Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Glenn R Masson"'
Autor:
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Publikováno v:
eLife, Vol 10 (2021)
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find t
Externí odkaz:
https://doaj.org/article/f3e3156092d447fd9fa28ea08dad4816
Autor:
Graham Neill, Glenn R. Masson
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 compl
Externí odkaz:
https://doaj.org/article/de980eb8aa9c4a768b9b61e5b67c2325
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2
https://doi.org/10.1038/s41586-023-05972-2
Autor:
Lyssa T. Gold, Susan E. Bray, Neil M. Kernohan, Nina Henderson, Maisie Nowicki, Glenn R. Masson
BackgroundMalignant mesothelioma is a tumour that is strongly associated with a history of asbestos exposure and which derives from mesothelial cells that line the serous cavities of the body. The tumour most commonly arises in the pleural cavity, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d6770720c69190ea5bf3938355d153
https://doi.org/10.1101/2023.03.24.23287516
https://doi.org/10.1101/2023.03.24.23287516
Autor:
Pawan Kishor Singh, Ilaria Volpi, Shalini Agarwal, Léa P. Wilhelm, Giada Becchi, Thomas Macartney, Rachel Toth, Adrien Rousseau, Glenn R. Masson, Ian G. Ganley, Miratul M. K. Muqit
Loss of function mutations of the PINK1 kinase cause familial early-onset Parkinson’s disease. PINK1 is activated upon mitochondrial damage to phosphorylate Ubiquitin and Parkin to trigger removal of damaged mitochondria by autophagy (mitophagy). P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::015634019fa7f6fa102df5340138bb7b
https://doi.org/10.1101/2023.03.20.533516
https://doi.org/10.1101/2023.03.20.533516
Autor:
Vanesa Vinciauskaite, Glenn R. Masson
Publikováno v:
Essays in biochemistry.
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming part of the standard repertoire of techniques used by molecular biologists to investigate protein structure and dynamics. This is partly due to the increased use of automation in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8f9f34d55ecd0e23a739ba6c56f615
https://pubmed.ncbi.nlm.nih.gov/36251047
https://pubmed.ncbi.nlm.nih.gov/36251047
Autor:
Madhanagopal Anandapadamanaban, Andreas Boland, Alex Berndt, Olga Perisic, Xiaodan Ni, Stefan M.V. Freund, Jane L. Wagstaff, Roger L. Williams, Sarah L. Maslen, Stephen H. McLaughlin, Keitaro Yamashita, Conny Wing-Heng Yu, Mark Skehel, Maren Heimhalt, Garib N. Murshudov, Glenn R. Masson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63a7d4c77d781be24fc078b87ff7f22
https://doi.org/10.7554/elife.68799.sa2
https://doi.org/10.7554/elife.68799.sa2
Autor:
Glenn R. Masson
Publikováno v:
Biochemical Society Transactions
Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated Stress Response (ISR), a short-lived pathway that allows cells to either regain cellular h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3106ac488c67cb8d85cd3c2fda421052
https://doi.org/10.1042/bst20190331
https://doi.org/10.1042/bst20190331
Autor:
Alex Berndt, Madhanagopal Anandapadamanaban, Keitaro Yamashita, Sarah L. Maslen, Mark Skehel, Glenn R. Masson, Stefan M.V. Freund, Maren Heimhalt, Garib N. Murshudov, Roger L. Williams, Olga Perisic, Conny Wing-Heng Yu, Xiaodan Ni, Jane L. Wagstaff, Stephen H. McLaughlin, Andreas Boland
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
mTORC1 is a kinase complex regulating cell growth, proliferation and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb36120c04dfaa3fc5886b70680a712c
https://doi.org/10.1101/2021.04.28.441853
https://doi.org/10.1101/2021.04.28.441853
Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling
Publikováno v:
Biophysical Journal. 113:2396-2405
Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate specific isoforms of phosphatidylinositol-3-kinase (PI3K). These PI3K li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80a2adf9a3e8ebad62efd119b9f6d5b
https://doi.org/10.1016/j.bpj.2017.09.018
https://doi.org/10.1016/j.bpj.2017.09.018