Proteomic analysis of proteins regulated by TRPS1 transcription factor in DU145 prostate cancer cells

Autor: Robin Wait, Charlotte L. Bevan, Glenn T.G. Chang, Simon C. Gamble, Mila Jhamai, Albert O. Brinkmann

Publikováno v: Biochimica et Biophysica Acta-Proteins and Proteomics, 1774(5), 575-582. Elsevier

The aim of the present study was to identify proteins differentially regulated by TRPS1 in human prostate cancer cells in order to better understand the role of TRPS1 in prostate cancer development. The proteomes of androgen-independent DU145 prostat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586a4c7e0b73df7ddf28bb4934bcae43
https://doi.org/10.1016/j.bbapap.2007.03.011

Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer

Autor: Glenn T.G. Chang, Kimmo Savinainen, Teuvo L.J. Tammela, Tapio Visakorpi, Albert O. Brinkmann, Outi R. Saramäki, Marika J. Linja

Publikováno v: British Journal of Cancer, 90, 1041-1046. Nature Publishing Group
British Journal of Cancer

The long arm of chromosome 8 is one of the most common regions of amplification in cancers of several organs, especially carcinomas of the breast and prostate. TRPS1, MYC and EIF3S3 genes are located in one of the minimal regions of amplification, 8q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab794a2b997fd9193759cd34149ebb87
https://hdl.handle.net/1765/64352

The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor

Autor: Tarik Möröy, Bernhard Horsthemke, Frank J. Kaiser, Hermann-Josef Lüdecke, Glenn T.G. Chang

Publikováno v: Journal of Biological Chemistry, 278(40), 38780-38785. American Society for Biochemistry and Molecular Biology Inc.

The TRPS1 gene encodes a repressor of GATA-mediated transcription. Mutations in this gene cause the tricho-rhino-phalangeal syndromes, but the affected pathways are unknown. In a yeast two-hybrid screen with the C-terminal part of the murine Trps1 pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9d1b6b468753a0a3fbe375ec9e7145
https://doi.org/10.1074/jbc.M306259200

Regulation of expression of Na+, K+-ATPase in androgen-dependent and androgen-independent prostate cancer

Autor: G.J. van Steenbrugge, Leen J. Blok, Glenn T.G. Chang, J.J.H.H.M. De Pont, W.M. Van Weerden, Albert O. Brinkmann, Herman G.P. Swarts, M Steenbeek-Slotboom

Publikováno v: British Journal of Cancer, 81, pp. 28-36
British Journal of Cancer, 81, 28-36
British Journal of Cancer
British Journal of Cancer, 81(1), 28-36. Nature Publishing Group

The β1-subunit of Na+,K+-ATPase was isolated and identified as an androgen down-regulated gene. Expression was observed at high levels in androgen-independent as compared to androgen-dependent (responsive) human prostate cancer cell lines and xenogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efda099e37c06e1432b81f718762715a
https://doi.org/10.1038/sj.bjc.6690647

Vitamin D and Vitamin D Analogs in Cancer Treatment

Autor: G. J. C. M. van den Bemd, Glenn T.G. Chang

Publikováno v: Current Drug Targets, 3, 85-94. Bentham Science Publishers B.V.

The secosteroid hormone 1,25-dihydroxyvitamin D 3 (1,25-(OH) 2D 3) is a key player in the regulation of bone mineralization and calcium homeostasis. In addition, 1,25-(OH) 2D 3 has antiproliferative and prodifferentiation effects on various cells in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f917968938b180f055a86795e92b8b0b
https://doi.org/10.2174/1389450023348064