Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma.

Autor: Tarantino G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ricker CA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang A; Harvard Medical School, Boston, MA, USA., Ge W; Harvard Medical School, Boston, MA, USA., Aprati TJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huang AY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA., Madha S; Worcester Polytechnic Institute, Worcester, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., Chen J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shi Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Glettig M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Feng CH; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Frederick DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Freeman S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Holovatska MM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA., Manos MP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA., Zimmer L; Department of Dermatology, University HospitalEssen, Essen, Germany., Rösch A; Department of Dermatology, University HospitalEssen, Essen, Germany., Zaremba A; Department of Dermatology, University HospitalEssen, Essen, Germany., Livingstone E; Department of Dermatology, University HospitalEssen, Essen, Germany., Jameson JC; Interfaculty Initiative in Health Policy, Harvard University, Cambridge, MA, USA., Saghafian S; Harvard Kennedy School, Harvard University, Cambridge, MA, USA., Lee A; Department of Surgery and Cancer Immunogenomics Research Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zhao K; Department of Surgery and Cancer Immunogenomics Research Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Morris LGT; Department of Surgery and Cancer Immunogenomics Research Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reardon B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Park J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Elmarakeby HA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Al-Azhar University, Cairo, Egypt., Schilling B; Department of Dermatology, University HospitalEssen, Essen, Germany.; Department of Dermatology, University Hospital Würzburg, Würzburg, Germany., Giobbie-Hurder A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA., Vokes NI; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Buchbinder EI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA., Flaherty KT; Massachusetts General Hospital, Boston, MA, USA., Haq R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Boland GM; Massachusetts General Hospital, Boston, MA, USA., Hodi FS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schadendorf D; Department of Dermatology, University HospitalEssen, Essen, Germany., Liu D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Publikováno v: Science advances [Sci Adv] 2024 Nov 29; Vol. 10 (48), pp. eadp4670. Date of Electronic Publication: 2024 Nov 27.