Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Gloria, Rudenko"'
An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
A Variant Surface Glycoprotein (VSG) coat protects bloodstream form T. brucei. Applying super-resolution microscopy Budzak et al. characterize a set of nuclear bodies, which associate with the active expression site in bloodstream form T. brucei and
Externí odkaz:
https://doaj.org/article/512b5528a291459196d3659ae386f264
Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes
Autor:
James Budzak, Gloria Rudenko
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat protects it from immune attack. This dense layer comprised of ∼107 VSG protei
Externí odkaz:
https://doaj.org/article/4e13d112ee54498ab9c90fb7afc10b21
Autor:
Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005432 (2017)
Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes e
Externí odkaz:
https://doaj.org/article/4a35b7495b2f4c1d877fe6f8ca6eb7b2
Autor:
Johannes P Maree, Andrey Tvardovskiy, Tina Ravnsborg, Ole N Jensen, Gloria Rudenko, Hugh-G Patterton
Publikováno v:
Nucleic acids research. 50(17)
Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and display some unusual genomic and epigenetic properties that provide valuable insight into the early processes employed by eukaryotic ancestors to regulate chromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01808439c1307936448b82ba1831b8b3
https://pubmed.ncbi.nlm.nih.gov/36095123
https://pubmed.ncbi.nlm.nih.gov/36095123
Autor:
Jackie L Y Cheung, Nadina V Wand, Cher-Pheng Ooi, Sophie Ridewood, Richard J Wheeler, Gloria Rudenko
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006023 (2016)
The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled
Externí odkaz:
https://doaj.org/article/d015ce04dd0843399a4a402b17640539
Autor:
Cher-Pheng Ooi, Gloria Rudenko
Publikováno v:
eLife, Vol 3 (2014)
The strategy that sleeping sickness parasites use to evade the mammalian immune system may be linked to the metamorphosis that allows them to transfer from mammals into tsetse flies.
Externí odkaz:
https://doaj.org/article/3ab6538e471a457595bd198e4854c9d3
Autor:
Gloria Rudenko, Bill Wickstead, Georgios Sioutas, Sam Alsford, Carys Davies, Falk Butter, Cher-Pheng Ooi, Haneesh Sidhu, Belinda S. Hall
Publikováno v:
Nucleic Acids Research
The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective variant surface glycoprotein (VSG) coat for survival in the mammalian host. A single trypanosome has >2000 VSG genes and pseudogenes of which only one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea38bfe31395cfa44a697be50163eaa
https://pubmed.ncbi.nlm.nih.gov/33660774
https://pubmed.ncbi.nlm.nih.gov/33660774
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003010 (2012)
The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a ti
Externí odkaz:
https://doaj.org/article/bb9d576f87c644829e8be4d4ff36f30a
Autor:
Terry K Smith, Nadina Vasileva, Eva Gluenz, Stephen Terry, Neil Portman, Susanne Kramer, Mark Carrington, Shulamit Michaeli, Keith Gull, Gloria Rudenko
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7532 (2009)
BACKGROUND:The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesi
Externí odkaz:
https://doaj.org/article/cb4fb228a224482e9f46a4c80335979f
Autor:
Christiane Hertz-Fowler, Luisa M Figueiredo, Michael A Quail, Marion Becker, Andrew Jackson, Nathalie Bason, Karen Brooks, Carol Churcher, Samah Fahkro, Ian Goodhead, Paul Heath, Magdalena Kartvelishvili, Karen Mungall, David Harris, Heidi Hauser, Mandy Sanders, David Saunders, Kathy Seeger, Sarah Sharp, Jesse E Taylor, Danielle Walker, Brian White, Rosanna Young, George A M Cross, Gloria Rudenko, J David Barry, Edward J Louis, Matthew Berriman
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3527 (2008)
Subtelomeric regions are often under-represented in genome sequences of eukaryotes. One of the best known examples of the use of telomere proximity for adaptive purposes are the bloodstream expression sites (BESs) of the African trypanosome Trypanoso
Externí odkaz:
https://doaj.org/article/1c78e94d79a84b92a201a3323f15f31e