Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Gloria A Benavides"'
Autor:
Mariame S. Kane, Gloria A. Benavides, Edie Osuma, Michelle S. Johnson, Helen E. Collins, Yecheng He, David Westbrook, Silvio H. Litovsky, Kasturi Mitra, John C. Chatham, Victor Darley-Usmar, Martin E. Young, Jianhua Zhang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Mitochondria morphology and function, and their quality control by mitophagy, are essential for heart function. We investigated whether these are influenced by time of the day (TOD), sex, and fed or fasting status, using transmission electro
Externí odkaz:
https://doaj.org/article/404d2c5db08241938901383fabf3f138
Autor:
Xiaosen Ouyang, Willayat Y. Wani, Gloria A. Benavides, Matthew J. Redmann, Hai Vo, Thomas van Groen, Victor M. Darley-Usmar, Jianhua Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 10, Pp 4172-4184 (2023)
The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is one such lysosomal protease, which when deficient in humans lead to ne
Externí odkaz:
https://doaj.org/article/2ede50a0f6d7409a92eab27f601812d4
Autor:
Chae‐Myeong Ha, Sayan Bakshi, Manoja K. Brahma, Luke A. Potter, Samuel F. Chang, Zhihuan Sun, Gloria A. Benavides, Lihao He, Prachi Umbarkar, Luyun Zou, Samuel Curfman, Sini Sunny, Andrew J. Paterson, Namakkal‐Soorappan Rajasekaran, Jarrod W. Barnes, Jianhua Zhang, Hind Lal, Min Xie, Victor M. Darley‐Usmar, John C. Chatham, Adam R. Wende
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease through numerous mechanisms, including regulation via posttranslational modifications. A specific posttranslational modification, the additi
Externí odkaz:
https://doaj.org/article/be156b0fab8e4ad2aa747f5829ccfd51
Autor:
Xiaosen Ouyang, Sayan Bakshi, Gloria A. Benavides, Zhihuan Sun, Gerardo Hernandez‐Moreno, Helen E. Collins, Mariame S. Kane, Silvio Litovsky, Martin E. Young, John C. Chatham, Victor Darley‐Usmar, Adam R. Wende, Jianhua Zhang
Publikováno v:
Physiological Reports, Vol 11, Iss 9, Pp n/a-n/a (2023)
Abstract Autophagy is important for protein and organelle quality control. Growing evidence demonstrates that autophagy is tightly controlled by transcriptional mechanisms, including repression by zinc finger containing KRAB and SCAN domains 3 (ZKSCA
Externí odkaz:
https://doaj.org/article/43138afb22a2441aa72b96c9dcaa2f7c
Autor:
Van N. Huynh, Gloria A. Benavides, Michelle S. Johnson, Xiaosen Ouyang, Balu K. Chacko, Edie Osuma, Toni Mueller, John Chatham, Victor M. Darley-Usmar, Jianhua Zhang
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract The accumulation of neurotoxic proteins characteristic of age-related neurodegenerative pathologies such as Alzheimer’s and Parkinson’s diseases is associated with the perturbation of metabolism, bioenergetics, and mitochondrial quality
Externí odkaz:
https://doaj.org/article/68b3c3eb510e4385addb8c4b50678f84
Autor:
Mariya Misheva, Konstantinos Kotzamanis, Luke C. Davies, Victoria J. Tyrrell, Patricia R. S. Rodrigues, Gloria A. Benavides, Christine Hinz, Robert C. Murphy, Paul Kennedy, Philip R. Taylor, Marcela Rosas, Simon A. Jones, James E. McLaren, Sumukh Deshpande, Robert Andrews, Nils Helge Schebb, Magdalena A. Czubala, Mark Gurney, Maceler Aldrovandi, Sven W. Meckelmann, Peter Ghazal, Victor Darley-Usmar, Daniel A. White, Valerie B. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Oxylipins are lipid mediators generated during infection for regulating inflammatory responses, but how they are removed is not completely clear. Here the authors show that cellular oxylipin removal is linked to mitochondria β-oxidation by CPT1, a m
Externí odkaz:
https://doaj.org/article/a3d11671abcf4409a6bdffc0da87c0f3
Autor:
Nastaran Daneshgar, Andrew W. Baguley, Peir-In Liang, Fei Wu, Yi Chu, Michael T. Kinter, Gloria A. Benavides, Michelle S. Johnson, Victor Darley-Usmar, Jianhua Zhang, Kung-Sik Chan, Dao-Fu Dai
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Daneshgar et al. investigated the role of mitochondrial dysfunction in ADPKD and mitochondria protective agents as potential therapeutics. The authors reported decreased mitochondrial complex activity and downregulation of mitochondrial and metabolic
Externí odkaz:
https://doaj.org/article/1d0d0cfe52ff48c79a03d8870143777f
Autor:
Catherine J Libby, Sajina Gc, Gloria A. Benavides, Jennifer L. Fisher, Sarah E. Williford, Sixue Zhang, Anh Nhat Tran, Emily R. Gordon, Amber B. Jones, Kaysaw Tuy, William Flavahan, Juan Gordillo, Ashlee Long, Sara J. Cooper, Brittany N. Lasseigne, Corinne E. Augelli-Szafran, Victor Darley-Usmar, Anita B. Hjelmeland
Publikováno v:
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 101-115 (2021)
The multifaceted roles of metabolism in invasion have been investigated across many cancers. The brain tumor glioblastoma (GBM) is a highly invasive and metabolically plastic tumor with an inevitable recurrence. The neuronal glucose transporter 3 (GL
Externí odkaz:
https://doaj.org/article/8ae81f05eb1749278b5439e70c0972a8
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102241- (2022)
Mitochondrial function is required to meet the energetic and metabolic requirements of the brain. Abnormalities in mitochondrial function, due to genetic or developmental factors, mitochondrial toxins, aging or insufficient mitochondrial quality cont
Externí odkaz:
https://doaj.org/article/1bfbdbf6aa6646e4885320eb1f66e440
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Mitochondrial dysfunction and metabolic decline are prevalent features of aging and age-related disorders, including neurodegeneration. Neurodegenerative diseases are associated with a progressive loss of metabolic homeostasis. This pathogenic declin
Externí odkaz:
https://doaj.org/article/8834ddbe1bde4aa1ba363b7e1e96782e