Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Gloria C. Koo"'
Autor:
Luz P. Blanco, Mimi Y. Kim, Danieli Andrade, Mary K. Crow, Jane E. Salmon, Vikki M. Abrahams, Melissa J. Mulla, S. Ananth Karumanchi, Patricia Redecha, Angela M. Alvarez, Kyriakos A. Kirou, Mariana J. Kaplan, Gloria C. Koo
Publikováno v:
Arthritis & Rheumatology. 67:977-987
Systemic lupus erythematosus (SLE), the prototypic systemic autoimmune disease, predominantly afflicts women and presents during reproductive years. Pregnancy in patients with SLE is associated with increased risk for maternal and fetal morbidity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f830c9a34aa1efb1c57f98ecd9862d7e
https://doi.org/10.1002/art.39029
https://doi.org/10.1002/art.39029
Autor:
Gloria C. Koo, Daniela Peruzzi, Luigi Aurisicchio, Nicola La Monica, Gennaro Ciliberto, Wei Zen Wei
Publikováno v:
Human Gene Therapy. 25:121-131
Several cancer vaccine efforts have been directed to simultaneously cotarget multiple tumor antigens, with the intent to achieve broader immune responses and more effective control of cancer growth. Genetic cancer vaccines based on in vivo muscle ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca18639bb2a9961ffec62e02913a48
https://doi.org/10.1089/hum.2013.103
https://doi.org/10.1089/hum.2013.103
Autor:
Gloria C. Koo, Charles M. Rice, Joshua A. Horwitz, Kevin Vega, Bridget M. Donovan, Eva Billerbeck, Rachael N. Labitt, Alexander Ploss, William C. Budell
Publikováno v:
The Journal of Immunology. 191:1753-1764
Humanized mice have emerged as a promising model to study human immunity in vivo. Although they are susceptible to many pathogens exhibiting an almost exclusive human tropism, human immune responses to infection remain functionally impaired. It has r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f2b895bb581b386b91da81d6c99c48
https://doi.org/10.4049/jimmunol.1201518
https://doi.org/10.4049/jimmunol.1201518
Autor:
Gloria C. Koo, Martin S. Springer, Lorraine Malkowitz, Douglas W. Kawka, Kang Cheng, Qi Luo, Serguei Stepaniants, Kenneth K. Wu, Irwin I. Singer, Jeffrey Yuan, Andrew S. Plump, Cheryl B. Le Grand, Jun Zhu, Milana Maletic, Samuel D. Wright, James M. Balkovec, Gloria J.-F. Ding, Sherman T. Waddell, Xia Yang, Rolf Thieringer, Kashmira Shah, Pek Yee Lum, Mingjuan Jane Luo, I-Ming Wang, Anne Hermanowski-Vosatka
Publikováno v:
Physiological Genomics. 45:47-57
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 ameliorated multiple facets of metabolic syndrome and attenuated atheroscleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62219a7783ded2299858a49a0cadc560
https://doi.org/10.1152/physiolgenomics.00109.2012
https://doi.org/10.1152/physiolgenomics.00109.2012
Publikováno v:
European Journal of Immunology. 42:1723-1734
Complement activation modulates DC-mediated T-cell activation, but whether complement affects DC-mediated priming of NK cells is unknown. Here, we demonstrated that conventional DCs (cDCs) from C3−/− and C5aR−/− mice are hyperresponsive to po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79cf02b535e0989be85490dd97b8064e
https://doi.org/10.1002/eji.201142290
https://doi.org/10.1002/eji.201142290
Autor:
Xiaoping Qing, Jane E. Salmon, Milena Vukelic, Gloria C. Koo, Patricia Redecha, Giorgio Perino, Danieli Andrade
Publikováno v:
Arthritis & Rheumatism. 63:2764-2773
Purpose To construct a humanized SLE mouse that resembles the human disease to define pathophysiology and targeted for treatments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9539c50bb4d74c4f089f85fa8dcab42
https://doi.org/10.1002/art.30424
https://doi.org/10.1002/art.30424
Autor:
Gerard R. Kieczykowski, Carrie P. Jones, Ping Liu, Junying Wang, Conrad E. Raab, Qian Si, Xinchun Tong, Thomas J. Lanza, Anne Schuelke, Kelly M. Treonze, Richard A. Mumford, Salony Manior, Stella H. Vincent, James V. Pivnichny, Gloria C. Koo, James P. Jewell, William K. Hagmann, Regina W. Wang, Philip Davies, Linus S. Lin, Malcolm MacCoss
Publikováno v:
Journal of Medicinal Chemistry. 52:3449-3452
Extremely potent very late antigen-4 (VLA-4) antagonists with picomolar, whole blood activity and slow dissociation rates were discovered by incorporating an amino substituent on the proline fragment of the initial lead structure. This level of poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a2b44376091abb5e0b00c51b9e55a39
https://doi.org/10.1021/jm900257b
https://doi.org/10.1021/jm900257b
Publikováno v:
Expert Review of Vaccines
The severe combined immunodeficient (SCID) mouse has no adaptive immunity, lacking mature T and B cells in the peripheral blood or the lymphoid organs. It has been used extensively in biomedical research as a valuable translational model for xeno-eng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7415622e6508d94646aba2edd5c4e2e9
https://doi.org/10.1586/14760584.8.1.113
https://doi.org/10.1586/14760584.8.1.113
Autor:
Danieli, Andrade, Mimi, Kim, Luz P, Blanco, S Ananth, Karumanchi, Gloria C, Koo, Patricia, Redecha, Kyriakos, Kirou, Angela M, Alvarez, Melissa J, Mulla, Mary K, Crow, Vikki M, Abrahams, Mariana J, Kaplan, Jane E, Salmon
Publikováno v:
Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia
Universidad de Antioquia
instacron:Universidad de Antioquia
Objective. To investigate whether an elevatedinterferon-␣(IFN␣) level early in pregnancy is associ-ated with poor pregnancy outcomes and to examine the relationship of an elevated IFN␣level to angiogenicimbalance.Methods. Women were enrolled in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::644e02a3500e0c83d038a713cc877288
Autor:
Kang Cheng, Matthias Strowski, Jianying Xiao, Tsuei-Ju Wu, Ning Ren, Nancy Robertson, Martin S. Springer, Kenneth K. Wu, Zhihua Li, James M. Balkovec, Melba Hernandez, Howard Y. Chen, Cheryl B. Le Grand, Bill Pikounis, Anne Hermanowski-Vosatka, Joseph M. Metzger, Samuel D. Wright, Steven H. Olson, Alison M. Strack, Gloria C. Koo, Steven S. Mundt, Rolf Thieringer, Heather Noonan, Kashmira Shah, James M. Schaeffer, Christian N. Nunes, Bei B. Zhang
Publikováno v:
The Journal of Experimental Medicine
The enzyme 11β–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective glucocorticoid (GC) tone above serum levels. We report that pharmacologic inhibition of 11β-HSD1 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100c617c4f08e8bc6b622a8ee436ebe
http://europepmc.org/articles/PMC2212859
http://europepmc.org/articles/PMC2212859