GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell ActivationSummary

Autor: Haoye Zhang, Pengcheng Zhou, Wu Xing, Limin Chen, Yangmei Zhou, Hui Yang, Kangkang Fu, Zhenguo Liu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 2, Pp 355-372 (2023)

Background: The role of GLIS2 in fibrotic diseases is controversial. GLIS2 deficiency has been reported to contribute to renal fibrosis in mice and has also been reported to prevent high lipid-induced mice hepatic fibrosis. Methods: Hepatic fibrosis

Externí odkaz: https://doaj.org/article/7b9b51b1bd614d299f6822a13d2c4c06

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Autor: Laura Thirouard, Hélène Holota, Mélusine Monrose, Manon Garcia, Angélique de Haze, Christelle Damon‐Soubeyrand, Yoan Renaud, Jean‐Paul Saru, Alessia Perino, Kristina Schoonjans, Claude Beaudoin, David H. Volle

Publikováno v: Advanced Science, Vol 9, Iss 17, Pp n/a-n/a (2022)

Abstract Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well‐documented previously. This study investi

Externí odkaz: https://doaj.org/article/1c16e21b6be44b36869d7bc07bd1b3b5

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Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Autor: Annette Feuchtinger, Gretchen Wolff, Bilgen Ekim Üstünel, Minako Sakurai, Anne Loft, Felix B. Pedersen, Kan Kau Chow, Peter P. Nawroth, Maria Troullinaki, Mauricio Berriel Diaz, Søren Fisker Schmidt, Mike Krogh Terkelsen, Stephan Herzig, Michele Puglia, Ana Jimena Alfaro, Riccardo Berutti, Blagoy Blagoev, Kim Ravnskjaer, Adriano Maida

Publikováno v: Loft, A, Alfaro, A J, Schmidt, S F, Pedersen, F B, Terkelsen, M K, Puglia, M, Chow, K K, Feuchtinger, A, Troullinaki, M, Maida, A, Wolff, G, Sakurai, M, Berutti, R, Üstünel, B E, Nawroth, P, Ravnskjaer, K, Diaz, M B, Blagoev, B & Herzig, S 2021, ' Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication ', Cell Metabolism, vol. 33, no. 8, pp. 1685-1700.e9 . https://doi.org/10.1016/j.cmet.2021.06.005
Cell Metab. 33, 1685-1700.e9 (2021)

Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-associated fatty liver disease; yet, the mechanisms underlying the progression from the comparatively benign fatty liver state to advanced non-alcoholic steatoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7183305586faeb771006a5f0b783ca33
https://portal.findresearcher.sdu.dk/da/publications/059a9be0-74d1-4a91-9d8c-e040db75bd2a

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