Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Glenn I, Fishman"'
Autor:
Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C. Westbury, Kristie D. Cox, Kelsey Tjen, Ruolan Song, Glenn I. Fishman, Takako Makita, Henry M. Sucov
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 4, p 161 (2023)
Adult hearts are characterized by inefficient regeneration after injury, thus, the features that support or prevent cardiomyocyte (CM) proliferation are important to clarify. Diploid CMs are a candidate cell type that may have unique proliferative an
Externí odkaz:
https://doaj.org/article/d8d4c517d1e44ae3b2d7f98118750785
Autor:
Daniel J. Blackwell, Michela Faggioni, Matthew J. Wleklinski, Nieves Gomez-Hurtado, Raghav Venkataraman, Chelsea E. Gibbs, Franz J. Baudenbacher, Shiaoching Gong, Glenn I. Fishman, Patrick M. Boyle, Karl Pfeifer, Bjorn C. Knollmann
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs). What remains u
Externí odkaz:
https://doaj.org/article/2aa7c799ff5c4e1e88cbf5f6f46506a5
Autor:
John, Santucci, David S, Park, Akshay, Shekhar, Xianming, Lin, Lei, Bu, Naoko, Yamaguchi, Shana, Mintz, Ernest Whanwook, Chang, Alireza, Khodadadi-Jamayran, Gabriel, Redel-Traub, Mitchell, Goldfarb, Glenn I, Fishman
Publikováno v:
Circulation. Arrhythmia and electrophysiology. 15(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f45a41308a30dc74a70ffeb52f659964
https://pubmed.ncbi.nlm.nih.gov/35862854
https://pubmed.ncbi.nlm.nih.gov/35862854
Autor:
David Y. Barefield, Sean Yamakawa, Ibrahim Tahtah, Jordan J. Sell, Michael Broman, Brigitte Laforest, Sloane Harris, Alejandro Alvarez-Arce, Kelly N. Araujo, Megan J. Puckelwartz, J. Andrew Wasserstrom, Glenn I. Fishman, Elizabeth M. McNally
Publikováno v:
J Mol Cell Cardiol
A premature truncation of MYBPHL in humans and a loss of Mybphl in mice is associated with dilated cardiomyopathy, atrial and ventricular arrhythmias, and atrial enlargement. MYBPHL encodes myosin binding protein H-like (MyBP-HL). Prior work in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee512467d2f2ff5a236a284459aee07
https://doi.org/10.1016/j.yjmcc.2022.04.012
https://doi.org/10.1016/j.yjmcc.2022.04.012
Autor:
Nalani Sachan, Colin K.L. Phoon, Lior Zilberberg, Matthias C. Kugler, Taylor Ene, Shana B. Mintz, Sae-Il Murtada, Dar Weiss, Glenn I. Fishman, Jay D. Humphrey, Daniel B. Rifkin
Publikováno v:
Matrix Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd1e8466a40c74deca02b8a0d5edf1e
https://doi.org/10.1016/j.matbio.2023.05.004
https://doi.org/10.1016/j.matbio.2023.05.004
Autor:
David S. Park, Akshay Shekhar, Christopher Marra, Xianming Lin, Carolina Vasquez, Sergio Solinas, Kevin Kelley, Gregory Morley, Mitchell Goldfarb, Glenn I. Fishman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Fever is a defence mechanism against infection, but it may also cause abnormal heart rhythm viaunknown mechanism. Here the authors identify FHF2 protein as a key regulator of myocardial excitability that protects the heart against conduction failure
Externí odkaz:
https://doaj.org/article/dbdb59efebce4638830ecefe86c9f954
Publikováno v:
Stem Cell Reports, Vol 4, Iss 6, Pp 1089-1102 (2015)
Dysfunction of the specialized cardiac conduction system (CCS) is associated with life-threatening arrhythmias. Strategies to derive CCS cells, including rare Purkinje cells (PCs), would facilitate models for mechanistic studies and drug discovery an
Externí odkaz:
https://doaj.org/article/dd8b07a04d904638b1e02209f67c7b27
Purkinje cardiomyocytes of the ventricular conduction system are highly diploid but not regenerative
Autor:
Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C. Westbury, Kristie D. Cox, Kelsey Tjen, Ruolan Song, Glenn I. Fishman, Takako Makita, Henry M. Sucov
Inefficiency of regeneration underlies many of the pathologies associated with heart injury and disease. Ventricular diploid cardiomyocytes (CMs) are a candidate population that may have enhanced proliferative and regenerative properties [1-3], but s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::034bc01b1947604d2b73a28556383254
https://doi.org/10.1101/2022.10.29.514354
https://doi.org/10.1101/2022.10.29.514354
Autor:
John Santucci, David S. Park, Akshay Shekhar, Xianming Lin, Lei Bu, Naoko Yamaguchi, Shana Mintz, Ernest Whanwook Chang, Alireza Khodadadi-Jamayran, Gabriel Redel-Traub, Mitchell Goldfarb, Glenn I. Fishman
Publikováno v:
Circulation: Arrhythmia and Electrophysiology. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f881a986e016a90a8bb1aed2327c4063
https://doi.org/10.1161/circep.122.011296
https://doi.org/10.1161/circep.122.011296
Autor:
Glenn I. Fishman, David S. Park, Mitchell Goldfarb, Ying Xie, Yue Liu, Akshay Shekhar, Vasilisa Iatckova, Christopher Marra, Libor Velíšek, Jana Velíšková
Publikováno v:
Epilepsia
Objective Fibroblast growth factor homologous factors (FHFs) are brain and cardiac sodium channel-binding proteins that modulate channel density and inactivation gating. A recurrent de novo gain-of-function missense mutation in the FHF1(FGF12) gene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b39acbb183987ed16ed53f53b8bf7e
https://doi.org/10.1111/epi.16916
https://doi.org/10.1111/epi.16916