Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery.

Autor: Clementson S; Molecular Discovery and Innovation, H. Lundbeck A/S, Ottiliavej 9, Valby 2500, Denmark.; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark., Matheu SA; Molecular Discovery and Innovation, H. Lundbeck A/S, Ottiliavej 9, Valby 2500, Denmark.; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark., Rørsted EM; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark., Pedersen H; Molecular Discovery and Innovation, H. Lundbeck A/S, Ottiliavej 9, Valby 2500, Denmark., Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark., Clausen RP; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark., Vital P; Molecular Discovery and Innovation, H. Lundbeck A/S, Ottiliavej 9, Valby 2500, Denmark., Glibstrup E; Molecular Discovery and Innovation, H. Lundbeck A/S, Ottiliavej 9, Valby 2500, Denmark., Jessing M; Molecular Discovery and Innovation, H. Lundbeck A/S, Ottiliavej 9, Valby 2500, Denmark., Kristensen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2021 Jun 18; Vol. 86 (12), pp. 8248-8262. Date of Electronic Publication: 2021 Jun 01.

Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis.

Autor: Welin ER; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Ngamnithiporn A; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Klatte M; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Lapointe G; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Pototschnig GM; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., McDermott MSJ; Division of Hematology/Oncology, Department of Medicine, Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Conklin D; Division of Hematology/Oncology, Department of Medicine, Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Gilmore CD; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Tadross PM; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Haley CK; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Negoro K; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Glibstrup E; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Grünanger CU; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Allan KM; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Virgil SC; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Slamon DJ; Division of Hematology/Oncology, Department of Medicine, Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dslamon@mednet.ucla.edu stoltz@caltech.edu., Stoltz BM; Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. dslamon@mednet.ucla.edu stoltz@caltech.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2019 Jan 18; Vol. 363 (6424), pp. 270-275. Date of Electronic Publication: 2018 Dec 20.

A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE.

Autor: Jepsen TH; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Glibstrup E; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Crestey F; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark., Kristensen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

Publikováno v: Beilstein journal of organic chemistry [Beilstein J Org Chem] 2017 May 22; Vol. 13, pp. 988-994. Date of Electronic Publication: 2017 May 22 (Print Publication: 2017).

A comprehensive study of extended tetrathiafulvalene cruciform molecules for molecular electronics: synthesis and electrical transport measurements.

Autor: Parker CR; Department of Chemistry & Center for Exploitation of Solar Energy & Nano-Science Center & Danish-Chinese Center for Nano-Electronics, University of Copenhagen , Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark., Leary E, Frisenda R, Wei Z, Jennum KS, Glibstrup E, Abrahamsen PB, Santella M, Christensen MA, Della Pia EA, Li T, Gonzalez MT, Jiang X, Morsing TJ, Rubio-Bollinger G, Laursen BW, Nørgaard K, van der Zant H, Agrait N, Nielsen MB

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2014 Nov 26; Vol. 136 (47), pp. 16497-507. Date of Electronic Publication: 2014 Nov 17.

Syntheses of propargyl glycosides of disaccharides of the capsular polysaccharides from serotypes 4, 7F, and 9V Streptococcus pneumoniae for glycoconjugate vaccines.

Autor: Taylor, Seth A.¹ (AUTHOR), White, Kendell¹ (AUTHOR), Patton, Regan¹ (AUTHOR), Linder, Anna¹ (AUTHOR), Shin, Spencer¹ (AUTHOR), Nelson, Sophie¹ (AUTHOR), Haymore, Jared¹ (AUTHOR), Zambrano, Joseph¹ (AUTHOR), Hayden, Marcus¹ (AUTHOR), Gubler, Shawn¹ (AUTHOR), Meng, Tianyao¹ (AUTHOR), Finn, M.G.² (AUTHOR), Teyton, Luc³ (AUTHOR), Deng, Shenglou¹ (AUTHOR), Savage, Paul B.¹ (AUTHOR) pbs@byu.edu

Publikováno v: Journal of Carbohydrate Chemistry. 2023, Vol. 42 Issue 7-9, p268-293. 26p.