Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gloria A. Ashamu"'
Autor:
Victoria C. Bailey, Christelle Moreau, Antony Galione, Gloria A. Ashamu, Andreas H. Guse, Barry V. L. Potter
Publikováno v:
Org. Biomol. Chem.. 9:278-290
Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055080f2cad18d07bdff8a34a18812fe
https://doi.org/10.1039/c0ob00396d
https://doi.org/10.1039/c0ob00396d
Autor:
Shigeo Iino, Antony Galione, Yi Cui, Gloria A. Ashamu, Derek A. Terrar, Stevan Rakovic, Barry V. L. Potter
Publikováno v:
Journal of Biological Chemistry. 274:17820-17827
Oscillations of Ca2+ in heart cells are a major underlying cause of important cardiac arrhythmias, and it is known that Ca2+-induced release of Ca2+ from intracellular stores (the sarcoplasmic reticulum) is fundamental to the generation of such oscil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4931933856b61ffaab851254544755c
https://doi.org/10.1074/jbc.274.25.17820
https://doi.org/10.1074/jbc.274.25.17820
Autor:
Hendrik Schulze-Koops, Martin Hohenegger, Barry V. L. Potter, A. L. Skapenko, Ingeborg Berg, Andreas H. Guse, Karin Weber, P. Heyer, C. P. Da Silva, Gloria A. Ashamu, Georg W. Mayr
Publikováno v:
Nature. 398(6722)
Cyclic ADP-ribose (cADPR) is a natural compound that mobilizes calcium ions in several eukaryotic cells1,2,3. Although it can lead to the release of calcium ions in T lymphocytes4,5,6,7, it has not been firmly established as a second messenger in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40cd499c53bc0b064ec333850b4574f
https://pubmed.ncbi.nlm.nih.gov/10078531
https://pubmed.ncbi.nlm.nih.gov/10078531
Publikováno v:
Biochemistry. 36(31)
Cyclic adenosine diphosphate ribose (cADPR) is a naturally occurring and potent Ca2+-mobilizing agent. Structural analogues are currently required as pharmacological tools for the investigation of this topical molecule, but modifications to date have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efde87d5ca9089eddba4560b2c954b23
https://pubmed.ncbi.nlm.nih.gov/9235996
https://pubmed.ncbi.nlm.nih.gov/9235996
Autor:
Georg W. Mayr, Barry V. L. Potter, Karin Weber, Helmuth Hilz, Gloria A. Ashamu, Cristina P. da Silva, Christian Schulze, Andreas H. Guse, Charlotte N. Armah
Publikováno v:
European journal of biochemistry. 245(2)
1-(5-Phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride [2'-phospho-cyclic ADP-ribose, cAdo(2')P(5')PP-Rib] was prepared enzymatically from NADP+ using ADP-ribosyl-cyclase from Aplysia californica. The product was purified by HP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4e3cfb2972f974bbabe07e50768801
https://pubmed.ncbi.nlm.nih.gov/9151972
https://pubmed.ncbi.nlm.nih.gov/9151972
Autor:
Georg W. Mayr, Andreas H. Guse, Karin Weber, Cristina P. da Silva, Barry V. L. Potter, Gloria A. Ashamu
Publikováno v:
The Journal of biological chemistry. 271(39)
cADP-ribose (cADPr) has recently been shown to release Ca2+ from an intracellular store of permeabilized T lymphocyte cell lines (Guse, A. H., da Silva, C. P., Emmrich, F., Ashamu, G. A., Potter, B. V. L., and Mayr, G. W. (1995) J. Immunol. 155, 3353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61193ec0fa243fc6511f9d262525c6f3
https://pubmed.ncbi.nlm.nih.gov/8798627
https://pubmed.ncbi.nlm.nih.gov/8798627
Publikováno v:
Current biology : CB. 6(8)
Background Cyclic ADP-ribose (cADPR) has been shown to act as a potent cytosolic mediator in a variety of tissues, regulating the release of Ca 2 + from intracellular stores by a mechanism that involves ryanodine receptors. There is controversy over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2167344a8a90137c523ab7fdc0d77d9
https://pubmed.ncbi.nlm.nih.gov/8805333
https://pubmed.ncbi.nlm.nih.gov/8805333
Publikováno v:
J. Chem. Soc., Chem. Commun.. :1359-1360
A broad substrate specificity for adenosine 5′-diphosphate ribosyl cyclase is demonstrated by cyclisation of ribose-and purine-modified nicotinamide adenine dinucleotide analogues to mimics of cyclic adenosine 5′-diphosphate ribose, generating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57c0bb48d02ce909f6de5a8138e80081
https://doi.org/10.1039/c39950001359
https://doi.org/10.1039/c39950001359