Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Glenn RA"'
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011887 (2023)
The multi-step process of hepatitis C virus (HCV) entry is facilitated by various host factors, including epidermal growth factor receptor (EGFR) and the tight junction proteins claudin-1 (CLDN1) and occludin (OCLN), which are thought to function at
Externí odkaz:
https://doaj.org/article/b2235c81917e4912be99937de06fc0ef
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Replication complexes (RCs), formed by positive-strand (+) RNA viruses through rearrangements of host endomembranes, protect their replicating RNA from host innate immune defenses. We have shown that two evolutionarily conserved defense syst
Externí odkaz:
https://doaj.org/article/e661cc977e9f4bcb8c0f0d2a168811ff
Autor:
Cosimo Cianfarini, Luise Hassler, Jan Wysocki, Abdelsabour Hassan, Vlad Nicolaescu, Derek Elli, Haley Gula, Amany M. Ibrahim, Glenn Randall, Jack Henkin, Daniel Batlle
Publikováno v:
Cells, Vol 13, Iss 3, p 203 (2024)
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE2) as its main receptor for cell entry. We bioengineered a soluble ACE2 protein termed ACE2 618-DDC-ABD that has increased binding to SARS-
Externí odkaz:
https://doaj.org/article/295ec820daf94cfd922ed4a4157279c9
Autor:
Qizhou Lian, Kui Zhang, Zhao Zhang, Fuyu Duan, Liyan Guo, Weiren Luo, Bobo Wing-Yee Mok, Abhimanyu Thakur, Xiaoshan Ke, Pedram Motallebnejad, Vlad Nicolaescu, Jonathan Chen, Chui Yan Ma, Xiaoya Zhou, Shuo Han, Teng Han, Wei Zhang, Adrian Y. Tan, Tuo Zhang, Xing Wang, Dong Xu, Jenny Xiang, Aimin Xu, Can Liao, Fang-Ping Huang, Ya-Wen Chen, Jie Na, Glenn Randall, Hung-fat Tse, Zhiwei Chen, Yin Chen, Huanhuan Joyce Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Model systems to study SARS-CoV-2 infection are required to better understand the immune response. Here the authors use a lung and macrophage co-culture system by differentiation of human pluripotent stem cells to better understand the phenotype and
Externí odkaz:
https://doaj.org/article/9938f59e696a4a09b36d23579730178b
Autor:
Long C. Nguyen, David M. Renner, Diane Silva, Dongbo Yang, Nicholas A. Parenti, Kaeri M. Medina, Vlad Nicolaescu, Haley Gula, Nir Drayman, Andrea Valdespino, Adil Mohamed, Christopher Dann, Kristin Wannemo, Lydia Robinson-Mailman, Alan Gonzalez, Letícia Stock, Mengrui Cao, Zeyu Qiao, Raymond E. Moellering, Savas Tay, Glenn Randall, Michael F. Beers, Marsha Rich Rosner, Scott A. Oakes, Susan R. Weiss
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed over 6 million individuals worldwide and continues to spread in countries where vaccines are not yet widely available or its citizens are hesitant to become vaccinated.
Externí odkaz:
https://doaj.org/article/5cf75b97da964ea0a46a9ad54694937e
Autor:
Lisa R. Volpatti, Rachel P. Wallace, Shijie Cao, Michal M. Raczy, Ruyi Wang, Laura T. Gray, Aaron T. Alpar, Priscilla S. Briquez, Nikolaos Mitrousis, Tiffany M. Marchell, Maria Stella Sasso, Mindy Nguyen, Aslan Mansurov, Erica Budina, Ani Solanki, Elyse A. Watkins, Mathew R. Schnorenberg, Andrew C. Tremain, Joseph W. Reda, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Shann S. Yu, Balaji Manicassamy, James L. LaBelle, Matthew V. Tirrell, Glenn Randall, Marcin Kwissa, Melody A. Swartz, Jeffrey A. Hubbell
Publikováno v:
ACS Central Science, Vol 7, Iss 8, Pp 1368-1380 (2021)
Externí odkaz:
https://doaj.org/article/7d6f01c438c547eb843b88a5c03b6825
Autor:
Jerzy Osipiuk, Saara-Anne Azizi, Steve Dvorkin, Michael Endres, Robert Jedrzejczak, Krysten A. Jones, Soowon Kang, Rahul S. Kathayat, Youngchang Kim, Vladislav G. Lisnyak, Samantha L. Maki, Vlad Nicolaescu, Cooper A. Taylor, Christine Tesar, Yu-An Zhang, Zhiyao Zhou, Glenn Randall, Karolina Michalska, Scott A. Snyder, Bryan C. Dickinson, Andrzej Joachimiak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The SARS-CoV-2 papain-like protease (PLpro) is of interest as an antiviral drug target. Here, the authors synthesize and characterise naphthalene-based inhibitors for PLpro and present the crystal structures of PLpro in its apo state and with the bou
Externí odkaz:
https://doaj.org/article/78bca1985cf441b2b78df027d7429e6e
Autor:
Youngchang Kim, Jacek Wower, Natalia Maltseva, Changsoo Chang, Robert Jedrzejczak, Mateusz Wilamowski, Soowon Kang, Vlad Nicolaescu, Glenn Randall, Karolina Michalska, Andrzej Joachimiak
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Youngchang Kim, Jacek Wower, and colleagues explore the sequence specificity, metal ion dependence and catalytic mechanism of the Nsp15 endoribonuclease NendoU from SARS-CoV-2. The authors also solve five new crystal structures of the enzyme in compl
Externí odkaz:
https://doaj.org/article/c2e1555f80bc4eb28bc2085247f56486
Autor:
Xiaolei Cai, Min Chen, Aleksander Prominski, Yiliang Lin, Nicholas Ankenbruck, Jillian Rosenberg, Mindy Nguyen, Jiuyun Shi, Anastasia Tomatsidou, Glenn Randall, Dominique Missiakas, John Fung, Eugene B. Chang, Pablo Penaloza‐MacMaster, Bozhi Tian, Jun Huang
Publikováno v:
Advanced Science, Vol 9, Iss 2, Pp n/a-n/a (2022)
Abstract The outbreak of 2019 coronavirus disease (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has resulted in a global pandemic. Despite intensive research, the current treatment options show limited cura
Externí odkaz:
https://doaj.org/article/5a87e165b630476b9dfcd6664dc1a5eb
Autor:
Cathelijne Heymans, Ilse H. de Lange, Matthias C. Hütten, Kaatje Lenaerts, Nadine J. E. de Ruijter, Lilian C. G. A. Kessels, Glenn Rademakers, Veerle Melotte, Werend Boesmans, Masatoshi Saito, Haruo Usuda, Sarah J. Stock, Owen B. Spiller, Michael L. Beeton, Matthew S. Payne, Boris W. Kramer, John P. Newnham, Alan H. Jobe, Matthew W. Kemp, Wim G. van Gemert, Tim G. A. M. Wolfs
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/50255ce9c3d24dfaa4d9ee666201cfd7