To
Externí odkaz:
https://doaj.org/article/75340ac5c06a44988442762d1be1b62d
Autor:
Diana Carranza, Sara Torres-Rusillo, Gloria Ceballos-Pérez, Eva Blanco-Jimenez, Martin Muñoz-López, José L. García-Pérez, Ignacio J. Molina
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Ataxia-telangiectasia (A-T) is a complex disease arising from mutations in the ATM gene (Ataxia-Telangiectasia Mutated), which plays crucial roles in repairing double-strand DNA breaks (DSBs). Heterogeneous immunodeficiency, extreme radiosensitivity,
Externí odkaz:
https://doaj.org/article/24c60023d4d3443da02628173b4f8f53
Autor:
Claudia Gómez-Liñán, Elena Gómez-Díaz, Gloria Ceballos-Pérez, Sandra M Fernández-Moya, Antonio M Estévez
Publikováno v:
Nucleic Acids Research. 50:12251-12265
In-depth analysis of the transcriptomes of several model organisms has revealed that genomes are pervasively transcribed, giving rise to an abundance of non-canonical and mainly antisense RNA polymerase II-derived transcripts that are produced from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42d065c89af396b30e24a632f1f45ed
https://doi.org/10.1093/nar/gkac1123
https://doi.org/10.1093/nar/gkac1123
Autor:
Dana M. Klug, Nelly El-Sakkary, Cristina Bosch-Navarrete, Rosario Diaz-Gonzalez, Gloria Ceballos-Pérez, Guiomar Pérez-Moreno, Jeremiah D. Momper, Carlos Cordon-Obras, Francisco Gamarro, Dolores Gonzalez Pacanowska, Maria Santos Martinez-Martinez, Lori Ferrins, Conor R. Caffrey, Eftychia M. Mavrogiannaki, Katherine C. Forbes, Raquel García-Hernández, Claudia Gómez-Liñán, Miguel Navarro, Andreu Saura, Luis M. Ruiz-Pérez, Pilar Manzano, Ali Syed, Lisseth Silva, Michael P. Pollastri
Publikováno v:
J Med Chem
Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty. Historically, the lack of economic incentive to develop new treatments for these diseases ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9937aba3a31ba3131cffe3becb644f09
https://doi.org/10.1021/acs.jmedchem.1c00674
https://doi.org/10.1021/acs.jmedchem.1c00674
Autor:
Pilar Manzano, Maria Santos Martinez-Martinez, Miguel Navarro, Michael P. Pollastri, Naresh Gunaganti, Gloria Ceballos-Pérez, Kirsten Gillingwater, Domingo I. Rojas-Barros, Rosario Diaz-Gonzalez, Baljinder Singh
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
J Med Chem
instname
J Med Chem
Human African trypanosomiasis (HAT), or sleeping sickness, is caused by the protozoan parasite Trypanosoma brucei and transmitted through the bite of infected tsetse flies. The disease is considered fatal if left untreated. To identify new chemotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8b3af0fa2337d349ba09302701f4b6
https://doi.org/10.1021/acs.jmedchem.0c01017
https://doi.org/10.1021/acs.jmedchem.0c01017
Publikováno v:
Nucleic Acids Research
Post-transcriptional regulation of gene expression is particularly important in trypanosomatid protozoa. RNA-binding proteins (RBPs) regulate mRNA stability and translation, yet information about how RBPs are able to link environmental cues to post-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1359ca34396a13f5b2d9038b9425a178
https://pubmed.ncbi.nlm.nih.gov/33744953
https://pubmed.ncbi.nlm.nih.gov/33744953
Autor:
Miguel Navarro, Quillon J. Simpson, Travis J. DeLano, Maria Santos Martinez-Martinez, Raquel García-Hernández, Rosario Diaz-Gonzalez, Westley Tear, Guiomar Pérez-Moreno, William G. Devine, Lori Ferrins, Dolores González-Pacanowska, Luis M. Ruiz-Pérez, Melanie G. Fritsche, Katherine M. Schneider, Michael P. Pollastri, Francisco Gamarro, John K. Fisher, Cristina Bosch-Navarrete, Pilar Manzano-Chinchon, Vivian Hilborne, Dana M. Klug, Raeann M. Dalton, Gloria Ceballos-Pérez, Eftychia M. Mavrogiannaki, Melissa J. Buskes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
Human African trypanosomiasis is a neglected tropical disease (NTD) that is fatal if left untreated. Although approximately 13 million people live in moderate- to high-risk areas for infection, current treatments are plagued by problems with safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c419df9071d8f28b3bdefbdbcc538de7
http://hdl.handle.net/10261/246477
http://hdl.handle.net/10261/246477
