Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Glenn Hauk"'
Autor:
Glenn Hauk, Gregory D Bowman
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131690 (2015)
The DEAD-box RNA helicase Ded1, which is essential in yeast and known as DDX3 in humans, shuttles between the nucleus and cytoplasm and takes part in several basic processes including RNA processing and translation. A key interacting partner of Ded1
Externí odkaz:
https://doaj.org/article/078b13ed35e24bafa6520197a58c69e3
Autor:
Yu Imai, Glenn Hauk, Jeffrey Quigley, Libang Liang, Sangkeun Son, Meghan Ghiglieri, Michael F. Gates, Madeleine Morrissette, Negar Shahsavari, Samantha Niles, Donna Baldisseri, Chandrashekhar Honrao, Xiaoyu Ma, Jason J. Guo, James M. Berger, Kim Lewis
Publikováno v:
Nat Chem Biol
The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of conventional broad-spectrum compounds selects for resistance in off-target pathogens and harms the microbiome. This is especially true for Mycobacterium tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b3963934c81503b0a8f49459d249f4
https://doi.org/10.1038/s41589-022-01102-7
https://doi.org/10.1038/s41589-022-01102-7
Autor:
Vagolu Siva Krishna, Samar H. Abbas, Hossameldin A. Aziz, Gamal El Din A. Abuo-Rahma, James M. Berger, Glenn Hauk, Dharmarajan Sriram, Gamal A. I. Moustafa
Publikováno v:
Medicinal Chemistry Research. 28:1272-1283
New nitric oxide (NO) donating fluoroquinolones/nitrate ester hybrids were prepared and their structures were characterized by various spectroscopic and analytical tools. The release of NO from the prepared nitrate esters was measured using the modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bebcb64328b2331036277254e6fe6e18
https://doi.org/10.1007/s00044-019-02372-y
https://doi.org/10.1007/s00044-019-02372-y
Autor:
Hossameldin A. Aziz, Safwat M. Rabea, Vagolu Siva Krishna, Samar H. Abbas, Glenn Hauk, Gamal A. I. Moustafa, James M. Berger, Gamal El Din A. Abuo-Rahma, Dharmarajan Sriram
A new series of nitric oxide-donating fluoroquinolone/oximes was prepared in this study. The nitric oxide release from the prepared compounds was measured using a modified Griess colorimetric method. The antitubercular evaluation of the synthesized c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993e5c4527d014821318cb932184f130
https://eprints.soton.ac.uk/444043/
https://eprints.soton.ac.uk/444043/
Autor:
Samar H. Abbas, Glenn Hauk, Rehab Mahmoud Abd El-Baky, Gamal A. I. Moustafa, Hamada H.H. Mohammed, Gamal El Din A. Abuo-Rahma, Satoshi Mitarai, James M. Berger, El-Shimaa M.N. Abdelhafez, Masayoshi Arai
Publikováno v:
Bioorganic Chemistry. 88:102952
New N-4-piperazinyl ciprofloxacin-triazole hybrids 6a-o were prepared and characterized. The in vitro antimycobacterial activity revealed that compound 6a experienced promising antimycobacterial activity against Mycobactrium smegmatis compared with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ded39445e0b9f049fb89c651d22ce8
https://doi.org/10.1016/j.bioorg.2019.102952
https://doi.org/10.1016/j.bioorg.2019.102952
Autor:
James M. Berger, Glenn Hauk
All cells must copy and express genes in accord with internal and external cues. The proper timing and response of such events relies on the active control of higher-order genomic organization. Cells use ATP-dependent molecular machines to alter the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f3f75fb94364e6f01d32f466762141
https://europepmc.org/articles/PMC4785063/
https://europepmc.org/articles/PMC4785063/
Autor:
Gregory D. Bowman, Glenn Hauk
Publikováno v:
Current Opinion in Structural Biology. 21:719-727
This review focuses on recent structural insights into regulation and nucleic acid binding of Superfamily 2 (SF2)-type helicases as they relate to chromatin remodelers. We review structural features of the Chd1 chromatin remodeler regarding regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a07527569fc586976d81e602efd381
https://doi.org/10.1016/j.sbi.2011.09.003
https://doi.org/10.1016/j.sbi.2011.09.003
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83bba4c46fd7feb74111b591bffb14ff
https://doi.org/10.1096/fasebj.25.1_supplement.lb40
https://doi.org/10.1096/fasebj.25.1_supplement.lb40
Chromatin remodelers are ATP-driven machines that assemble, slide, and remove nucleosomes from DNA, but how the ATPase motors of remodelers are regulated is poorly understood. Here we show that the double chromodomain unit of the Chd1 remodeler block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466b6c14c80a5ee0063d7bae61199518
https://europepmc.org/articles/PMC2950701/
https://europepmc.org/articles/PMC2950701/
Autor:
Philip A. Beachy, Glenn Hauk, Jason S. McLellan, Rodolfo Ghirlando, Daniel J. Leahy, Xiaoyan Zheng
Publikováno v:
Nature
Hedgehog (Hh) proteins specify tissue pattern in metazoan embryos by forming gradients that emanate from discrete sites of expression and elicit concentration-dependent cellular differentiation or proliferation responses. Cellular responses to Hh and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53894ea306b7ca0089546971c589be4e
https://pubmed.ncbi.nlm.nih.gov/18794898
https://pubmed.ncbi.nlm.nih.gov/18794898