Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Glenn J, Myatt"'
Autor:
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M. Bradley, Frank Bringezu, William J. Brock, Leigh Ann Burns-Naas, Jon Chambers, Kevin Cross, Michael Dorato, Rosalie Elespuru, Douglas Fuhrer, Frances Hall, Jim Hartke, Gloria D. Jahnke, Felix M. Kluxen, Eric McDuffie, Friedemann Schmidt, Jean-Pierre Valentin, David Woolley, Doris Zane, Glenn J. Myatt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the pres
Externí odkaz:
https://doaj.org/article/3419c3b90a414f7aafa8e7a2a11aedc0
Autor:
Glenn J, Myatt, Arianna, Bassan, Dave, Bower, Candice, Johnson, Scott, Miller, Manuela, Pavan, Kevin P, Cross
Publikováno v:
Comput Toxicol
Mechanistically-driven alternative approaches to hazard assessment invariably require a battery of tests, including both in silico models and experimental data. The decision-making process, from selection of the methods to combining the information b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54b9706ef8d043746a7a841c16f1a627
https://pubmed.ncbi.nlm.nih.gov/35036665
https://pubmed.ncbi.nlm.nih.gov/35036665
Autor:
Candice, Johnson, Lennart T, Anger, Romualdo, Benigni, David, Bower, Frank, Bringezu, Kevin M, Crofton, Mark T D, Cronin, Kevin P, Cross, Magdalena, Dettwiler, Markus, Frericks, Fjodor, Melnikov, Scott, Miller, David W, Roberts, Diana, Suarez-Rodriguez, Alessandra, Roncaglioni, Elena, Lo Piparo, Raymond R, Tice, Craig, Zwickl, Glenn J, Myatt
Publikováno v:
Comput Toxicol
Understanding the reliability and relevance of a toxicological assessment is important for gauging the overall confidence and communicating the degree of uncertainty related to it. The process involved in assessing reliability and relevance is well d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c0d7cdba4ae97555f59d6dc5262e2a5
https://pubmed.ncbi.nlm.nih.gov/35368849
https://pubmed.ncbi.nlm.nih.gov/35368849
Autor:
Kevin P. Cross, Glenn J. Myatt
Publikováno v:
Machine Learning and Deep Learning in Computational Toxicology ISBN: 9783031207297
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f98358c0a8af0fa86d6df4bf9cf0ea7
https://doi.org/10.1007/978-3-031-20730-3_16
https://doi.org/10.1007/978-3-031-20730-3_16
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2425
In silico toxicology protocols help ensure the results from computational toxicology models are performed and documented in a standardized, consistent, transparent, and accepted manner. In silico toxicology protocols for skin sensitization and geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00bdaff2f3081cf8ebc5675c9f8e5c01
https://pubmed.ncbi.nlm.nih.gov/35188641
https://pubmed.ncbi.nlm.nih.gov/35188641
Autor:
Frank Bringezu, Phillip Bellion, Alexander Amberg, Jeffrey M. Birmingham, Alejandra Trejo-Martin, Glenn J. Myatt, Amy L. Mihalchik-Burhans, Amarjit Luniwal, Naomi L. Kruhlak, Rosalie K. Elespuru, Karen H. Watanabe-Sailor, Louise Neilson, Lidia Ceriani, Markus Frericks, Alessandro Brigo, John P. Rooney, Arun R. Pandiri, Helga Gerets, Alice Luu, Arianna Bassan, Angela White, Marc A. Beal, Federica Madia, Manuela Pavan, David Faulkner, Lennart T. Anger, Elena Lo Piparo, Marie C. Fortin, Jordi Mestres, Ian Crooks, David Woolley, Raymond R. Tice, Paul Fowler, Balasubramanian Manickam, David R. Jones, Cynthia V. Rider, Serena Manganelli, Juan Lopez-Belmonte, Gloria D. Jahnke, Kevin P. Cross, Romualdo Benigni
Publikováno v:
Comput Toxicol
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which require enormous resources in both money and time. In silico models have been developed for predicting rodent carcinogens but have not yet found general reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de085dd3094d276c69682e6dfe5bb402
https://europepmc.org/articles/PMC8967183/
https://europepmc.org/articles/PMC8967183/
Autor:
Jean-Pierre Valentin, Daniel P. Russo, David T. Szabo, Lidiya Stavitskaya, Patricia Ruiz, Craig Zwickl, Louise Neilson, Vinicius M. Alves, Candice Johnson, Andreas Bender, Arianna Bassan, Lennart T. Anger, Reena Sandhu, David Woolley, Lisa Beilke, Manuela Pavan, Raymond Kemper, Mark T. D. Cronin, Moiz Mumtaz, Glenn J. Myatt, Alexander Amberg, Yogesh Sabnis, Jui-Hua Hsieh, Markus Schaefer, Amy Pointon, Autumn Bernal, Julia Pletz
Publikováno v:
Comput Toxicol
The kidneys, heart and lungs are vital organ systems evaluated as part of acute or chronic toxicity assessments. New methodologies are being developed to predict these adverse effects based on in vitro and in silico approaches. This paper reviews the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e41082bb951a3c41285999b6f292588
https://europepmc.org/articles/PMC9205464/
https://europepmc.org/articles/PMC9205464/
Autor:
John Nicolette, Donald P. Quigley, Alejandra Trejo-Martin, David Woolley, Lidiya Stavitskaya, Lennart T. Anger, Dave Bower, Jennifer C. Sasaki, Candice Y. Johnson, Michelle O. Kenyon, Glenn J. Myatt, Sandy Weiner, Naomi L. Kruhlak, Susanne Glowienke, Véronique Gervais, Lisa Beilke, Angela White, Penny Leavitt, Roxanne Andaya, James Harvey, Joel P. Bercu, Andrew Teasdale, Jacky Van Gompel, Raymond Kemper, Kevin P. Cross, Scott Miller, Catrin Hasselgren, Barber Christopher Gordon, M. Vijayaraj Reddy, Joerg Wichard, Robert A. Jolly, Alessandro Brigo, Dennie S. Welch, Alexander Amberg, Russell Naven, Masamitsu Honma, Alexis Parenty, Stephen Gomez, Zoryanna Cammerer, Mark Powley, Laura Custer, Krista L. Dobo, Helga Gerets, Wolfgang Muster
Publikováno v:
Regulatory toxicology and pharmacology : RTP
The International Council for Harmonization (ICH) M7 guideline describes a hazard assessment process for impurities that have the potential to be present in a drug substance or drug product. In the absence of adequate experimental bacterial mutagenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc40f205a6b475a7fdd8889147e338e1
https://doi.org/10.1016/j.yrtph.2018.12.007
https://doi.org/10.1016/j.yrtph.2018.12.007
Publikováno v:
Computational Toxicology. 23:100236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbbdce2d76c7403a6949861227d3376e
https://doi.org/10.1016/j.comtox.2022.100236
https://doi.org/10.1016/j.comtox.2022.100236
Autor:
Joel Bercu, Melisa J. Masuda Herrera, Alejandra Trejo-Martin, Catrin Hasselgren, Jean Lord, Jessica Graham, Matthew Schmitz, Lawrence Milchak, Colin Owens, Surya Hari Lal, Richard Marchese Robinson, Sarah Whalley, Phillip Bellion, Anna Vuorinen, Kamila Gromek, William A. Hawkins, Iris Van de Gevel, Kathleen Vriens, Raymond Kemper, Russell Naven, Pierre Ferrer, Glenn J. Myatt
Publikováno v:
Regulatory Toxicology and Pharmacology. 131:105165
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7726cc1674d774d71e17faad1b039cea
https://doi.org/10.1016/j.yrtph.2022.105165
https://doi.org/10.1016/j.yrtph.2022.105165