Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gloria Assaker"'
Autor:
Cedric Darini, Nour Ghaddar, Catherine Chabot, Gloria Assaker, Siham Sabri, Shuo Wang, Jothilatha Krishnamoorthy, Marguerite Buchanan, Adriana Aguilar-Mahecha, Bassam Abdulkarim, Jean Deschenes, Jose Torres, Josie Ursini-Siegel, Mark Basik, Antonis E. Koromilas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The HER2 monoclonal antibody, Trastuzumab, is the current standard treatment for HER2+ cancers but resistance to therapy occurs. Here, the authors show that activation of the PKR/eIF2α-P pathway exhibits anti-tumor effects in HER2+ cancer and is req
Externí odkaz:
https://doaj.org/article/7ecf6c59b1264893ab9910b75de10e72
Autor:
Catherine Chabot, Josie Ursini-Siegel, Jose Torres, Nour Ghaddar, Shuo Wang, Siham Sabri, Adriana Aguilar-Mahecha, Bassam Abdulkarim, Jothilatha Krishnamoorthy, Cedric Darini, Mark Basik, Antonis E. Koromilas, Jean Deschenes, Marguerite Buchanan, Gloria Assaker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Trastuzumab is integral to HER2+ cancer treatment, but its therapeutic index is narrowed by the development of resistance. Phosphorylation of the translation initiation factor eIF2α (eIF2α-P) is the nodal point of the integrated stress response, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee397674edf2348666f721804283f4ba
http://link.springer.com/article/10.1038/s41467-019-10138-8
http://link.springer.com/article/10.1038/s41467-019-10138-8
Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis
Autor:
Rui, Zhang, Jiarong, Li, Gloria, Assaker, Anne, Camirand, Siham, Sabri, Andrew C, Karaplis, Richard, Kremer
Publikováno v:
Advances in experimental medicine and biology. 1164
PTHrP was first discovered as the most common mediator of malignancy-associated hypercalcemia. Subsequently, the discovery of its ubiquitous expression in normal tissues unraveled its role as a physiological autocrine/paracrine regulator. The signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3dada72b7b1eb675bb275b317a497e8
https://pubmed.ncbi.nlm.nih.gov/31576548
https://pubmed.ncbi.nlm.nih.gov/31576548
Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis
Autor:
Andrew C. Karaplis, Gloria Assaker, Siham Sabri, Rui Zhang, Jiarong Li, Richard Kremer, Anne Camirand
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030222536
PTHrP was first discovered as the most common mediator of malignancy-associated hypercalcemia. Subsequently, the discovery of its ubiquitous expression in normal tissues unraveled its role as a physiological autocrine/paracrine regulator. The signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::071a50bcdb51ed83de81f05550a69cb3
https://doi.org/10.1007/978-3-030-22254-3_13
https://doi.org/10.1007/978-3-030-22254-3_13
Autor:
Carl Laflamme, Paul S. Maddox, Desmond She, Jonas F. Dorn, Damien Ramel, Gregory Emery, Gloria Assaker
Publikováno v:
The Journal of Cell Biology
Drosophila Evi5 is a Rab-GAP that acts on the membrane-trafficking mediator Rab11 to promote guidance receptor polarization during border cell migration.
Membrane trafficking has well-defined roles during cell migration. However, its regulation
Membrane trafficking has well-defined roles during cell migration. However, its regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198f26574e073fe844c24dc0505bf43a
http://europepmc.org/articles/PMC3392932
http://europepmc.org/articles/PMC3392932
Publikováno v:
Proceedings of the National Academy of Sciences
Border cell migration is a stereotyped migration occurring during the development of the Drosophila egg chamber. During this process, a cluster composed of six to eight follicle cells migrates between nurse cells toward the oocyte. Receptor tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d65069f2810ad56e0e256eccdd5e074
https://doi.org/10.1073/pnas.1010795108
https://doi.org/10.1073/pnas.1010795108
Publikováno v:
Cancer Research. 78:2598-2598
Triple-negative breast cancer (TNBC) represents 10-20% of all BC cases, and is characterized by an aggressive clinical course with high risk of metastasis and lack of targeted therapy. Gene expression profiling revealed the heterogeneity of TNBC enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df832de5bd21d4f6f8193531ed394193
https://doi.org/10.1158/1538-7445.am2018-2598
https://doi.org/10.1158/1538-7445.am2018-2598
Autor:
Gloria Assaker, Bassam Abdulkarim, Atilla Omeroglu, Léon C van Kempen, Richard Kremer, Jean Deschenes, Siham Sabri, Anne Camirand
Publikováno v:
Cancer Research. 78:2632-2632
Triple-negative breast cancer (TNBC) represents 10-20% of all BC cases, and is characterized by aggressive clinical course, frequent relapse, poor patient outcome, and lack of targeted therapy due to the lack of expression of estrogen receptor (ER),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35fe8cf9ac65fd96459dc6971808fadb
https://doi.org/10.1158/1538-7445.am2018-2632
https://doi.org/10.1158/1538-7445.am2018-2632