Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Glenn S. Gerhard"'
Autor:
Thomas G. Martin, Hana Pak, Glenn S. Gerhard, Salim Merali, Carmen Merali, Bonnie Lemster, Praveen Dubey, Charles F. McTiernan, Michael R. Bristow, Arthur M. Feldman, Jonathan A. Kirk
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)
Background Mutations to the co‐chaperone protein BAG3 (B‐cell lymphoma‐2–associated athanogene‐3) are a leading cause of dilated cardiomyopathy (DCM). These mutations often impact the C‐terminal BAG domain (residues 420–499), which regu
Externí odkaz:
https://doaj.org/article/e00324252d774fae9058422acc540cab
Autor:
Scott Kaniper, Dorret Lynch, Samuel M. Owens, Larisa Ibric, Yuliya Vabishchevich, Nana Nyantakyi, Fan Chun, Lionel Sam, Carly Fabrizio, Eman Hamad, Glenn S. Gerhard
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 3, p 271 (2024)
Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive systemic disease involving the extracellular deposition of misfolded transthyretin protein. The hereditary subtype is caused by mutations in the transthyretin (TTR) gene. An estimated 2
Externí odkaz:
https://doaj.org/article/bcca3d1a41684897b278d12ddbd4a8ab
Autor:
Johanna K. DiStefano, Glenn S. Gerhard
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Nonalcoholic fatty liver disease (NAFLD) can develop in lean individuals. Despite a better metabolic profile, the risk of disease progression to hepatic inflammation, fibrosis, and decompensated cirrhosis in the lean is similar to that in ob
Externí odkaz:
https://doaj.org/article/298405b90c774194b9b852cd429490bb
Autor:
Mingyang Xin, Qian Guo, Qingchun Lu, Juan Lu, Po-shun Wang, Yun Dong, Tao Li, Ye Chen, Glenn S. Gerhard, Xiao-feng Yang, Michael Autieri, Ling Yang
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background The majority of mammalian genome is composed of non-coding regions, where numerous long non-coding RNAs (lncRNAs) are transcribed. Although lncRNAs have been identified to regulate fundamental biological processes, most of their f
Externí odkaz:
https://doaj.org/article/2e9a33bcfd9745d1ab243f1d92f568ef
Autor:
Hayley D. Ackerman, Glenn S. Gerhard
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 174 (2023)
Increasing evidence supports a neuroprotective role for bile acids in major neurodegenerative disorders. We studied major human bile acids as signaling molecules for their two cellular receptors, farnesoid X receptor (FXR or NR1H4) and G protein-coup
Externí odkaz:
https://doaj.org/article/7455e5911bf940ff9cb43b9efec416d7
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 5, Pp 1068-1082 (2020)
Externí odkaz:
https://doaj.org/article/03e489489d08404db67578150fca325a
Autor:
Ignazio S. Piras, Anish Raju, Janith Don, Nicholas J. Schork, Glenn S. Gerhard, Johanna K. DiStefano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9296 (2022)
Choline deficiency causes hepatic fat accumulation, and is associated with a higher risk of nonalcoholic fatty liver disease (NAFLD) and more advanced NAFLD-related hepatic fibrosis. Reduced expression of hepatic phosphatidylethanolamine N-methyltran
Externí odkaz:
https://doaj.org/article/d85c7c231f2f4d0ebe0cc2426a226020
Autor:
Glenn S. Gerhard, Bethany Davis, Xiumei Wu, Amanda Hanson, Danielle Wilhelmsen, Ignazio S. Piras, Christopher D. Still, Xin Chu, Anthony T. Petrick, Johanna K. DiStefano
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
We previously reported dysregulated expression of liver-derived messenger RNA (mRNA) and long noncoding RNA (lncRNA) in patients with advanced fibrosis resulting from nonalcoholic fatty liver disease (NAFLD). Here we sought to identify changes in mRN
Externí odkaz:
https://doaj.org/article/d90250de239646099a9ee0ad54099ab8
Autor:
Glenn S. Gerhard, Ivana Malenica, Lorida Llaci, Xin Chu, Anthony T. Petrick, Christopher D. Still, Johanna K. DiStefano
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in liver biopsies representing severe
Externí odkaz:
https://doaj.org/article/f830017fc9df469fad54b8c859e09386
Autor:
Xin Chu, Qunyan Jin, Hui Chen, G. Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J. Carey, Christopher D. Still, Johanna K. DiStefano, Glenn S. Gerhard
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in the progressio
Externí odkaz:
https://doaj.org/article/b98c58eb617040dd8084eb2f15be0978