Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Glenn Hegamyer"'
Autor:
Nancy H. Colburn, John P. Hagan, Glenn Hegamyer, Alyson R. Baker, Aaron P. Jansen, Tobias Schmid
Supplementary Figures 1-5, Table 1, Text from Translation Inhibitor Pdcd4 Is Targeted for Degradation during Tumor Promotion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9bfeaa6ca85aabbbeeed29724fa8a0
https://doi.org/10.1158/0008-5472.22374888.v1
https://doi.org/10.1158/0008-5472.22374888.v1
Autor:
Nancy H. Colburn, John P. Hagan, Glenn Hegamyer, Alyson R. Baker, Aaron P. Jansen, Tobias Schmid
Inactivation of tumor suppressors is among the rate-limiting steps in carcinogenesis that occur during the tumor promotion stage. The translation inhibitor programmed cell death 4 (Pdcd4) suppresses tumorigenesis and invasion. Although Pdcd4 is not m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bdea4088d02f232247d435f2b216e4b
https://doi.org/10.1158/0008-5472.c.6497628
https://doi.org/10.1158/0008-5472.c.6497628
Publikováno v:
Molecular Carcinogenesis. 3:243-250
The murine gene pro1 has been cloned from JB6 epidermal cell lines that are sensitive to neoplastic transformation by tumor promoters. Insensitive JB6 variants acquire susceptibility to neoplastic transformation by tumor promoters when transfected wi
Publikováno v:
Genomics. 66:204-212
Changes that occur during tumor promotion, the rate-limiting phase of multistep carcinogenesis, may offer the best targets for prevention of cancer or reversal of early disease. The murine epidermal JB6 promotion-sensitive (P+) and -resistant (P-) ce
Autor:
Nancy H. Colburn, Hidetoshi Yoshinaga, Shuning Zhan, Joan L. Cmarik, Sachiko Matsuhashi, Hongzhong Min, Glenn Hegamyer, Molly Kulesz-Martin
Publikováno v:
Proceedings of the National Academy of Sciences. 96:14037-14042
An mRNA differential display comparison of mouse JB6 promotion-sensitive (P+) and -resistant (P−) cells identified a novel gene product that inhibits neoplastic transformation. The JB6 P+ and P− cells are genetic variants that differ in their tra
Autor:
Kavitha Sithanandam, Glenn Hegamyer, Rebecca G. Watts, Hua Li, Hyungtae Kim, Nancy H. Colburn, Yi Sun
Publikováno v:
Journal of Biological Chemistry. 270:19312-19319
Mouse tissue inhibitor of metalloproteinases-3 (mTIMP-3), a gene specifically not expressed in neoplastic JB6 cells, has been isolated recently through the use of the mRNA differential display technique (Sun, Y., Hegamyer, G., and Colburn, N. H.(1994
Publikováno v:
International Journal of Cancer. 55:952-956
Mutational inactivation of p53, a potential tumor-suppressor gene, has been found in many tumors of humans as well as rodents. The p53 status in normal and transformed mouse liver cell lines has, however, not been investigated. We examined possible p
Metastasis to bone, liver and lungs is the primary cause of death in breast cancer patients. Our studies have revealed that the novel tumor suppressor Pdcd4 inhibits breast cancer cell migration and invasion in vitro. Loss of Pdcd4 in human nonmetast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfa07c0d5fd4d5dfccff3b0520c6264
https://europepmc.org/articles/PMC3419530/
https://europepmc.org/articles/PMC3419530/
Autor:
I.-H. Chen, Glenn Hegamyer, Yu-Juen Cheng, Nancy H. Colburn, Jen-Yang Chen, Ya Cao, Kai-Tai Yao, Yi Sun, Allan Hildesheim
Publikováno v:
Proceedings of the National Academy of Sciences. 89:6516-6520
Point mutations in the p53 gene have been detected in a variety of human cancers; the mutations are clustered in four "hot-spots" located in the coding region of exons 5, 7, and 8, which coincide with the four most highly conserved regions of the gen
Autor:
Glenn Hegamyer, Dolores Winterstein, Sylvie Poirier, Yi Sun, Nancy H. Colburn, John L. Seed, Sacha Malin, Ya Cao
Publikováno v:
Molecular Carcinogenesis. 4:297-307
A transforming activity associated with Chinese nasopharyngeal carcinoma (NPC) cell line CNE2 DNA has been identified by transfer into nontransformed promotion-sensitive mouse JB6(P+) C141 cells. To clone this transformation-associated sequence, we c