High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81

Autor: Jing Yang, Glenn R. Gourley, Adam Gilbertsen, Chi Chen, Lei Wang, Karen Smith, Marion Namenwirth, Libang Yang

Publikováno v: Cells, Vol 13, Iss 3, p 236 (2024)

Hyperglycemia, lipotoxicity, and insulin resistance are known to increase the secretion of extracellular matrix from cardiac fibroblasts as well as the activation of paracrine signaling from cardiomyocytes, immune cells, and vascular cells, which rel

Externí odkaz: https://doaj.org/article/81b9250985654c228d6e1e6220fcafad

Contributors

Autor: H. Hesham A-Kader, Sophia Abdulhai, Kareem Abu-Elmagd, Maisam Abu-El-Haija, Douglas G. Adler, Lindsey Albenberg, Estella M. Alonso, Ruchi Amin, Orhan Atay, Renata Auricchio, Robert D. Baker, Susan S. Baker, Katherine Baldwin, Jessica Barry, Todd H. Baron, Bradley Barth, Dorsey M. Bass, Lee M. Bass, Jaime Belkind-Gerson, Marc A. Benninga, Natalie Bhesania, Andrea Bischoff, Samuel Bitton, Samra S. Blanchard, Athos Bousvaros, Brendan Boyle, Jennifer Brewer, Jefferson N. Brownell, Steven W. Bruch, Brendan T. Campbell, Jacob Campbell, Michael Gerard Caty, Carolina S. Cerezo, Ryaz Chagpar, Beth Chatfield, Rebecca N. Cherry, Gail Cohen, Mitchell B. Cohen, Arnold G. Coran, Guilherme Costa, Gail A.M. Cresci, Eileen Crowley, Michael Cruise, Steven J. Czinn, Zev Davidovics, Luis De La Torre, Anthony L. DeRoss, David Devadason, Rajitha Devadoss Venkatesh, Carlo Di Lorenzo, Jennifer L. Dotson, Tracy R. Ediger, Bijan Eghtesad, John F. Eisses, Mounif El Yousif, Karan McBride Emerick, Steven H. Erdman, Rima Fawaz, Ariel E. Feldstein, Melissa Fernandes, Laura S. Finn, Kristin Nicole Fiorino, Douglas S. Fishman, Joel A. Friedlander, Masato Fujiki, John Fung, Ivan Fuss, David Galloway, Donald E. George, Fayez K. Ghishan, Raffaelle Girlanda, Donna Gitt, Deborah A. Goldman, Sue Goodine, Glenn R. Gourley, Nicole Green, Gabrielle Grisotti, Sandeep K. Gupta, Nedim Hadzic, Sanjiv Harpavat, Koji Hashimoto, Maheen Hassan, James E. Heubi, Sohail Z. Husain, Séamus Hussey, Jeffrey S. Hyams, Warren Hyer, Paul E. Hyman, Sabine Iben, Veronica E. Issac, Maureen M. Jonas, Marsha Kay, Mohit Kehar, Deidre Kelly, Karlo Kovacic, Shaun Michael Kunisaki, Jacob A. Kurowski, Jacob C. Langer, Frances C. Lee, Rose Lee, Neal S. LeLeiko, Chris A. Liacouras, Henry Lin, Quin Y. Liu, Kathleen M. Loomes, Peter L. Lu, Sarah Shrager Lusman, Cara Mack, Anshu Maheshwari, Petar Mamula, Michael A. Manfredi, James F. Markowitz, Jonathan E. Markowitz, Maria R. Mascarenhas, Ryann Mayer, Patrick McKiernan, Adam G. Mezoff, Ethan A. Mezoff, Giorgina Mieli-Vergani, Franziska Mohr, Jasmeet Mokha, Hayat Mousa, Lindsay Moye, Simon Murch, Karen F. Murray, Robert Naples, Jaimie D. Nathan, Vicky Lee Ng, Vi Nguyen, Samuel Nurko, Jodie Oauhed, Tina Ogholikhan, Keith T. Oldham, Mohammed Osman, Nadia Ovchinsky, Jennifer Panganiban, Alberto Pena, Robert E. Petras, Marian D. Pfefferkorn, David Piccoli, Travis Piester, Beth Pinkos, Thomas Plesec, Stephanie Polites, Todd Ponsky, Christine Rader, Kadakkal Radhakrishnan, Yannis Reissis, Leonel Rodriguez, Ricardo J. Rodriguez, Isabel Rojas, Ellen S. Rome, Joel R. Rosh, Rachel M. Ruiz, Benjamin Sahn, Atif Saleem, Kate A. Samela, Neha R. Santucci, Miguel Saps, Eleanor H. Sato, Thomas T. Sato, Erica C. Savage, Federico G. Seifarth, Praveen Kumar Conjeevaram Selvakumar, Jason Shapiro, Allan E. Siperstein, Joseph Skelton, Scott Snapper, Oliver S. Soldes, Manu R. Sood, Marisa Gallant Stahl, Shikha S. Sundaram, Francisco A. Sylvester, Jonathan E. Teitelbaum, Natalie A. Terry, Peter Townsend, Riccardo Troncone, Kate Vance, Yvan Vandenplas, Robert S. Venick, David S. Vitale, Jerry Vockley, Eugene Vortia, Mana H. Vriesman, Ghassan T. Wahbeh, R. Matthew Walsh, Suz Warner, Robert Wyllie, Jessica L. Yasuda, Donna Zeiter, Hengqi (Betty) Zheng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a49f5f45a123030a7836b31a5bf5d62b
https://doi.org/10.1016/b978-0-323-67293-1.01002-1

Relationship Between the Efficacy of Cardiac Cell Therapy and the Inhibition of Differentiation of Human iPSC-Derived Nonmyocyte Cardiac Cells Into Myofibroblast-Like Cells

Autor: Zhaohui Geng, Glenn R. Gourley, Ling Gao, Yuhua Wei, Lu Wang, Jianyi Zhang, Libang Yang

Publikováno v: Circulation Research. 123:1313-1325

Rationale: Myofibroblasts are believed to evolve from precursor cells; however, whether noncardiomyocyte cardiac cells (NMCCs; ie, endothelial cells, smooth muscle cells, pericytes, and fibroblasts) that have been derived from human-induced pluripote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7351b4a77cc6752cfb566849376cc181
https://doi.org/10.1161/circresaha.118.313094

Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells

Autor: Adam J Gilbertsen, Caitlin Johnson, Bernice Young, Libang Yang, Jingyi Zhou, Jing Yang, Jianyi Zhang, Ling Gao, Craig A. Henke, Glenn R. Gourley, Zhaohui Geng, Thomas Nickel

Publikováno v: Circulation research. 121(11)

Rationale: The phenotypes of vascular smooth muscle cells (vSMCs) comprise a continuum bounded by predominantly contractile and synthetic cells. Some evidence suggests that contractile vSMCs can assume a more synthetic phenotype in response to ischem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410b6a8bf366183fd88878a39d8259e1
https://pubmed.ncbi.nlm.nih.gov/29021296

Cholestasis in Preterm Infants

Autor: Katie Satrom, Glenn R. Gourley

Publikováno v: Clinics in perinatology. 43(2)

Cholestasis in preterm infants has a multifactorial etiology. Risk factors include degree of prematurity, lack of enteral feeding, intestinal injury, prolonged use of parenteral nutrition (PN), and sepsis. Soy-based parenteral lipid emulsions have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea028afd549ea1e2f1bc81063b3e09e7
https://pubmed.ncbi.nlm.nih.gov/27235213