Výsledky vyhledávání - "Glennon V. Bythrow"

Akademický článek

Mycobacterium abscessus Mutants with a Compromised Functional Link between the Type VII ESX-3 System and an Iron Uptake Mechanism Reliant on an Unusual Mycobactin Siderophore

Autor: Glennon V. Bythrow, Manal F. Farhat, Keith Levendosky, Poornima Mohandas, Gabrielle A. Germain, Barney Yoo, Luis E. N. Quadri

Publikováno v: Pathogens, Vol 11, Iss 9, p 953 (2022)

The opportunistic pathogen Mycobacterium abscessus subsp. abscessus (Mab) has become an emerging public health threat due to the increasing number of Mab-associated chronic pulmonary disease cases. Treatment requires multiple drug courses and is ofte

Externí odkaz: https://doaj.org/article/373ae87221484d4dadeeab45da660391

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Mycobacteria Encode Active and Inactive Classes of TesB Fatty-Acyl CoA Thioesterases Revealed through Structural and Functional Analysis

Autor: Luis E. N. Quadri, Jade K. Forwood, Glennon V. Bythrow, Crystall M.D. Swarbrick, David Aragão, Gabrielle Germain

Publikováno v: Biochemistry. 56:1460-1472

Mycobacteria contain a large number of highly divergent species and exhibit unusual lipid metabolism profiles, believed to play important roles in immune invasion. Thioesterases modulate lipid metabolism through the hydrolysis of activated fatty-acyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e4fccc30d365b153446671826904b9
https://doi.org/10.1021/acs.biochem.6b01049

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Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes

Autor: Poornima Mohandas, Luis E. N. Quadri, Glennon V. Bythrow, Tony D. Davis, Maria I. Chiriac, Derek S. Tan

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:5340-5345

Biosynthesis of bacterial natural-product virulence factors is emerging as a promising antibiotic target. Many such natural products are produced by nonribosomal peptide synthetases (NRPS) from amino acid precursors. To develop selective inhibitors o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748567e979637c29ec019641e99e4b02
https://doi.org/10.1016/j.bmcl.2016.09.027

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Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents

Autor: Tezcan Guney, Glennon V. Bythrow, Derek S. Tan, Xuequan Lu, Cheng Ji, Gabrielle Germain, Poornima Mohandas, Sivagami Sundaram Chavadi, Keith Levendosky, Luis E. N. Quadri, Lisa C. Standke

There is a paramount need for expanding the drug armamentarium to counter the growing problem of drug-resistant tuberculosis. Salicyl-AMS, an inhibitor of salicylic acid adenylation enzymes, is a first-in-class antibacterial lead compound for the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0bc6c210596eacc10c585d9ff01018
https://europepmc.org/articles/PMC6530907/

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Pleiotropic consequences of gene knockouts in the phthiocerol dimycocerosate and phenolic glycolipid biosynthetic gene cluster of the opportunistic human pathogen Mycobacterium marinum

Autor: Glennon V. Bythrow, William C. Budell, Emily Mueller, Luis E. N. Quadri, Poornima Mohandas, Andrew S. Au

Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) contribute to the pathogenicity of several mycobacteria. Biosynthesis of these virulence factors requires polyketide synthases and other enzymes that represent potential targets for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19ece702b38651a78e1924130168991
https://europepmc.org/articles/PMC4809995/

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