Výsledky vyhledávání - "Globerson Levin A"

Akademický článek

Nanoscale CAR Organization at the Immune Synapse Correlates with CAR-T Effector Functions

Autor: Julia Sajman, Oren Yakovian, Naamit Unger Deshet, Shaked Almog, Galit Horn, Tova Waks, Anat Globerson Levin, Eilon Sherman

Publikováno v: Cells, Vol 12, Iss 18, p 2261 (2023)

T cells expressing chimeric antigen receptors (CARs) are at the forefront of clinical treatment of cancers. Still, the nanoscale organization of CARs at the interface of CAR-Ts with target cells, which is essential for TCR-mediated T cell activation,

Externí odkaz: https://doaj.org/article/f22b6b80cb944a8d85fae3569995e08d

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Akademický článek

P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas

Autor: Liat Rousso-Noori, Ignacio Mastandrea, Shauli Talmor, Tova Waks, Anat Globerson Levin, Maarja Haugas, Tambet Teesalu, Luis Alvarez-Vallina, Zelig Eshhar, Dinorah Friedmann-Morvinski

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Chimeric antigen receptor (CAR) T cell therapy has been proposed as a promising approach for treating glioblastoma. Here the authors show that p32 is expressed in murine and human glioma and that p32-directed CAR-T cells promote anti-tumor responses

Externí odkaz: https://doaj.org/article/c9d019d611994e5cb582be3f41cb6a8b

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Akademický článek

Comparing Intraperitoneal and Intravenous Personalized ErbB2CAR-T for the Treatment of Epithelial Ovarian Cancer

Autor: Naamit Deshet-Unger, Galit Horn, Moran Rawet-Slobodkin, Tova Waks, Ido Laskov, Nadav Michaan, Yael Raz, Vered Bar, Adi Zundelevich, Sara Aharon, Lubov Turovsky, Giuseppe Mallel, Seth Salpeter, Guy Neev, Kenneth Samuel Hollander, Ben-Zion Katz, Dan Grisaru, Anat Globerson Levin

Publikováno v: Biomedicines, Vol 10, Iss 9, p 2216 (2022)

High-grade serous ovarian carcinoma (HGSOC) is the most common type of epithelial ovarian cancer. The majority of cases are diagnosed at advanced stages, when intraperitoneal (IP) spread has already occurred. Despite significant surgical and chemothe

Externí odkaz: https://doaj.org/article/16dbc1696e5e4daea159f67c152a7d9b

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Akademický článek

Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

Autor: Yamit Shorer Arbel, Ben-Zion Katz, Ronen Gabizon, Amit Shraga, Yotam Bronstein, Talia Kamdjou, Anat Globerson Levin, Chava Perry, Irit Avivi, Nir London, Yair Herishanu

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitination and proteasomal degradation of the target protein. Using our own designed Bruton’s tyrosine kin

Externí odkaz: https://doaj.org/article/650b70fb17db4836a1e4c93f379c112c

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